Comparative N-glucuronidation kinetics of ketotifen and amitriptyline by expressed human UDP-glucuronosyltransferases and liver microsomes

Drug Metabolism and Disposition

Volumn 28, Issue 8, 2000, Pages 869-872

  Breyer Pfaff, U ^a   Mey, U ^a   Green, M D ^a   Tephly, T R ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; GLUCURONOSYLTRANSFERASE; KETOTIFEN;

ARTICLE; CATALYSIS; CATALYST; DRUG GLUCURONIDATION; ENANTIOMER; HUMAN; LIVER MICROSOME; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; REACTION ANALYSIS; REACTION TIME;

AMITRIPTYLINE; ANTI-ALLERGIC AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CELLS, CULTURED; GLUCURONIC ACID; GLUCURONOSYLTRANSFERASE; HUMANS; KETOTIFEN; KINETICS; MICROSOMES, LIVER; STEREOISOMERISM;

EID: 0033862494     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. The chemical modification of human liver UDP-glucuronosyltransferase UGT1*6 reveals the involvement of a carboxyl group in catalysis
2. Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine
3. Biphasic kinetics of quaternary ammonium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes
4. Substrate specificities of two stably expressed human liver UDP- glucuronosyltransferases of the UGT1 gene family
5. Stable expression of two human UDP-glucuronosyltransferase cDNAs in V79 cell cultures
6. Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides
7. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
8. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein
9. Glucuronidation of amine substrates by purified and expressed UDP- glucuronosyltransferase proteins
10. Radiation inactivation analysis of microsomal UDP- glucuronosyltransferases catalysing mono- and diglucuronide formation of 3,6- dihydroxybenzo(a)pyrene and 3,6-dihydroxychrysene
11. +-Glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group
12. Differential induction of rat liver microsomal UDP- glucuronosyltransferase activities by various inducing agents
13. Protein measurement with the Folin phenol reagent
14. Conjugation of the enantiomers of ketotifen to four isomeric quaternary ammonium glucuronides in humans in vivo and in liver microsomes
15. The molecular weights of UDP-glucuronyltransferase determined with radiation-inactivation analysis. A molecular model of bilirubin UDP- glucuronyltransferase
16. Structural and functional studies of UDP-glucuronosyltransferases