Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf- 1-MEK-mitogen-activated protein kinase signalling pathway

Molecular and Cellular Biology

Volumn 16, Issue 10, 1996, Pages 5839-5845

  Schulte, Theodor W ^a,c   Blagosklonny, Mikhail V ^a   Romanova, Larissa ^a   Mushinski, J Frederic ^a   Monia, Brett P ^b   Johnston, Joseph F ^b   Nguyen, Phuongmai ^a   Trepel, Jane ^a   Neckers, Leonard M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c Clinical Pharmacology Branch   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME SUBSTRATE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0029813620     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5839     Document Type: Article

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