Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

Oncogene

Volumn 14, Issue 23, 1997, Pages 2809-2816

  Whitesell, Luke ^a,d   Sutphin, Patrick ^a   An, Wen G ^b   Schulte, Theodor ^b   Blagosklonny, Mikhail V ^b,c   Neckers, Len ^b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NONE   (United States)

Author keywords

Benzoquinone ansamycins; Lactacystin; Proteasome; Ubiquitin

Indexed keywords

ANSAMYCIN DERIVATIVE; BENZOQUINONE; ENZYME INHIBITOR; GELDANAMYCIN; MUTANT PROTEIN; PROTEASOME; PROTEIN P53;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN STABILITY; RAT; TUMOR CELL; TUMOR SUPPRESSOR GENE;

ACETYLCYSTEINE; ANIMALS; BENZOQUINONES; CYCLOHEXIMIDE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DETERGENTS; ENZYME INHIBITORS; HALF-LIFE; HUMANS; LACTAMS, MACROCYCLIC; LEUPEPTINS; MICE; MULTIENZYME COMPLEXES; MUTATION; POLYETHYLENE GLYCOLS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SYNTHESIS INHIBITORS; QUINONES; RATS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

ANIMALIA;

EID: 0030878952     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1201120     Document Type: Article

References (36)

1. Blagosklonny MV, Toretsky J, Bohen S and Neckers L. (1996). Proc. Natl. Acad. Sci. USA, 93, 8379-8383.
2. Blagosklonny MV, Toretsky J and Neckers L. (1995). Oncogene, 11, 933-939.
3. Chowdary DR, Dermody JJ, Jha KK and Ozer HL. (1994). Mol. Cell. Biol., 14, 1997-2003.
4. Ciechanover A. (1994). Cell, 79, 13-21.
5. Ciechanover A, DiGiuseppe JA, Bercovich B, Orian A, Richter JD, Schwartz AL and Brodeur GM. (1991). Proc. Natl. Acad. Sci. USA, 88, 139-143.
6. Ciechanover A, Shkedy D, Oren M and Bercovich B. (1994). J. Biol. Chem., 269, 9582-9589.
7. Delmolino L, Band H and Band V. (1993). Carcinogenesis, 14, 827-832.
8. Eytan E, Armon T, Heller H, Beck S and Hershko A. (1993). J. Biol. Chem., 268, 4668-4674.
9. Fenteany G, Standaert RF, Lane WF, Choi S, Corey EJ and Schreiber SL. (1995). Science, 268, 726-730.
10. Finlay CA, Hinds PW, Tan TH, Eliyahu D, Oren M and Levine AJ. (1988). Mol. Cell. Biol., 8, 531-539.
11. Gannon JV, Greaves R, Iggo R and Lane DP. (1990). EMBO J., 9, 1595-1602.
12. Gropper R, Brandt RA, Elias S, Bearer CF, Mayer A, Schwartz AL and Ciechanover A. (1991). J. Biol. Chem., 266, 3602-3610.
13. Hadari T, Warms JVB. Rose IA and Hershko A. (1992). J. Biol. Chem., 267, 719-727.
14. Hinds P, Finlay C and Levine AJ. (1989). J. Virol., 63, 739-746.
15. Hough R, Pratt G and Rechsteiner M. (1987). J. Biol. Chem., 262, 8303-8313.
16. Jariel-Encontre I, Pariat M, Martin F, Carillo S and Salvat C. (1995). J. Biol. Chem., 270, 11623-11627.
17. Maki CG, Huibregtse JM and Howley PM. (1996). Cancer Res., 56, 2649-2654.
18. Martinez J, Georgoff I, Martinez J and Levine AJ. (1991). Genes Dev., 5, 151-159.
19. Medcalf EA and Millner J. (1993). Oncogene, 8, 2847-2851.
20. Milner J and Medcalf EA. (1991). Cell. 65, 765-774.
21. Milner J, Medcalf EA and Cook AC. (1991). Mol. Cell. Biol., 11, 12-19.
22. Mimnaugh EG, Chavany C and Neckers L. (1996). J. Biol. Chem., 271, 22796-22801.
23. Murakami Y, Matsufuji S, Kameji T, Hayashi S, Igarashi K, Tamura T, Tanaka K and Ichihara A. (1992). Nature, 360, 597-599.
24. Oren M, Maltzman W and Levine AJ. (1981). Mol. Cell. Biol., 1, 101-110.
25. Orlowski M and Michaud C. (1989). Biochemistry, 28, 9270-9278.
26. Reihaus E, Kohler M, Kraiss S, Oren M and Montenarh M. (1990). Oncogene, 5, 137-145.
27. Rivett JA. (1989). Arch. Biochem. Biophys., 268, 1-8.
28. Scheffner M, Huibregtse JM and Howley PM. (1994). Proc. Natl. Acad. Sci. USA, 91, 8797-8801.
29. Scheffner M, Huibregtse JM, Vierstra RD and Howley PM. (1993). Cell, 75, 495-505.
30. Scheffner M, Takahashi T, Huibregtse JM, Minna JD and Howley PM. (1992). J. Virol., 66, 5100-5105.
31. Scheffner M, Werness BA, Huibregtse JM, Levine AJ and Howley PM. (1990). Cell, 63, 1129-1136.
32. Sepp-Lorenzino E, Ma Z, Lebwohl DE, Vinitsky A and Rosen N. (1995). J. Biol. Chem., 270, 16580-16587.
33. Shkedy D, Gonen H, Bercovich B and Ciechanover A. (1994). FEBS Lett, 348, 126-130.
34. Ward CL, Omura S and Kopito RR. (1995). Cell, 83, 121-127.
35. Whitesell L and Cook P. (1996). Mol. Endo., 10, 705-712.
36. Zhang N, Wilkinson K and Bownes M. (1993). Dev. Biol., 157, 214-223.