Identification of bilirubin UDP-GTs in the human alimentary tract in accordance with the gut as a putative metabolic organ

Biochemical Pharmacology

Volumn 51, Issue 4, 1996, Pages 483-488

  McDonnell, W Michael ^a,b   Hitomi, Eri ^a   Askari, Frederick K ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c 5500 MSRB I ^*  (United States)

Author keywords

conjugation; detoxification; enzyme; glucuronidation; liver; metabolism

Indexed keywords

BILIRUBIN; BILIRUBIN GLUCURONIDE; GLUCURONOSYLTRANSFERASE; ISOENZYME; RNA;

ADULT; ANIMAL CELL; ARTICLE; BILIRUBIN METABOLISM; CHEEK MUCOSA; COLON; CONTROLLED STUDY; DIGESTIVE SYSTEM; DUODENUM; ENDOSCOPIC BIOPSY; ESOPHAGUS; FEMALE; GENETIC TRANSFECTION; GLUCURONIDATION; HUMAN; HUMAN TISSUE; MALE; MOLECULAR GENETICS; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PUNCH BIOPSY; STOMACH ANTRUM; STOMACH FUNDUS; TISSUE DISTRIBUTION; VOLUNTEER;

EID: 0030028130     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02224-4     Document Type: Article

References (20)

1. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT and Owen IS, A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267: 3257-3261, 1992.
2. Askari FK, Hitomi E, Thiney M and Wilson JM, Retroviral mediated expression of HUG Br 1 in Crigler-Najjar syndrome Type I human fibroblasts and correction of the genetic defect in Gunn rat hepatocytes. Gene Therapy 2: 203-208, 1995.
3. Askari F, Chowdhury NR, van Es HHG, Jansen PLM, Lederstein M, Wilson JM and Chowdhury JR, Construction of retroviral vectors for transferring human bilirubin-UDP-glucuronosyltransferase gene: Toward gene therapy for Crigler-Najjar syndrome-I. Hepatology 14: (Abstract 126A), 1991.
4. Medley MM, Hooker RL, Rabinowitz S, Holton R and Jaffe BM, Correction of congenital indirect hyperbilirubinemia by small intestinal transplantation. Am J Surg 169: 20-27, 1995.
5. Peters WHM and Jansen PLM, Immunocharacterization of UDP-glucuronyltransferase isoenzymes in human liver, intestine and kidney. Biochem Pharmacol 37: 564-567, 1988.
6. van Es HHG, Goldhoorn BG, Paul-Abrahamse M, Oude Elferink RPJ and Jansen PLM, Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I. J Clin Invest 85: 1199-1205, 1990.
7. McDonnell WM, Scheiman JM and Traber PG, Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract. Gastroenterology 103: 1509-1516, 1992.
8. Chomczynski P and Sacchi N, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
9. Ritter JK, Crawford JM and Owens IS. Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J Biol Chem 266: 1043-1047, 1991.
10. Lown KS, Kolars JC, Thummel KE, Barnett JL, Kunze KL, Wrighton SA and Watkins PB, Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Drug Metab Dispos 22: 947-955, 1994.
11. Chowdhury JR, Chowdhury NR, Wu G, Shouval R and Arias IM, Bilirubin mono- and diglucuronide formation by human liver in vitro: Assay by high pressure liquid chromatography. Hepatology 1: 622-627, 1981.
12. Blanckaert N, Analysis of bilirubin and bilirubin mono- and di-conjugates. Determination of their relative amounts in biological samples. Biochem J 185: 115-128, 1980.
13. Cuypers HTM, Ter Haar EM and Jansen PLM, Microsomal conjugation and oxidation of bilirubin. Biochim Biophys Acta 758: 135-143, 1983.
14. Higgs JB, Zeldes W, Kozarsky K, Schteingart M, Kan L, Bohlke P, Krieger K, Davis W and Fox DA, A novel pathway of human T lymphocyte activation. Identification by a monoclonal antibody generated against a rheumatoid synovial T cell line. J Immunol 140: 3758-3765, 1988.
15. Traber PG, McDonnell WM, Wang W and Florence R, Expression and regulation of P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tract. Biochim Biophys Acta 1171: 167-175, 1992.
16. Burchell B, Ebner T, Baird S, Senafi SB, Clarke D, Brierley C and Sutherland L, Use of cloned and expressed human liver UDP-glucuronyltransferase for analysis of drug glucuronide formation and assessment of drug toxicity. Environ Health Perspect 102: 19-23, 1994.
17. Aono S, Yamada Y, Keino H, Sasaoka Y, Nakagawa T, Onishi S, Mimura S, Koiwai O and Sato H, A new type of defect in the gene for bilirubin uridine 5′-diphosphate-glucuronosyltransferase in a patient with Crigler-Najjar syndrome type I. Pediatr Res 35: 629-632, 1994.
18. Bosma PJ, Seppen J, Goldhoorn B, Bakker C, Elferink PJO, Chowdhury JR, Chowdhury NR and Jansen PLM, Bilirubin UDP-glucuronyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 269: 17960-17964, 1994.
19. Arias I (Ed.), The Liver Biology and Pathobiology, p. 489. Raven Press, New York, 1994.
20. Watkins PB, Drug metabolism by cytochromes P450 in the liver and small bowel. Gastroenterol Clin North Am Gastrointestinal Pharmacology 21: 511-526, 1992.