Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells

Cancer Research

Volumn 61, Issue 7, 2001, Pages 2945-2952

  Munster P N ^a   Srethapakdi, M ^a   Moasser, M M ^a   Rosen, N ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; ANSAMYCIN DERIVATIVE; HEAT SHOCK PROTEIN 90; MILK FAT; MILK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CELL CYCLE G1 PHASE; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; HUMAN; HUMAN CELL; LIPID COMPOSITION; PRIORITY JOURNAL; PROTEIN INDUCTION; TUMOR DIFFERENTIATION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BENZOQUINONES; BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL DIVISION; G1 PHASE; GLYCOLIPIDS; GLYCOPROTEINS; HSP90 HEAT-SHOCK PROTEINS; LACTAMS, MACROCYCLIC; MILK PROTEINS; PHENOTYPE; PHOSPHORYLATION; QUINONES; RETINOBLASTOMA PROTEIN; RIFABUTIN; TUMOR CELLS, CULTURED;

EID: 0035300564     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
2. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
3. Heat-induced chaperone activity of HsP90
4. Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90
5. The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase
6. Geldanamycth-induced destabilization of Raf-1 involves the proteasome
7. The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network
8. Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells
9. Polyubiquitination and proteasomal degradation of the p 185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin
10. erbB-2 oncogene inhibition by geldanamycin derivatives: Synthesis, mechanism of action, and structure-activity relationships
11. The function of steroid hormone receptors is inhibited by the hsp90-specific compound geldanamycin
12. The hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors
13. Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases
14. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo
15. Perturbation of hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome
16. Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins
17. Effects of the tyrosine-kinase inhibitor geldanamycin on ligand-induced Her-2/neu activation, receptor expression and proliferation of Her-2-positive malignant cell lines
18. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
19. 1 arrest
20. Flow cytometric analysis of G1- and G2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements
21. Nile Red: A selective fluorescent stain for intracellular lipid droplets
22. A program for automated hematoxylin and eosin staining
23. Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases
24. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
25. Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA)
26. Differentiation of cultured human breast cancer cells (AU-565 and MCF-7) associated with loss of cell surface HER-2/neu antigen
27. An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4
28. Induction of erythroid differentiation of K562 human leukemic cells by herbimycin A. an inhibitor of tyrosine kinase activity
29. Herbimycin A down-regulates messages of cyclin D1 and c-myc during erythroid differentiation of K562 cells
30. Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line
31. Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway
32. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones
33. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties
34. Hsp90 as a capacitor for morphological evolution
35. Expression and roles of heat shock proteins in human breast cancer