Excitatory amino acid receptor ligands: Resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3- hydroxyisoxazol-5-yl)propionic acid

Journal of Medicinal Chemistry

Volumn 41, Issue 6, 1998, Pages 930-939

  Johansen, Tommy N ^a   Ebert, Bjarke ^a   Bräuner Osborne, Hans ^a   Didriksen, Michael ^b   Christensen, Inge T ^a   Søby, Karina K ^b   Madsen, Ulf ^a   Krogsgaard Larsen, Povl ^a   Brehm, Lotte ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (4 BUTYL 3 HYDROXYISOXAZOL 5 YL)PROPIONIC ACID; 2 AMINO 3 (4 BUTYL 3 HYDROXYISOXAZOL 5 YL)PROPIONIC ACID HEMIHYDRATE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; EXCITATORY AMINO ACID RECEPTOR; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; KAINIC ACID RECEPTOR; LIGAND; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; CONVULSION; DRUG EFFECT; DRUG PENETRATION; DRUG POTENCY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ELECTROPHYSIOLOGY; ENANTIOMER; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; X RAY CRYSTALLOGRAPHY;

ALANINE; ANIMALS; ANTICONVULSANTS; BRAIN; CALCIUM CHLORIDE; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; ISOXAZOLES; MALE; MICE; MOLECULAR CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM;

EID: 0032510387     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9706731     Document Type: Article

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