The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

Journal of Biological Chemistry

Volumn 272, Issue 7, 1997, Pages 4013-4020

  Stancato, Louis F ^a   Silverstein, Adam M ^a   Owens Grillo, Janet K ^a   Chow, Yu Hua ^b   Jove, Richard ^b   Pratt, William B ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANSAMYCIN DERIVATIVE; BENZOQUINONE; EPIDERMAL GROWTH FACTOR; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN ANTIBODY; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; BACULOVIRUS; CELL LINE; COMPLEX FORMATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; FIBROBLAST; HELA CELL; HUMAN; HUMAN CELL; IMMUNOADSORPTION; INSECT; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; CELL LINE; EPIDERMAL GROWTH FACTOR; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; QUINONES; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SPODOPTERA;

EID: 0031054517     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.7.4013     Document Type: Article

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