Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: Relationship between UGT1A1 promoter genotype and variability in a liver bank

Pharmacogenetics

Volumn 10, Issue 8, 2000, Pages 727-739

  Fisher, M B ^a   VandenBranden, M ^a   Findlay, K ^a   Burchell, B ^a   Thummel, K E ^a   Hall, S D ^a   Wrighton, S A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

First pass metabolism; Glucuronidation; Interindividual variability; Tissue distribution

Indexed keywords

ESTRADIOL DERIVATIVE; GLUCURONOSYLTRANSFERASE; MORPHINE 3 GLUCURONIDE; PARACETAMOL GLUCURONIDE;

ALLELE; ARTICLE; CONTROLLED STUDY; DRUG GLUCURONIDATION; ENZYME ACTIVITY; FIRST PASS EFFECT; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; LIVER PRESERVATION; MICROSOME; PRIORITY JOURNAL; PROMOTER REGION; TISSUE DISTRIBUTION;

ACETAMINOPHEN; ALAMETHICIN; ALLELES; ESTRADIOL; GENOTYPE; GLUCURONOSYLTRANSFERASE; HOMOZYGOTE; HUMANS; INTESTINES; KIDNEY; KINETICS; LIVER; LUNG; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; MORPHINE; MORPHINE DERIVATIVES; MUTATION; PROMOTER REGIONS (GENETICS); TISSUE BANKS; TISSUE DISTRIBUTION; VARIATION (GENETICS);

EID: 0033661491     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200011000-00007     Document Type: Article

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