메뉴 건너뛰기




Volumn 16, Issue 5, 2002, Pages 1189-1227

Development of matrix metalloproteinase inhibitors in cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

4 DEDIMETHYLAMINOSANCYCLINE; ANTINEOPLASTIC AGENT; BATIMASTAT; BB 2511; BISPHOSPHONIC ACID DERIVATIVE; CARBOPLATIN; CGS 27023A; CLODRONIC ACID; CORTICOSTEROID; CYTOTOXIC AGENT; DOXYCYCLINE; FLUOROURACIL; GEMCITABINE; MARIMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MMI 270B; NONSTEROID ANTIINFLAMMATORY AGENT; PACLITAXEL; PRINOMASTAT; REBIMASTAT; TANOMASTAT; TEMOZOLOMIDE; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG; PROTEINASE INHIBITOR; TUMOR PROTEIN;

EID: 0036817030     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8588(02)00044-8     Document Type: Review
Times cited : (22)

References (196)
  • 1
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers AF, Matrisian L. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997;89:1260-70.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.2
  • 2
    • 0033014166 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors in tumour growth and invasion
    • Kahari VM, Saarialho-Kere U. Matrix metalloproteinases and their inhibitors in tumour growth and invasion. Ann Med 1999;31:34-45.
    • (1999) Ann Med , vol.31 , pp. 34-45
    • Kahari, V.M.1    Saarialho-Kere, U.2
  • 3
    • 0028948844 scopus 로고
    • Gelatinase A activity directly modulates melanoma cell adhesion and spreading
    • Ray JM, Stetler-Stevenson WG. Gelatinase A activity directly modulates melanoma cell adhesion and spreading. EMBO J 1995;14:908-17.
    • (1995) EMBO J , vol.14 , pp. 908-917
    • Ray, J.M.1    Stetler-Stevenson, W.G.2
  • 5
    • 0030723230 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: Present achievements and future prospects
    • Denis LJ, Verweij J. Matrix metalloproteinase inhibitors: Present achievements and future prospects. Invest New Drugs 1997;15:175-85.
    • (1997) Invest New Drugs , vol.15 , pp. 175-185
    • Denis, L.J.1    Verweij, J.2
  • 7
    • 0033034041 scopus 로고    scopus 로고
    • Clinical studies with matrix metalloproteinase inhibitors
    • Brown PD. Clinical studies with matrix metalloproteinase inhibitors. APMIS 1999;107: 174-80.
    • (1999) APMIS , vol.107 , pp. 174-180
    • Brown, P.D.1
  • 8
    • 0003089209 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase gene expression
    • Parks W, Mechan R, editors. San Diego: Academic Press
    • Fini ME, Cook JR, Mohan R, Brinckerhoff CE. Regulation of matrix metalloproteinase gene expression. In: Parks W, Mechan R, editors. Matrix Metalloproteinases. San Diego: Academic Press, 1998. p. 300-56.
    • (1998) Matrix Metalloproteinases , pp. 300-356
    • Fini, M.E.1    Cook, J.R.2    Mohan, R.3    Brinckerhoff, C.E.4
  • 9
    • 0031671855 scopus 로고    scopus 로고
    • Matrix metalloproteinase degradation of extracellular matrix: Biological consequences
    • Shapiro SD. Matrix metalloproteinase degradation of extracellular matrix: Biological consequences. Curr Opin Cell Biol 1998;10:602-8.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 602-608
    • Shapiro, S.D.1
  • 10
    • 0029876809 scopus 로고    scopus 로고
    • Stimulation of gelatinase B and tissue inhibitors of metalloproteinase (TIMP) production in co-culture of human osteosarcoma cells and human fibroblasts: Gelatinase B production was stimulated via up-regulation of fibroblast growth factor (FGF) receptor
    • Kurogi T, Nabeshima K, Kataoka H, Okada Y, Koono M. Stimulation of gelatinase B and tissue inhibitors of metalloproteinase (TIMP) production in co-culture of human osteosarcoma cells and human fibroblasts: Gelatinase B production was stimulated via up-regulation of fibroblast growth factor (FGF) receptor. Int J Cancer 1996;66:82-90.
    • (1996) Int J Cancer , vol.66 , pp. 82-90
    • Kurogi, T.1    Nabeshima, K.2    Kataoka, H.3    Okada, Y.4    Koono, M.5
  • 11
    • 0030888746 scopus 로고    scopus 로고
    • Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells
    • Kondapaka SB, Fridman R, Reddy KB. Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells. Int J Cancer 1997;70: 722-6.
    • (1997) Int J Cancer , vol.70 , pp. 722-726
    • Kondapaka, S.B.1    Fridman, R.2    Reddy, K.B.3
  • 12
    • 0030917658 scopus 로고    scopus 로고
    • In situ detection of PCR-amplified metalloproteinase cDNAs, their inhibitors and human papillomavirus transcripts in cervical carcinoma cell lines
    • Nuovo GJ. In situ detection of PCR-amplified metalloproteinase cDNAs, their inhibitors and human papillomavirus transcripts in cervical carcinoma cell lines. Int J Cancer 1997;71: 1056-60.
    • (1997) Int J Cancer , vol.71 , pp. 1056-1060
    • Nuovo, G.J.1
  • 13
    • 0031471249 scopus 로고    scopus 로고
    • In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor
    • Panck RL, Lu GH, Klutchko SR, Batley BL, Dahring TK, Hamby JM, et al. In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J Pharmacol Exp Ther 1997;283:1433-44.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1433-1444
    • Panck, R.L.1    Lu, G.H.2    Klutchko, S.R.3    Batley, B.L.4    Dahring, T.K.5    Hamby, J.M.6
  • 14
    • 0033053127 scopus 로고    scopus 로고
    • Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9
    • Mira E, Manes S, Lacalle RA, Marquez G, Martinez A. Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9. Endocrinology 1999; 140:1657-64.
    • (1999) Endocrinology , vol.140 , pp. 1657-1664
    • Mira, E.1    Manes, S.2    Lacalle, R.A.3    Marquez, G.4    Martinez, A.5
  • 15
    • 0032533511 scopus 로고    scopus 로고
    • Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells
    • Rosenthal EL, Johnson TM, Allen ED, Apel IJ, Punturieri A, Weiss SJ. Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells. Cancer Res 1998;58:5221-30.
