-
2
-
-
0025813375
-
The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
-
2 Sun XJ, Rothenberg PL, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF. The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 1991, 352:73-77.
-
(1991)
Nature
, vol.352
, pp. 73-77
-
-
Sun, X.J.1
Rothenberg, P.L.2
Kahn, C.R.3
Backer, J.M.4
Araki, E.5
Wilden, P.A.6
Cahill, D.A.7
Goldstein, B.J.8
White, M.F.9
-
3
-
-
0029148591
-
Role of IRS-2 in insulin and cytokine signalling
-
3 Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG, Jr., Glasheen EM, Lane WS, Pierce JH, White MF. Role of IRS-2 in insulin and cytokine signalling. Nature 1995, 377:173-177.
-
(1995)
Nature
, vol.377
, pp. 173-177
-
-
Sun, X.J.1
Wang, L.M.2
Zhang, Y.3
Yenush, L.4
Myers M.G., Jr.5
Glasheen, E.M.6
Lane, W.S.7
Pierce, J.H.8
White, M.F.9
-
4
-
-
0030995946
-
The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family
-
4 Lavan BE, Lane WS, Lienhard GE. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J Biol Chem 1997, 272:11439-11443.
-
(1997)
J Biol Chem
, vol.272
, pp. 11439-11443
-
-
Lavan, B.E.1
Lane, W.S.2
Lienhard, G.E.3
-
5
-
-
0030848782
-
A novel 160 kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
-
5 Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE. A novel 160 kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. J Biol Chem 272:21403-21407.
-
J Biol Chem
, vol.272
, pp. 21403-21407
-
-
Lavan, B.E.1
Fantin, V.R.2
Chang, E.T.3
Lane, W.S.4
Keller, S.R.5
Lienhard, G.E.6
-
6
-
-
0032143284
-
Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
-
6 Shepherd PR, Withers DJ, Siddle K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998, 333:471-490.
-
(1998)
Biochem J
, vol.333
, pp. 471-490
-
-
Shepherd, P.R.1
Withers, D.J.2
Siddle, K.3
-
7
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
7 Araki E, Lipes MA, Patti ME, Brüning JC, Haag BL, III, Johnson RS, Kahn CR. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994, 372:186-190.
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Brüning, J.C.4
Haag B.L. III5
Johnson, R.S.6
Kahn, C.R.7
-
8
-
-
0028032894
-
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
-
8 Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 1994, 372:182-186.
-
(1994)
Nature
, vol.372
, pp. 182-186
-
-
Tamemoto, H.1
Kadowaki, T.2
Tobe, K.3
Yagi, T.4
Sakura, H.5
Hayakawa, T.6
Terauchi, Y.7
Ueki, K.8
Kaburagi, Y.9
Satoh, S.10
Sekihara, H.11
Yoshioka, S.12
Horikoshi, H.13
Furuta, Y.14
Ikawa, Y.15
Kasuga, M.16
Yazaki, Y.17
Aizawa, S.18
-
9
-
-
0029897280
-
Insulin signaling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice
-
9 Yamauchi T, Tobe K, Tamemoto H, Ueki K, Kaburagi Y, Yamamoto-Handa R, Takahadhi Y, Yoshizawa F, Aizawa S, Akanuma Y, Sonenberg N, Yazaki Y, Kadowaki T. Insulin signaling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol 1996, 16:3074-3084.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 3074-3084
-
-
Yamauchi, T.1
Tobe, K.2
Tamemoto, H.3
Ueki, K.4
Kaburagi, Y.5
Yamamoto-Handa, R.6
Takahadhi, Y.7
Yoshizawa, F.8
Aizawa, S.9
Akanuma, Y.10
Sonenberg, N.11
Yazaki, Y.12
Kadowaki, T.13
-
10
-
-
0032567937
-
Disruption of IRS 2 causes type 2 diabetes in mice
-
10 Withers DJ, Sanchez-Gutierrez JC, Towery H, Ren JM, Burks DJ, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF. Disruption of IRS 2 causes type 2 diabetes in mice. Nature 1998, 391:900-903. Disruption of IRS-2 causes both defects in insulin action in liver and muscle and also attenuates the beta-cell compensatory response to insulin resistance with the result that mice develop type 2 diabetes.
