Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: Inhibitors of squalene synthase are potent inducers of CYP2b expression in primary cultured rat hepatocytes and rat liver

Molecular Pharmacology

Volumn 54, Issue 3, 1998, Pages 474-484

  Kocarek, Thomas A ^a   Kraniak, Janice M ^a   Reddy, Anita B ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; CYTOCHROME P450; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; PENTOXYRESORUFIN DEALKYLASE; PHENOBARBITAL; SQ 34919; SQUALENE SYNTHASE INHIBITOR; STEROL; UNCLASSIFIED DRUG; ZARAGOZIC ACID A;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME INDUCTION; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; INTRAPERITONEAL DRUG ADMINISTRATION; LIPOGENESIS; LIVER; LIVER CELL; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; STEROL SYNTHESIS;

EID: 0031663606     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.3.474     Document Type: Article

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