    • (1998) Cancer Res , vol.58 , pp. 5221-5230
    • Rosenthal, E.L.1    Johnson, T.M.2    Allen, E.D.3    Apel, I.J.4    Punturieri, A.5    Weiss, S.J.6
  • 16
    • 0032578691 scopus 로고    scopus 로고
    • Proteinase requirements of epidermal growth factor-induced ovarian cancer cell invasion
    • Ellerbroek SM, Hudson LG, Stack MS. Proteinase requirements of epidermal growth factor-induced ovarian cancer cell invasion. Int J Cancer 1998;78:331-7.
    • (1998) Int J Cancer , vol.78 , pp. 331-337
    • Ellerbroek, S.M.1    Hudson, L.G.2    Stack, M.S.3
  • 17
    • 0032807991 scopus 로고    scopus 로고
    • EGF induces the expression of matrilysin in the human prostate adenocarcinoma cell line, LNCaP
    • Sundareshan P, Nagle RB, Bowden GT. EGF induces the expression of matrilysin in the human prostate adenocarcinoma cell line, LNCaP. Prostate 1999;40:159-66.
    • (1999) Prostate , vol.40 , pp. 159-166
    • Sundareshan, P.1    Nagle, R.B.2    Bowden, G.T.3
  • 18
    • 0032983385 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells
    • Duivenvoorden WC, Hirte HW, Singh G. Transforming growth factor beta 1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. Clin Exp Metastasis 1999;17:27-34.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 27-34
    • Duivenvoorden, W.C.1    Hirte, H.W.2    Singh, G.3
  • 19
    • 0033562364 scopus 로고    scopus 로고
    • Growth factors and cytokines upregulate gclatinase expression in bone marrow CD34(+) cells and their transmigration through reconstituted basement membrane
    • Janowska-Wieczorek A, Marquez LA, Nabholtz JM, Cabuhat ML, Montano J, Chang H, et al. Growth factors and cytokines upregulate gclatinase expression in bone marrow CD34(+) cells and their transmigration through reconstituted basement membrane. Blood 1999;93:3379-90.
    • (1999) Blood , vol.93 , pp. 3379-3390
    • Janowska-Wieczorek, A.1    Marquez, L.A.2    Nabholtz, J.M.3    Cabuhat, M.L.4    Montano, J.5    Chang, H.6
  • 20
    • 0032520784 scopus 로고    scopus 로고
    • Bi-directional induction of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 during T lymphoma/endothelial cell contact: Implication of ICAM-1
    • Aoudjit F, Potworowski EF, St-Pierre Y. Bi-directional induction of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 during T lymphoma/endothelial cell contact: Implication of ICAM-1. J Immunol 1998;160:2967-73.
    • (1998) J Immunol , vol.160 , pp. 2967-2973
    • Aoudjit, F.1    Potworowski, E.F.2    St-Pierre, Y.3
  • 21
    • 0033050405 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells
    • Reddy KB, Krueger JS, Kondapaka SB, Diglio CA. Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells. Int J Cancer 1999;82:268-73.
    • (1999) Int J Cancer , vol.82 , pp. 268-273
    • Reddy, K.B.1    Krueger, J.S.2    Kondapaka, S.B.3    Diglio, C.A.4
  • 22
    • 0030756920 scopus 로고    scopus 로고
    • Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion
    • Sato H, Okada Y, Seiki M. Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion. Thromb Haemost 1997;78:497-500.
    • (1997) Thromb Haemost , vol.78 , pp. 497-500
    • Sato, H.1    Okada, Y.2    Seiki, M.3
  • 24
    • 0030717692 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions
    • Gomez DE, Alonso DF, Yoshiji H, Thorgeirsson UP. Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions. Eur J Cell Biol 1997;74:111-22.
    • (1997) Eur J Cell Biol , vol.74 , pp. 111-122
    • Gomez, D.E.1    Alonso, D.F.2    Yoshiji, H.3    Thorgeirsson, U.P.4
  • 25
    • 0033003988 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases (TIMP) in invasion and proliferation
    • Henriet P, Blavier L, DeClerck YA. Tissue inhibitors of metalloproteinases (TIMP) in invasion and proliferation. APMIS 1999;107:111-9.
    • (1999) APMIS , vol.107 , pp. 111-119
    • Henriet, P.1    Blavier, L.2    DeClerck, Y.A.3
  • 27
    • 0030016342 scopus 로고    scopus 로고
    • The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolitic activation
    • Will H, Atkinson S, Butler G, Smith B, Murphy G. The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolitic activation. J Biol Chem 1996;271:17119-23.
    • (1996) J Biol Chem , vol.271 , pp. 17119-17123
    • Will, H.1    Atkinson, S.2    Butler, G.3    Smith, B.4    Murphy, G.5
  • 28
    • 0344936742 scopus 로고    scopus 로고
    • IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice: IL-10 stimulation of TIMP-1 and inhibition of MMP-2/MMP-9 expression
    • Steams ME, Fudge K, Garcia F, Wang M. IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice: IL-10 stimulation of TIMP-1 and inhibition of MMP-2/MMP-9 expression. Invasion Metastasis 1997;17:62-74.
    • (1997) Invasion Metastasis , vol.17 , pp. 62-74
    • Steams, M.E.1    Fudge, K.2    Garcia, F.3    Wang, M.4
  • 29
    • 0032531277 scopus 로고    scopus 로고
    • Up-regulation of tissue inhibitor of metal-loproteinases-3 gene expression by TGF-beta in articular chondrocytes is mediated by serine/ threonine and tyrosine kinases
    • Su S, DiBattista JA, Sun Y, Li WQ, Zafarullah M. Up-regulation of tissue inhibitor of metal-loproteinases-3 gene expression by TGF-beta in articular chondrocytes is mediated by serine/ threonine and tyrosine kinases. J Cell Biochcm 1998;70:517-27.
    • (1998) J Cell Biochcm , vol.70 , pp. 517-527
    • Su, S.1    DiBattista, J.A.2    Sun, Y.3    Li, W.Q.4    Zafarullah, M.5
  • 30
    • 0032953206 scopus 로고    scopus 로고
    • Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion
    • Steams ME, Rhim J, Wang M. Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion. Clin Cancer Res 1999;5:189-96.
    • (1999) Clin Cancer Res , vol.5 , pp. 189-196
    • Steams, M.E.1    Rhim, J.2    Wang, M.3
  • 31
    • 0029919115 scopus 로고    scopus 로고
    • TIMP-2 growth-stimulatory activity: A concentration and cell type specific response in the presence of insulin
    • Nemeth J, Rafe A, Steiner M, Goolsby C. TIMP-2 growth-stimulatory activity: A concentration and cell type specific response in the presence of insulin. Exp Cell Res 1996;224:110-5.
    • (1996) Exp Cell Res , vol.224 , pp. 110-115
    • Nemeth, J.1    Rafe, A.2    Steiner, M.3    Goolsby, C.4
  • 32
    • 0029836160 scopus 로고    scopus 로고
    • Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice
    • Martin D, Ruther U, Sanchez-Sweatman O, Orr W, Khokha R. Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice. Oncogene 1996;13:569-76.
    • (1996) Oncogene , vol.13 , pp. 569-576
    • Martin, D.1    Ruther, U.2    Sanchez-Sweatman, O.3    Orr, W.4    Khokha, R.5
  • 34
    • 0032484529 scopus 로고    scopus 로고
    • Mammary carcinoma cells overexpressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression
    • Yoshiji H, Harris S, Raso E, Gomey D, Lindsay C, Shibuya M. Mammary carcinoma cells overexpressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression. Int J Cancer 1998;247:81-7.
    • (1998) Int J Cancer , vol.247 , pp. 81-87
    • Yoshiji, H.1    Harris, S.2    Raso, E.3    Gomey, D.4    Lindsay, C.5    Shibuya, M.6
  • 35
    • 0033003771 scopus 로고    scopus 로고
    • Membrane-type matrix metalloproteinase
    • Seiki M. Membrane-type matrix metalloproteinase. APMIS 1999;107:137-43.
    • (1999) APMIS , vol.107 , pp. 137-143
    • Seiki, M.1
  • 36
    • 0033039398 scopus 로고    scopus 로고
    • An odyssey from breast to bone: Multiple-step control of mammary metastases and osteolysis by matrix metalloproteinases
    • Lochter A, Bissell M. An odyssey from breast to bone: Multiple-step control of mammary metastases and osteolysis by matrix metalloproteinases. APMIS 1999;107:128-36.
    • (1999) APMIS , vol.107 , pp. 128-136
    • Lochter, A.1    Bissell, M.2
  • 37
    • 84975525035 scopus 로고
    • Seminars in medicine of the Best Israel Hospital, Boston. Clinical applications of research on angiogenesis
    • Folkman J. Seminars in medicine of the Best Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med 1995;333:1757-63.
    • (1995) N Engl J Med , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 38
    • 0028346025 scopus 로고
    • Direct evidence linking expression of matrix metal-loproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells
    • Bernhard EJ, Gruber SB, Muschel RJ. Direct evidence linking expression of matrix metal-loproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci U S A 1994;91:4293-7.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 4293-4297
    • Bernhard, E.J.1    Gruber, S.B.2    Muschel, R.J.3
  • 39
    • 0029824947 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system
    • Hua J, Muschel RJ. Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system. Cancer Res 1996;56:5279-84.
    • (1996) Cancer Res , vol.56 , pp. 5279-5284
    • Hua, J.1    Muschel, R.J.2
  • 40
    • 0028845849 scopus 로고
    • Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase A
    • Kawamata H, Kameyama S, Kawai K, Tanaka Y, Nan L, Barch D. Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase A. Int J Cancer 1995;63:568-75.
    • (1995) Int J Cancer , vol.63 , pp. 568-575
    • Kawamata, H.1    Kameyama, S.2    Kawai, K.3    Tanaka, Y.4    Nan, L.5    Barch, D.6
  • 41
    • 0029753004 scopus 로고    scopus 로고
    • Expression of membrane-type matrix metalloproteinase 1 (MTI-MMP) in tumor cells enhances pulmonary metastases in an experimental metastasis assay
    • Tsunezuka Y, Kinoh H, Takino T, Watanabe Y, Okada Y, Shinagawa A. Expression of membrane-type matrix metalloproteinase 1 (MTI-MMP) in tumor cells enhances pulmonary metastases in an experimental metastasis assay. Cancer Res 1996;63:5678-83.
    • (1996) Cancer Res , vol.63 , pp. 5678-5683
    • Tsunezuka, Y.1    Kinoh, H.2    Takino, T.3    Watanabe, Y.4    Okada, Y.5    Shinagawa, A.6
  • 42
    • 0027530706 scopus 로고
    • Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in several combined immunodeficient mice
    • Powel W, Knox J, Navre M, Grogan T, Kittelson J, Nagle RB. Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in several combined immunodeficient mice. Cancer Res 1993;53:417-22.
    • (1993) Cancer Res , vol.53 , pp. 417-422
    • Powel, W.1    Knox, J.2    Navre, M.3    Grogan, T.4    Kittelson, J.5    Nagle, R.B.6
  • 44
    • 0032031861 scopus 로고    scopus 로고
    • Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
    • Itoh H, Tanioka M, Yoshida H, Yoshioka T, Nishimoto H. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res 1998;58:1048-51.
    • (1998) Cancer Res , vol.58 , pp. 1048-1051
    • Itoh, H.1    Tanioka, M.2    Yoshida, H.3    Yoshioka, T.4    Nishimoto, H.5
  • 45
    • 0032559821 scopus 로고    scopus 로고
    • In vivo evidence that the stromeysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy
    • Masson R, Lefebvre O, Noel A, Fahime M, Chenard MP, Wendling C. In vivo evidence that the stromeysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. J Cell Biol 1998;140:1535-41.
    • (1998) J Cell Biol , vol.140 , pp. 1535-1541
    • Masson, R.1    Lefebvre, O.2    Noel, A.3    Fahime, M.4    Chenard, M.P.5    Wendling, C.6
  • 46
    • 0033598169 scopus 로고    scopus 로고
    • Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1
    • Martin DC, Fowlkes JL, Babic B, Khokha R. Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1. J Cell Biol 1999;146:881-92.
    • (1999) J Cell Biol , vol.146 , pp. 881-892
    • Martin, D.C.1    Fowlkes, J.L.2    Babic, B.3    Khokha, R.4
  • 47
    • 0040776938 scopus 로고    scopus 로고
    • Identification of insulin like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3
    • Manes S, Mira E, Barbacid M, Cipres A, Fernandez-Resa P, Buesa J, et al. Identification of insulin like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3. J Biol Chem 1997;272:25706-12.
    • (1997) J Biol Chem , vol.272 , pp. 25706-25712
    • Manes, S.1    Mira, E.2    Barbacid, M.3    Cipres, A.4    Fernandez-Resa, P.5    Buesa, J.6
  • 49
  • 50
    • 0008427936 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-1 in human prostate
    • Hashimoto K, Kihira Y, Matuo Y, Usui T. Expression of matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-1 in human prostate. J Urol 1998;160:1872-6.
    • (1998) J Urol , vol.160 , pp. 1872-1876
    • Hashimoto, K.1    Kihira, Y.2    Matuo, Y.3    Usui, T.4
  • 51
    • 0031800115 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis
    • Sutinen M, Kainulainen T, Hurskainen T, Vesterlund E, Alexander JP, Overall CM, et al. Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. Br J Cancer 1998;77:2239-45.
    • (1998) Br J Cancer , vol.77 , pp. 2239-2245
    • Sutinen, M.1    Kainulainen, T.2    Hurskainen, T.3    Vesterlund, E.4    Alexander, J.P.5    Overall, C.M.6
  • 52
    • 0031935056 scopus 로고    scopus 로고
    • 72-kD (MMP-2) and 92-kD (MMP-9) type IV collagenase production and activity in different histologic types of lung cancer cells
    • Gonzalez-Avila G, Iturria C, Vadillo F, Teran L, Selman M, Perez-Tamayo R. 72-kD (MMP-2) and 92-kD (MMP-9) type IV collagenase production and activity in different histologic types of lung cancer cells. Pathobiology 1998;66:5-16.
    • (1998) Pathobiology , vol.66 , pp. 5-16
    • Gonzalez-Avila, G.1    Iturria, C.2    Vadillo, F.3    Teran, L.4    Selman, M.5    Perez-Tamayo, R.6
  • 53
    • 0030785679 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: Quantificative and morphological analyses
    • Nawrocki B, Polette M, Marchand V, Monteau M, Gillery P, Toumier JM, et al. Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: Quantificative and morphological analyses. Int J Cancer 1997;72:556-64.
    • (1997) Int J Cancer , vol.72 , pp. 556-564
    • Nawrocki, B.1    Polette, M.2    Marchand, V.3    Monteau, M.4    Gillery, P.5    Toumier, J.M.6
  • 54
    • 65749308863 scopus 로고    scopus 로고
    • The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application
    • Bramhall SR. The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application. Int J Pancreatol 1997;21:1-12.
    • (1997) Int J Pancreatol , vol.21 , pp. 1-12
    • Bramhall, S.R.1
  • 55
    • 0032836427 scopus 로고    scopus 로고
    • Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications
    • Zucker S, Hymowitz M, Conner C, Zarrabi HM, Hurewitz AN, Matrisian L, et al. Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications. Ann N Y Acad Sci 1999;878:212-27.
    • (1999) Ann N Y Acad Sci , vol.878 , pp. 212-227
    • Zucker, S.1    Hymowitz, M.2    Conner, C.3    Zarrabi, H.M.4    Hurewitz, A.N.5    Matrisian, L.6
  • 56
    • 0001071353 scopus 로고    scopus 로고
    • Cancer invasion and tissue remodeling-cooperation of protease systems and cell types
    • Dano K, Romer J, Nielsen B, Bjom S, Pyke C, Rygaard J, et al. Cancer invasion and tissue remodeling-cooperation of protease systems and cell types. APMIS 1999;107:120-7.
    • (1999) APMIS , vol.107 , pp. 120-127
    • Dano, K.1    Romer, J.2    Nielsen, B.3    Bjom, S.4    Pyke, C.5    Rygaard, J.6
  • 57
    • 0000683771 scopus 로고    scopus 로고
    • Expression of most matrixmetalloproteinase family members in breast cancer represents a tumor-induced host response
    • Johansonn N, Airola K, Grenman R, Kariniemi AL, Saarialho-Kere U, Kahari VM. Expression of most matrixmetalloproteinase family members in breast cancer represents a tumor-induced host response. Am J Pathol 1997;151:273-89.
    • (1997) Am J Pathol , vol.151 , pp. 273-289
    • Johansonn, N.1    Airola, K.2    Grenman, R.3    Kariniemi, A.L.4    Saarialho-Kere, U.5    Kahari, V.M.6
  • 58
    • 0040351696 scopus 로고    scopus 로고
    • Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal epithelial cell interactions
    • Uria A, Stahle-Backdahl M, Seiki M, Fueyo A, Lopez-Otin C. Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal epithelial cell interactions. Cancer Res 1997;57:4882-8.
    • (1997) Cancer Res , vol.57 , pp. 4882-4888
    • Uria, A.1    Stahle-Backdahl, M.2    Seiki, M.3    Fueyo, A.4    Lopez-Otin, C.5
  • 59
    • 0029946569 scopus 로고    scopus 로고
    • Expression of most matrix metalloproteinases family members in breast cancer represents a tumor-induced host response
    • Heppner KJ, Matrisian LM, Jensen RA, Rodgers WH. Expression of most matrix metalloproteinases family members in breast cancer represents a tumor-induced host response. Am J Pathol 1996;149:273-82.
    • (1996) Am J Pathol , vol.149 , pp. 273-282
    • Heppner, K.J.1    Matrisian, L.M.2    Jensen, R.A.3    Rodgers, W.H.4
  • 60
    • 0032895321 scopus 로고    scopus 로고
    • Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas
    • Airola K, Karonen T, Vaalamo M, Lehti K, Lohi J, Kariniemi AL, et al. Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas. Br J Cancer 1999;80:733-43.
    • (1999) Br J Cancer , vol.80 , pp. 733-743
    • Airola, K.1    Karonen, T.2    Vaalamo, M.3    Lehti, K.4    Lohi, J.5    Kariniemi, A.L.6
  • 61
    • 0032867683 scopus 로고    scopus 로고
    • Role of matrix metalloproteinase-9 in the basement membrane destruction of superficial urothelial carcinomas
    • Ozdemir E, Kakehi Y, Okuno H, Yoshida O. Role of matrix metalloproteinase-9 in the basement membrane destruction of superficial urothelial carcinomas. J Urol 1999;161:1359-63.
    • (1999) J Urol , vol.161 , pp. 1359-1363
    • Ozdemir, E.1    Kakehi, Y.2    Okuno, H.3    Yoshida, O.4
  • 62
    • 0032927440 scopus 로고    scopus 로고
    • "Proteolytic switching": Opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression
    • MacDougall JR, Bani MR, Lin Y, Muschel RJ, Kerbel RS. "Proteolytic switching": Opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression. Br J Cancer 1999;80:504-12.
    • (1999) Br J Cancer , vol.80 , pp. 504-512
    • MacDougall, J.R.1    Bani, M.R.2    Lin, Y.3    Muschel, R.J.4    Kerbel, R.S.5
  • 63
    • 0030037734 scopus 로고    scopus 로고
    • Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas
    • Iwata H, Kobayashi S, Iwase H, Masaoka A, Fujimoto N, Okada Y. Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas. Jpn J Cancer Res 1996;87:602-11.
    • (1996) Jpn J Cancer Res , vol.87 , pp. 602-611
    • Iwata, H.1    Kobayashi, S.2    Iwase, H.3    Masaoka, A.4    Fujimoto, N.5    Okada, Y.6
  • 64
    • 0038192185 scopus 로고    scopus 로고
    • Different expression patterns of MMP-2 and MMP-9 in breast cancer
    • Rha SY, Yang WI, Kim JH, Roh JK, Min JS, Lee KS, et al. Different expression patterns of MMP-2 and MMP-9 in breast cancer. Oncol Rep 1998;5:875-9.
    • (1998) Oncol Rep , vol.5 , pp. 875-879
    • Rha, S.Y.1    Yang, W.I.2    Kim, J.H.3    Roh, J.K.4    Min, J.S.5    Lee, K.S.6
  • 66
    • 0029952713 scopus 로고    scopus 로고
    • Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer
    • Murray GI, Duncan ME, O'Neil P, Melvin WT, Fothergill JE. Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nat Med 1996;2:461-2.
    • (1996) Nat Med , vol.2 , pp. 461-462
    • Murray, G.I.1    Duncan, M.E.2    O'Neil, P.3    Melvin, W.T.4    Fothergill, J.E.5
  • 67
    • 0033565257 scopus 로고    scopus 로고
    • Association of matrylisin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma
    • Yamamoto H, Adachi Y, Itoh F, Iku S, Matsuno K, Kusano M, et al. Association of matrylisin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma. Cancer Res 1999;59:3313-6.
    • (1999) Cancer Res , vol.59 , pp. 3313-3316
    • Yamamoto, H.1    Adachi, Y.2    Itoh, F.3    Iku, S.4    Matsuno, K.5    Kusano, M.6
  • 69
    • 0031431887 scopus 로고    scopus 로고
    • Inhibition of tumor promoter activity toward mouse fibroblasts and their in vitro transformation by tissue inhibitor of metalloproteinases-1 (TIMP-1)
    • Shoji A, Sakamoto Y, Tsuchiya T, Moriyama K, Kaneko T, Okubo T, et al. Inhibition of tumor promoter activity toward mouse fibroblasts and their in vitro transformation by tissue inhibitor of metalloproteinases-1 (TIMP-1). Carcinogenesis 1997;18:2093-100.
    • (1997) Carcinogenesis , vol.18 , pp. 2093-2100
    • Shoji, A.1    Sakamoto, Y.2    Tsuchiya, T.3    Moriyama, K.4    Kaneko, T.5    Okubo, T.6
  • 70
    • 0032493066 scopus 로고    scopus 로고
    • Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line
    • Kruger A, Sanchez-Sweatman OH, Martin DC, Fata JE, Ho AT, Orr FW, et al. Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line. Oncogene 1998;16:2419-23.
    • (1998) Oncogene , vol.16 , pp. 2419-2423
    • Kruger, A.1    Sanchez-Sweatman, O.H.2    Martin, D.C.3    Fata, J.E.4    Ho, A.T.5    Orr, F.W.6
  • 71
    • 0028129494 scopus 로고
    • Overexpression of metalloproteinase inhibitor in B161710 melanoma cells does not affect extravasation but reduces tumor growth
    • Koop S, Khokha R, Schmidt EE, MacDonald IC, Morris VL, Chambers AF. Overexpression of metalloproteinase inhibitor in B161710 melanoma cells does not affect extravasation but reduces tumor growth. Cancer Res 1994;54:4791-7.
    • (1994) Cancer Res , vol.54 , pp. 4791-4797
    • Koop, S.1    Khokha, R.2    Schmidt, E.E.3    MacDonald, I.C.4    Morris, V.L.5    Chambers, A.F.6
  • 72
    • 0030801093 scopus 로고    scopus 로고
    • Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma
    • Bramhall SR, Neoptolemos JP, Stamp GW, Lemoine NR. Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. J Pathol 1997;182:347-55.
    • (1997) J Pathol , vol.182 , pp. 347-355
    • Bramhall, S.R.1    Neoptolemos, J.P.2    Stamp, G.W.3    Lemoine, N.R.4
  • 73
    • 0029079752 scopus 로고
    • Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with kymph nodes and distinct metastasis
    • Zeng Z, Cohen A, Zhang Z, Stetler-Stevenson W, Guillem J. Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with kymph nodes and distinct metastasis. Clin Cancer Res 1995;1:899-906.
    • (1995) Clin Cancer Res , vol.1 , pp. 899-906
    • Zeng, Z.1    Cohen, A.2    Zhang, Z.3    Stetler-Stevenson, W.4    Guillem, J.5
  • 74
    • 0029737908 scopus 로고    scopus 로고
    • TIMP-1 and adverse prognosis in non-small cell lung cancer
    • Fong K, Kida Y, Zimmermann P, Smith P. TIMP-1 and adverse prognosis in non-small cell lung cancer. Clin Cancer Res 1996;2:1364-72.
    • (1996) Clin Cancer Res , vol.2 , pp. 1364-1372
    • Fong, K.1    Kida, Y.2    Zimmermann, P.3    Smith, P.4
  • 75
    • 0030904714 scopus 로고    scopus 로고
    • TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma
    • Powe D, Brough J, Carter G, Ravery V, Angulo J, Shamsa F. TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma. Br J Cancer 1997;75:1678-83.
    • (1997) Br J Cancer , vol.75 , pp. 1678-1683
    • Powe, D.1    Brough, J.2    Carter, G.3    Ravery, V.4    Angulo, J.5    Shamsa, F.6
  • 76
    • 0028100681 scopus 로고
    • Expression and localization of matrix degrading metalloproteinases during colorectal tumorigenesis
    • Newell K, Witty J, Rodgers W, Matrisian L. Expression and localization of matrix degrading metalloproteinases during colorectal tumorigenesis. Mol Carcinog 1994;10: 199-206.
    • (1994) Mol Carcinog , vol.10 , pp. 199-206
    • Newell, K.1    Witty, J.2    Rodgers, W.3    Matrisian, L.4
  • 77
    • 0029977663 scopus 로고    scopus 로고
    • Enhanced RNA expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human breast cancer
    • Yoshiji H, Gomez D, Horgeirsson U. Enhanced RNA expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human breast cancer. Br J Cancer 1996;69:131-4.
    • (1996) Br J Cancer , vol.69 , pp. 131-134
    • Yoshiji, H.1    Gomez, D.2    Horgeirsson, U.3
  • 78
    • 0031436132 scopus 로고    scopus 로고
    • Association of expression of metalloproteinases and their inhibitors with the metastatic potential of squamous lung carcinomas
    • Karameris A, Panagou P, Tsilalis T, Bouros D. Association of expression of metalloproteinases and their inhibitors with the metastatic potential of squamous lung carcinomas. Am J Respir Crit Care Med 1997;156:1930-6.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1930-1936
    • Karameris, A.1    Panagou, P.2    Tsilalis, T.3    Bouros, D.4
  • 79
    • 0032963210 scopus 로고    scopus 로고
    • High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer
    • McCarthy K, Maguire T, McGreal G, McDermott E, O'Higgins N, Duffy MJ. High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer. Int J Cancer 1999;84:44-8.
    • (1999) Int J Cancer , vol.84 , pp. 44-48
    • McCarthy, K.1    Maguire, T.2    McGreal, G.3    McDermott, E.4    O'Higgins, N.5    Duffy, M.J.6
  • 80
    • 0032520916 scopus 로고    scopus 로고
    • Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion
    • Simon C, Goepfert H, Boyd D. Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion. Cancer Res 1998;58:1135-9.
    • (1998) Cancer Res , vol.58 , pp. 1135-1139
    • Simon, C.1    Goepfert, H.2    Boyd, D.3
  • 81
    • 0030468743 scopus 로고    scopus 로고
    • Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase, on urokinase expression and in vitro invasion
    • Simon C, Juarez J, Nicolson GL, Boyd D. Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase, on urokinase expression and in vitro invasion. Cancer Res 1996;56: 5369-74.
    • (1996) Cancer Res , vol.56 , pp. 5369-5374
    • Simon, C.1    Juarez, J.2    Nicolson, G.L.3    Boyd, D.4
  • 82
    • 0032503544 scopus 로고    scopus 로고
    • Matrylysin-specific antisense oligonucleotide inhibits liver metastasis of human colon cancer cells in a nude mouse model
    • Hasegawa S, Koshikawa N, Momiyama N, Moriyama K, Ichikawa Y, Ichikawa I. Matrylysin-specific antisense oligonucleotide inhibits liver metastasis of human colon cancer cells in a nude mouse model. Int J Cancer 1998;76:812-6.
    • (1998) Int J Cancer , vol.76 , pp. 812-816
    • Hasegawa, S.1    Koshikawa, N.2    Momiyama, N.3    Moriyama, K.4    Ichikawa, Y.5    Ichikawa, I.6
  • 83
    • 0032101072 scopus 로고    scopus 로고
    • Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinase-3 inhibits invasion and induces apoptosis in melanoma cells
    • Ahonen M, Baker AH, Kahari VM. Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinase-3 inhibits invasion and induces apoptosis in melanoma cells. Cancer Res 1998;58:2310-5.
    • (1998) Cancer Res , vol.58 , pp. 2310-2315
    • Ahonen, M.1    Baker, A.H.2    Kahari, V.M.3
  • 84
    • 0029810478 scopus 로고    scopus 로고
    • Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinase-3 (TIMP-3)
    • Bian J, Wang Y, Smith M, Kim H, Jacobs C, Jackman J. Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinase-3 (TIMP-3). Carcinogenesis 1996;17:1805-11.
    • (1996) Carcinogenesis , vol.17 , pp. 1805-1811
    • Bian, J.1    Wang, Y.2    Smith, M.3    Kim, H.4    Jacobs, C.5    Jackman, J.6
  • 85
    • 0032439091 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors
    • Brown PD. Matrix metalloproteinase inhibitors. Breast Cancer Res Treat 1998;52:125-36.
    • (1998) Breast Cancer Res Treat , vol.52 , pp. 125-136
    • Brown, P.D.1
  • 86
    • 0030609810 scopus 로고    scopus 로고
    • 1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile
    • Betz M, Huxley P, Davies SJ, Mushtaq Y, Pieper M, Tschesche H, et al. 1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile. Eur J Biochem 1997;247:356-63.
    • (1997) Eur J Biochem , vol.247 , pp. 356-363
    • Betz, M.1    Huxley, P.2    Davies, S.J.3    Mushtaq, Y.4    Pieper, M.5    Tschesche, H.6
  • 87
    • 0027994031 scopus 로고
    • Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spreads in a patient-like orthotopic model in nude mice
    • Wang X, Fu X, Brown P, Crimmin M, Hoffman RM. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spreads in a patient-like orthotopic model in nude mice. Cancer Res 1994;54:4726-8.
    • (1994) Cancer Res , vol.54 , pp. 4726-4728
    • Wang, X.1    Fu, X.2    Brown, P.3    Crimmin, M.4    Hoffman, R.M.5
  • 88
    • 0031669587 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase inhibitor BB-94 on liver cancer growth and metastasis in a patient-like orthotopic model LCI-D20
    • Bu W, Tang ZY, Sun FX, Ye SL, Liu KD, Xue Q, et al. Effects of matrix metalloproteinase inhibitor BB-94 on liver cancer growth and metastasis in a patient-like orthotopic model LCI-D20. Hepatogastroenterology 1998;45:1056-61.
    • (1998) Hepatogastroenterology , vol.45 , pp. 1056-1061
    • Bu, W.1    Tang, Z.Y.2    Sun, F.X.3    Ye, S.L.4    Liu, K.D.5    Xue, Q.6
  • 89
    • 0028939303 scopus 로고
    • Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrixmetalloproteinases
    • Taraboletti G, Garofalo A, Belotti D, Drudis T, Borsotti P, Scanziani E, et al. Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrixmetalloproteinases. J Natl Cancer Inst 1995;87:293-8.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 293-298
    • Taraboletti, G.1    Garofalo, A.2    Belotti, D.3    Drudis, T.4    Borsotti, P.5    Scanziani, E.6
  • 90
    • 0031148314 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo
    • Zervos EE, Norman JG, Gower WR, Franz MG, Rosemurgy AS. Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo. J Surg Res 1997;69:367-71.
    • (1997) J Surg Res , vol.69 , pp. 367-371
    • Zervos, E.E.1    Norman, J.G.2    Gower, W.R.3    Franz, M.G.4    Rosemurgy, A.S.5
  • 91
    • 0028129059 scopus 로고
    • Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinases
    • Chirivi R, Garofalo A, Crimmin M, Bawden L, Stoppacciaro A, Brown P, et al. Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinases. Int J Cancer 1994;58:460-4.
    • (1994) Int J Cancer , vol.58 , pp. 460-464
    • Chirivi, R.1    Garofalo, A.2    Crimmin, M.3    Bawden, L.4    Stoppacciaro, A.5    Brown, P.6
  • 92
    • 0029165411 scopus 로고
    • Inhibition of organ invasion by matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models
    • Watson SA, Morris T, Robinson G, Crimmin M, Brown PD, Hardcastle J. Inhibition of organ invasion by matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models. Cancer Res 1995;55:3629-33.
    • (1995) Cancer Res , vol.55 , pp. 3629-3633
    • Watson, S.A.1    Morris, T.2    Robinson, G.3    Crimmin, M.4    Brown, P.D.5    Hardcastle, J.6
  • 93
    • 0029934985 scopus 로고    scopus 로고
    • Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94)
    • Eccles SA, Box GM, Court WJ, Bone EA, Thomas W, Brown PD. Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94). Cancer Res 1996;56:2815-22.
    • (1996) Cancer Res , vol.56 , pp. 2815-2822
    • Eccles, S.A.1    Box, G.M.2    Court, W.J.3    Bone, E.A.4    Thomas, W.5    Brown, P.D.6
  • 94
    • 0032782424 scopus 로고    scopus 로고
    • The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells
    • Wylie S, MacDonald IC, Varghese HJ, Schmidt EE, Morris VL, Groom AC, et al. The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells. Clin Exp Metastasis 1999;17:111-7.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 111-117
    • Wylie, S.1    MacDonald, I.C.2    Varghese, H.J.3    Schmidt, E.E.4    Morris, V.L.5    Groom, A.C.6
  • 95
    • 0027251836 scopus 로고
    • A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian cancer xenografts
    • Davies BD, Brown P, East N, Crimmin M, Balkwill FR. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian cancer xenografts. Cancer Res 1993;53:2087-91.
    • (1993) Cancer Res , vol.53 , pp. 2087-2091
    • Davies, B.D.1    Brown, P.2    East, N.3    Crimmin, M.4    Balkwill, F.R.5
  • 96
    • 0029888124 scopus 로고    scopus 로고
    • The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice
    • Low JA, Johnson MD, Bone EA, Dickson RB. The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice. Clin Cancer Res 1996;2:1207-14.
    • (1996) Clin Cancer Res , vol.2 , pp. 1207-1214
    • Low, J.A.1    Johnson, M.D.2    Bone, E.A.3    Dickson, R.B.4
  • 97
    • 0031945505 scopus 로고    scopus 로고
    • Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian cancer
    • Giavazzi R, Garofalo A, Ferri C, Lucchini V, Bone EA, Chiari S, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian cancer. Clin Cancer Res 1998;4:985-92.
    • (1998) Clin Cancer Res , vol.4 , pp. 985-992
    • Giavazzi, R.1    Garofalo, A.2    Ferri, C.3    Lucchini, V.4    Bone, E.A.5    Chiari, S.6
  • 98
    • 0032952694 scopus 로고    scopus 로고
    • Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma
    • Prontera C, Mariani B, Rossi C, Poggi A, Rotilio D. Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma. Int J Cancer 1999;81:761-6.
    • (1999) Int J Cancer , vol.81 , pp. 761-766
    • Prontera, C.1    Mariani, B.2    Rossi, C.3    Poggi, A.4    Rotilio, D.5
  • 99
    • 0029847630 scopus 로고    scopus 로고
    • Phase 1 trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer
    • Wojtowicz-Praga S, Low J, Marshall J, Ness E, Dickson R, Barter J, et al. Phase 1 trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer. Invest New Drugs 1996;14:193-202.
    • (1996) Invest New Drugs , vol.14 , pp. 193-202
    • Wojtowicz-Praga, S.1    Low, J.2    Marshall, J.3    Ness, E.4    Dickson, R.5    Barter, J.6
  • 100
    • 0033032228 scopus 로고    scopus 로고
    • Phase I study of intrapleural batimastat (BB-94), a matrix metalloproteinase inhibitor, in the treatment of malignant pleural effusions
    • Macaulay VM, O'Byrne KJ, Saunders MP, Braybrooke JP, Long L, Gleeson F, et al. Phase I study of intrapleural batimastat (BB-94), a matrix metalloproteinase inhibitor, in the treatment of malignant pleural effusions. Clin Cancer Res 1999;5:513-20.
