UDP-glucuronosyltransferase activity in human liver and colon

Gastroenterology

Volumn 116, Issue 1, 1999, Pages 149-160

  Strassburg, C P ^a   Nguyen, N ^a   Manns, M P ^a   Tukey, R H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 TERT BUTYLPHENOL; BENZO[A]PYRENE DERIVATIVE; DNA; ESTRONE; GLUCURONOSYLTRANSFERASE; LIVER PROTEIN; MESSENGER RNA; NARINGENIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CATALYSIS; CHILD; CONTROLLED STUDY; DRUG GLUCURONIDATION; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; FEMALE; GLUCURONIDATION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LIVER; LIVER MICROSOME; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGMOID; TISSUE SPECIFICITY;

EID: 0032924835     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(99)70239-8     Document Type: Article

References (38)

1. CP Strassburg K Oldhafer MP Manns RH. Tukey Differential expression of the UGT1A locus in human liver, biliary and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue Mol Pharmacol 52 1997 212 220
2. CP Strassburg MP Manns RH. Tukey Expression of the UDP-glucuronosyltransferase 1A locus in human colon: identification and characterization of the novel extrahepatic UGT1A8 J Biol Chem 273 1998 8719 8726
3. PI Mackenzie IS Owens B Burchell KW Bock A Bairoch A Belanger S Fournel-Gigleux M Green DW Hum T Iyanagi D Lancet P Louisot J Magdalou J Roy Chowdhury JK Ritter H Schachter TR Tephly KF Tipton DW. Nebert The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence Pharmacogenetics 7 1997 255 269
4. G Monaghan DJ Clarke S Povey CG See M Boxer B. Burchell Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4Q13 Genomics 23 1994 496 499
5. B Burchell CH Brierley G Monaghan DJ. Clarke The structure and function of the UDP-glucuronosyltransferase gene family Adv Pharmacol 42 1998 335 338
6. JK Ritter F Chen YY Sheen HM Tran S Kimura MT Yeatman IS. Owens A novel complex locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini J Biol Chem 267 1992 3257 3261
7. JK Ritter JM Crawford IS. Owens Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells J Biol Chem 266 1991 1043 1047
8. B Mojarrabi R Butler PI. Mackenzie cDNA cloning and characterization of the human UDP-glucuronosyltransferase, UGT1A3 Biochem Biophys Res Commun 225 1996 785 790
9. D Harding S Fournel-Gigleux MR Jackson B. Burchell Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells Proc Natl Acad Sci USA 85 1988 8381 8385
10. R Wooster L Sutherland T Ebner D Clarke O Da Cruz e Silva B. Burchell Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family Biochem J 278 1991 465 469
11. J Roy Chowdhury A Wolkoff N Roy Chowdhury IM. Arias Hereditary jaundice and disorders of bilirubin metabolism 7th ed CR Scriver AI Beaudet WS Sly D Valle The metabolic and molecular basis of inherited diseases. 1995 : McGraw Hill New York 2161 2208
12. PJ Bosma J Seppen B Goldhoorn C Bakker R Oude Elferink J Roy Chowdhury N Roy Chowdhury PL. Jansen Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidatin isoform in man J Biol Chem 269 1994 17960 17964
13. T Ebner B Burchell Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family Drug Metab Dispos 21 1993 50 54
14. T Ebner RP Remmel B. Burchell Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol Mol Pharmacol 43 1993 649 654
15. CD King MD Green GR Rios BL Coffmann IS Owens WP Bishop Tephly TR The glucuronidation of exogenous and endogneous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1 Arch Biochem Biophys 332 1996 92 100
16. CP Strassburg MP Manns RH. Tukey Differential downregulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer Cancer Res 57 1997 2979 2985
17. WHM Peters L Kock FM Nagengast PG. Kremers Biotransformation enzymes in human intestine: critical low levels in the colon? Gut 32 1991 408 412
18. WH Peters WA Allebes PL Jansen LG Poels PJ. Capel Characterization and tissue specificity of a monoclonal antibody against human uridine diphosphate-glucuronosyltransferase Gastroenterology 93 1987 162 169
19. WM McDonnell E Hitomi FK. Askari Identification of bilirubin UDP-GTs in the human alimentary tract in accordance with the gut as a putative metabolic organ Biochem Pharmacol 51 1996 483 488
20. S Matern H Matern EH Farthmann W. Gerok Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5'-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes J Clin Invest 74 1984 402 410
21. KW. Bock UDP-glucuronosyltransferases and their role in metabolism and disposition of carcinogenesis Adv Pharmacol 27 1994 367 383
22. MM. Bradford A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
23. N Nguyen RH. Tukey Baculovirus-directed expression of rabbit UDP-glucuronosyltransferases in Spodoptera frugiperda cells Drug Metab Dispos 25 1997 745 749
24. CP Strassburg P Obermayer-Straub B Alex M Durazzo M Rizzetto RH Tukey MP. Manns Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis Gastroenterology 111 1996 1576 1586
25. F Chen JK Ritter MG Wang OW McBride RA Lubet IS. Owens Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms Biochemistry 32 1993 10648 10657
26. MD Green EM Oturu TR. Tephly Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates Drug Metab Dispos 22 1994 799 805
27. RH Tukey UR Pendurthi NT Nguyen MD Green TR. Tephly Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13 J Biol Chem 268 1993 15260 15266
28. CP Strassburg B Alex F Zindy G Gerken B Lüttig KH Meyer zum Büschenfelde C Bréchot MP. Manns Identification of cyclin A as a molecular target of antinuclear antibodies (ANA) in hepatic and non-hepatic autoimmune diseases J Hepatol 25 1996 859 866
29. O Crivelli C Lavarini E Chiaberge A Amoroso P Farci F Negro M. Rizzetto Microsomal autoantibodies in chronic infection with the HbsAg-associated delta agent Clin Exp Immunol 54 1983 232 238
30. T Philipp M Durazzo C Trautwein B Alex P Straub JG Lamb EF Johnson RH Tukey MP. Manns Recognition of uridine diphosphate glucuronosyltransferase by LKM-3 antibodies in chronic hepatitis D Lancet 344 1994 578 581
31. GJ. Dutton Glucuronidation of drugs and other compounds 1980 : CRC Boca Raton, FL 3 268
32. KW Bock W Lilienblum G Fischer G Schirmer BS. Bock-Hennig The role of conjugation reactions in detoxification Arch Toxicol 60 1987 22 29
33. RH Tukey RE Billings AP Autor TR. Tephly Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p -nitrophenol UDP-glucuronyltransferase Biochem J 179 1979 59 65
34. Z Zhong FC Kauffman RG. Thurmann Inhibition of glucuronidation of benzo(α)pyrene phenols by long-chain fatty acids Cancer Res 51 1991 4511 4515
35. OMP Singh AB Graham GC. Wood The phospholipid dependence of UDP-glucuronosyltransferase: conformation/reactivity studies with purified enzyme Biochem Biophys Res Commun 107 1982 345 349
36. A Yamashita T Nagatsuka M Watanabe H Kondo T Sugiura K. Waku Inhibition of UDP-glucuronosyltransferase activity by fatty acyl-CoA. Kinetic studies and structure-function relationship Biochem Pharmacol 53 1997 561 570
37. A Yamashita K Sato M Watanabe Y Tokudome T Sugiura K. Waku Induction of coenzyme A–dependent transacylation activity in rat liver microsomes by administration of clofibrate Biochim Biophys Acta 1211 1994 263 269
38. BE. Corkey Analysis of acyl-coenzyme A esters in biological samples Methods Enzymol 166 1988 55 70