Mouse homologue of coq7/clk-1, longevity gene in Caenorhabditis elegans, is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis

Biochemical and Biophysical Research Communications

Volumn 289, Issue 2, 2001, Pages 463-471

  Nakai, Daisuke ^a,b   Yuasa, Shigeki ^c   Takahashi, Mayumi ^a   Shimizu, Takahiko ^a   Asaumi, Sunao ^a   Isono, Kyoichi ^c   Takao, Toshifumi ^d   Suzuki, Yo ichi ^a   Kuroyanagi, Hidehito ^a   Hirokawa, Katsuiku ^b   Koseki, Haruhiko ^c   Shirsawa, Takuji ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Coq7 clk 1; Electron microscopy; Embryogenesis; Knock out mice; Longevity; Mitochondria; Mitochondriopathy; Neurogenesis; Transgene; Ubiquinone

Indexed keywords

COENZYME Q 7; PROTEIN DERIVATIVE; UBIQUINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CELL DIVISION; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME SYNTHESIS; KNOCKOUT MOUSE; LONGEVITY; LYSOSOME; MITOCHONDRION; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE;

BOVINAE; CAENORHABDITIS ELEGANS; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0035976759     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5977     Document Type: Article

References (30)

1. Determination of life-span in Caenorhabditis elegans by four clock genes
2. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
3. Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human
4. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1
5. Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: A gene required for ubiquinone biosynthesis with potential implications for aging
6. The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis
7. Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids
8. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
9. A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants
10. Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans
11. Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans
12. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
13. The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation
14. The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene
15. A vector for expressing foreign genes in the brains and hearts of transgenic mice
16. Mitochondrial ultrastructure in embryos after implantation
17. Ultrastructural study of mitochondria and their cristae in embryonic rats and primate (N. nemistrina)
18. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
19. Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA
20. Mitochondrial neurogastrointestinal encephalomyopathy: Diagnosis by rectal biopsy
21. 10
22. Mitochondrial ubiquinone homologues, superoxide radical generation, and longevity in different mammalian species
23. Ubiquinone biosynthesis by the microsomal fraction from rat liver
24. Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content
25. Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration
26. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
27. Oxidative stress, caloric restriction, and aging
28. 10 and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals
29. Biochemical, physiological and medical aspects of ubiquinone function
30. 6 and iron reduction are responsible for the extracellular ascorbate stabilization at the plasma membrane of Saccharomyces cerevisiae