Panipenum, a carbapenem antibiotic, increases the level of hepatic UDP-glucuronic acid in rats

Drug Metabolism and Disposition

Volumn 28, Issue 12, 2000, Pages 1484-1486

  Yamamura, Naotoshi ^a   Imura Miyoshi, Kaoru ^a   Naganuma, Hideo ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; GLUCURONOSYLTRANSFERASE; PANIPENEM; URIDINE DIPHOSPHATE GLUCURONIC ACID; VALPROIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG MECHANISM; ENZYME ACTIVITY; LIVER LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARBAPENEMS; LIVER; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; THIENAMYCINS; URIDINE DIPHOSPHATE GLUCURONIC ACID; VALPROIC ACID;

ANIMALIA;

EID: 0033669808     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Hepatobiliary disposition of valproic acid and valproate glucuronide: Use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions
2. Protein measurement with folin phenol reagent
3. CS-976 (panipenem/betamipron), a new carbapenem antibiotic
4. Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipenem/betamipron (Correspondence)
5. Effects of adenosine on glucuronidation and uridine diphosphate glucuronic acid (UDPGA) synthesis in isolated rat hepatocytes
6. Determination of hepatic uridine 5'-diphosphoglucuronic acid concentration by conjugation with diethylstilbestrol
7. Effect of panipenem on the pharmacokinetics of valproic acid in dogs
8. Panipenem, carbapenem antibiotic, enhances the glucuronidation of intravenously administered valproic acid in rats
9. 3H-labeled 1-O-valproyl-β-D-glucopyranuronic acid, the main metabolite of valproic acid in human