Identification of amino acid residues in GluR1 responsible for ligand binding and desensitization

Journal of Neuroscience

Volumn 21, Issue 9, 2001, Pages 3052-3062

  Banke, T G ^b   Greenwood, J R ^a   Christensen, J K ^a   Liljefors, T ^a   Traynelis, S F ^b   Schousboe, A ^a   Pickering, Darryl S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPA receptor; Binding site; Desensitization; GluR1; GluR2; GluR3; GluR4 agonist subtype selectivity; Mutant receptors

Indexed keywords

AMPA RECEPTOR; BROMOHOMOIBOTENIC ACID; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; LIGAND; PHENYLALANINE; RECEPTOR SUBTYPE; TYROSINE; UNCLASSIFIED DRUG; WATER;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

EID: 0035341409     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-09-03052.2001     Document Type: Article

References (39)

1. Agonist-induced isomerization in a glutamate receptor ligand-binding domain
2. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core
3. Structure of a glutamate-receptor ligand-binding core in complex with kainate
4. o AMPA receptors
5. Glutamate in neurologic diseases
6. Differential assembly of coexpressed glutamate receptor subunits in neurons of rat cerebral cortex
7. Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid
8. Agonist discrimination between AMPA receptor subtypes
9. The glutamate receptor ion channels
10. Pentameric subunit stoichiometry of a neuronal glutamate receptor
11. A computational procedure for determining energetically favorable binding sites on biologically important macromolecules
12. Heterocycles as bioisosteres for the ω-carboxylate moiety of glutamate in AMPA receptor agonists: A review and theoretical study
13. Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid
14. Cloned glutamate receptors
15. AMPA receptor-mediated excitotoxicity in neocortical neurons is developmentally regulated and dependent upon receptor desensitization
16. Role of desensitization and subunit expression for kainate receptor-mediated neurotoxicity in murine neocortical cultures
17. Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing
18. New class of glutamate agonist structurally related to ibotenic acid
19. An orphan glutamate channel points the way to the gates
20. Detecting subtle sequence signals: A Gibbs sampling strategy for multiple alignment
21. Functional effects of mutations in the putative agonist binding region of recombinant α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors
22. + channel determined by construction of multimeric cDNAs
23. Control of kinetic properties of AMPA receptor channels by nuclear RNA editing
24. A tetrameric subunit stoichiometry for a glutamate receptor-channel complex
25. A venus flytrap mechanism for activation and desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
26. Influence of cooperativity on hydrogen bond networks
27. The physiology of excitatory amino acids in the vertebrate central nervous system
28. MacroModel: An integrated software system for modeling organic and bioorganic molecules using molecular mechanics
29. A molecular determinant for submillisecond desensitization in glutamate receptors
30. o receptors expressed in Sf9 insect cells
31. The macro- and microarchitectures of the ligand-binding domain of glutamate receptors
32. Cyclothiazide differentially modulates desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants
33. AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate
34. The tetrameric structure of a glutamate receptor channel
35. A workbench for multiple alignment construction and analysis
36. Flip and flop: A cell-specific functional switch in glutamate-operated channels in the CNS
37. Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins
38. A point mutation in the glutamate binding site blocks desensitization of AMPA receptors
39. Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel