Negative regulation by dexamethasone of fluvastatin-inducible CYP2B expression in primary cultures of rat hepatocytes: Role of CYP3A

Biochemical Pharmacology

Volumn 55, Issue 9, 1998, Pages 1435-1443

  Kocarek, Thomas A ^a   Reddy, Anita B ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

CYP; Cytochrome P450; Dexamethasone; Fluvastatin; Glucocorticoid; Hepatocyte; Phenobarbital

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; FLUINDOSTATIN; GLUCOCORTICOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; PHENOBARBITAL; TROLEANDOMYCIN;

ADOLESCENT; ANIMAL CELL; ARTICLE; DRUG EFFECT; DRUG METABOLISM; ENZYME INDUCTION; HORMONAL REGULATION; LIVER CELL; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ENZYME INHIBITORS; FATTY ACIDS, MONOUNSATURATED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROXYMETHYLGLUTARYL COA REDUCTASES; INDOLES; KINETICS; LIVER; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STEROID HYDROXYLASES; TRANSCRIPTION, GENETIC;

EID: 0032499424     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00658-8     Document Type: Article

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