-
(1998)
Nature
, vol.391
, pp. 900-903
-
-
Withers, D.J.1
Sanchez-Gutierrez, J.C.2
Towery, H.3
Ren, J.M.4
Burks, D.J.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
Bonner-Weir, S.11
White, M.F.12
-
11
-
-
0032504257
-
Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes
-
11 Rother KI, Imai Y, Caruso M, Beguinot F, Formisano P, Accili D. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. J Biol Chem 1998, 273:17491-17497.
-
(1998)
J Biol Chem
, vol.273
, pp. 17491-17497
-
-
Rother, K.I.1
Imai, Y.2
Caruso, M.3
Beguinot, F.4
Formisano, P.5
Accili, D.6
-
12
-
-
0030927342
-
The β-cell transcription factors and development of the pancreas
-
12 Sander M, German MS. The β-cell transcription factors and development of the pancreas. J Mol Med 1997, 75:327-340.
-
(1997)
J Mol Med
, vol.75
, pp. 327-340
-
-
Sander, M.1
German, M.S.2
-
13
-
-
0032061042
-
Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase
-
13 Leibiger IB, Leibiger B, Moede T, Berggren PO. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase. Mol Cell 1998, 1:933-938. Insulin regulates the transcription of the insulin gene via the IRS-2 dependent signaling pathway.
-
(1998)
Mol Cell
, vol.1
, pp. 933-938
-
-
Leibiger, I.B.1
Leibiger, B.2
Moede, T.3
Berggren, P.O.4
-
14
-
-
0031823491
-
Insulin receptor signaling in the β-cell influences insulin gene expression and insulin content
-
14 Xu GG, Rothenberg PL. Insulin receptor signaling in the β-cell influences insulin gene expression and insulin content. Diabetes 1998, 47:1243-1252.
-
(1998)
Diabetes
, vol.47
, pp. 1243-1252
-
-
Xu, G.G.1
Rothenberg, P.L.2
-
15
-
-
0032504211
-
IGF-1 stimulated pancreatic β-cell growth is glucose dependent: Synergistic activation of IRS-mediated signal transduction pathways by glucose and IGF-1 in INS-1 cells
-
15 Hugl SR, White MF, Rhodes CJ. IGF-1 stimulated pancreatic β-cell growth is glucose dependent: Synergistic activation of IRS-mediated signal transduction pathways by glucose and IGF-1 in INS-1 cells. J Biol Chem 1998, 272:17771-17779.
-
(1998)
J Biol Chem
, vol.272
, pp. 17771-17779
-
-
Hugl, S.R.1
White, M.F.2
Rhodes, C.J.3
-
16
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in Type 2 diabetes
-
16 Kulkarni, RN, Bruning, JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in Type 2 diabetes. Cell 1999, 96:329-339. Beta cell specific deletion of the insulin receptor results in a first phase insulin secretory defect that resembles that seen in type 2 diabetes.
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Kahn, C.R.6
-
17
-
-
0030724591
-
Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
-
17 DeFronzo RA. Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes. Diabetes Rev 1997, 5:177-269.
-
(1997)
Diabetes Rev
, vol.5
, pp. 177-269
-
-
DeFronzo, R.A.1
-
18
-
-
0013563461
-
A muscle specific insulin receptor knockout challenges the current concepts of glucose disposal and NIDDM pathogenesis
-
18 Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, Accili D, Goodyear LJ, Kahn CR. A muscle specific insulin receptor knockout challenges the current concepts of glucose disposal and NIDDM pathogenesis. Mol Cell 1998, 2:569. Muscle specific deletion of the insulin receptor attenuates insulin signaling and action in muscle but does not result in diabetes.
-
(1998)
Mol Cell
, vol.2
, pp. 569
-
-
Bruning, J.C.1
Michael, M.D.2
Winnay, J.N.3
Hayashi, T.4
Horsch, D.5
Accili, D.6
Goodyear, L.J.7
Kahn, C.R.8
-
19
-
-
0031792118
-
Transgenic knockout mice with a targeted impairment of insulin action in skeletal muscle and adipose tissue
-
19 Laura, D., Kido, Y., Hayashi, H., Ebina, Y., and Accili, D. Transgenic knockout mice with a targeted impairment of insulin action in skeletal muscle and adipose tissue. Nature Genetics 1998, 20:294-298. Attenuation of insulin signaling in muscle and adipose tissue does not cause diabetes.
-
(1998)
Nature Genetics
, vol.20
, pp. 294-298
-
-
Laura, D.1
Kido, Y.2
Hayashi, H.3
Ebina, Y.4
Accili, D.5
|