Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors

Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2002, Pages 2101-2111

  Shepherd, Timothy A ^a   Aikins, James A ^a   Bleakman, David ^a   Cantrell, Buddy E ^a   Rearick, John P ^a,c   Simon, Richard L ^a   Smith, Edward C R ^a   Stephenson, Gregory A ^a   Zimmerman, Dennis M ^a   Mandelzys, Allan ^b   Jarvie, Keith R ^b   Ho, Ken ^b   Deverill, Michelle ^b   Kamboj, Rajender K ^b  

^a ELI LILLY AND COMPANY   (United States)

^b NPS Allelix Corp   (Canada)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CYCLOPENTANE DERIVATIVE; LIGAND; SULFONAMIDE;

ALLOSTERISM; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY;

CELL LINE; CYCLOPENTANES; EXCITATORY AMINO ACID AGENTS; GLUTAMIC ACID; HUMANS; RECEPTORS, AMPA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0037046547     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0105474     Document Type: Article

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