    • (1999) Clin Cancer Res , vol.5 , pp. 513-520
    • Macaulay, V.M.1    O'Byrne, K.J.2    Saunders, M.P.3    Braybrooke, J.P.4    Long, L.5    Gleeson, F.6
  • 101
    • 0031848158 scopus 로고    scopus 로고
    • Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascitis
    • Beattie G, Smyth J. Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascitis. Clin Cancer Res 1998;4:1899-902.
    • (1998) Clin Cancer Res , vol.4 , pp. 1899-1902
    • Beattie, G.1    Smyth, J.2
  • 102
    • 0031776982 scopus 로고    scopus 로고
    • Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer
    • Wojtowicz-Praga S, Torri J, Johnson M, Steen V, Marshall J, Ness E, et al. Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer. J Clin Oncol 1998;16:2150-6.
    • (1998) J Clin Oncol , vol.16 , pp. 2150-2156
    • Wojtowicz-Praga, S.1    Torri, J.2    Johnson, M.3    Steen, V.4    Marshall, J.5    Ness, E.6
  • 103
    • 0031882946 scopus 로고    scopus 로고
    • Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers
    • Millar A, Brown P, Moore J, Galloway WA, Cornish A, Lenehan T, et al. Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers. Br J Clin Pharmacol 1998;45:21-6.
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 21-26
    • Millar, A.1    Brown, P.2    Moore, J.3    Galloway, W.A.4    Cornish, A.5    Lenehan, T.6
  • 104
    • 0032934107 scopus 로고    scopus 로고
    • Marimastat in recurrent colorectal cancer: Exploratory evaluation of biological activity by measurement of carcinoembryonic antigen
    • Primrose J, Bleiberg H, Daniel F, Van Belle S, Mansi J, Seymour M, et al. Marimastat in recurrent colorectal cancer: Exploratory evaluation of biological activity by measurement of carcinoembryonic antigen. Br J Cancer 1999;79:509-14.
    • (1999) Br J Cancer , vol.79 , pp. 509-514
    • Primrose, J.1    Bleiberg, H.2    Daniel, F.3    Van Belle, S.4    Mansi, J.5    Seymour, M.6
  • 107
    • 0000632527 scopus 로고    scopus 로고
    • Phase IB study of concurrent administration of marimatat and gemcitabine in non-resectable pancreatic cancer
    • Carmichael J, Lederman J, Woll PGT, Russell R. Phase IB study of concurrent administration of marimatat and gemcitabine in non-resectable pancreatic cancer [abstract]. Proc Am Soc Clin Oncol 1998;17:232.
    • (1998) Proc Am Soc Clin Oncol , vol.17 , pp. 232
    • Carmichael, J.1    Lederman, J.2    Woll, P.G.T.3    Russell, R.4
  • 108
    • 0000100114 scopus 로고    scopus 로고
    • Schedules of 5-FU and the matrix metalloproteinase inhibitor marimastat (MAR): A phase 1 study
    • O'Reilly S, Mani S, Ratain M, Elza K, Brown S, Jonhson S, et al. Schedules of 5-FU and the matrix metalloproteinase inhibitor marimastat (MAR): A phase 1 study [abstract]. Proc Am Soc Clin Oncol 1998;17:217.
    • (1998) Proc Am Soc Clin Oncol , vol.17 , pp. 217
    • O'Reilly, S.1    Mani, S.2    Ratain, M.3    Elza, K.4    Brown, S.5    Jonhson, S.6
  • 109
    • 0000100112 scopus 로고    scopus 로고
    • A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapse ovarian cancer
    • Adams M, Thomas H. A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapse ovarian cancer [abstract]. Proc Am Soc Clin Oncol 1998;17:217.
    • (1998) Proc Am Soc Clin Oncol , vol.17 , pp. 217
    • Adams, M.1    Thomas, H.2
  • 110
    • 0000203704 scopus 로고    scopus 로고
    • Pilot pharmacokinetic study of marimastat (MAR) in combination with carboplatin (C)/Paclitaxel (T) in patients with metastatic or locally advanced inoperable non-small cell lung cance (NSCLC)
    • Anderson IC, Supko J, Eder J, Vasconcelles M, Shapiro G, Skarin A, et al. Pilot pharmacokinetic study of marimastat (MAR) in combination with carboplatin (C)/Paclitaxel (T) in patients with metastatic or locally advanced inoperable non-small cell lung cance (NSCLC) [abstract]. Proc Am Soc Clin Oncol 1999;18.
    • (1999) Proc Am Soc Clin Oncol , pp. 18
    • Anderson, I.C.1    Supko, J.2    Eder, J.3    Vasconcelles, M.4    Shapiro, G.5    Skarin, A.6
  • 111
    • 0032983844 scopus 로고    scopus 로고
    • Marimastat (BB2516): Current status and development
    • Steward WP. Marimastat (BB2516): Current status and development. Cancer Chemother Pharmacol 1999;43:S56-60.
    • (1999) Cancer Chemother Pharmacol , vol.43
    • Steward, W.P.1
  • 112
    • 0001937417 scopus 로고    scopus 로고
    • Phase I/+ pharmacokinetic evaluation of marimastat in patients (pts) with advanced prostate cancer (PC): Identification of the biological active dose
    • Eisenberger M, Sinibaldi V, Laufer M, Carducci M, Miller P, Boasberg F, et al. Phase I/+ pharmacokinetic evaluation of marimastat in patients (pts) with advanced prostate cancer (PC): Identification of the biological active dose [abstract]. Proc Am Soc Clin Oncol 2000;19:336.
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 336
    • Eisenberger, M.1    Sinibaldi, V.2    Laufer, M.3    Carducci, M.4    Miller, P.5    Boasberg, F.6
  • 114
    • 14444284598 scopus 로고    scopus 로고
    • Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biological active and tolerable dose for long term studies
    • Nemunaitis J, Poole C, Primrose J, Rosemurgy A, Malfetano J, Brown P, et al. Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biological active and tolerable dose for long term studies. Clin Cancer Res 1998;4:1101-9.
    • (1998) Clin Cancer Res , vol.4 , pp. 1101-1109
    • Nemunaitis, J.1    Poole, C.2    Primrose, J.3    Rosemurgy, A.4    Malfetano, J.5    Brown, P.6
  • 116
    • 0036499078 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus the matrix metalloprotcinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme
    • Groves MD, Puduvalli VK, Hess KR, Jaeckle KA, Peterson P, Alfred Yung WK, et al. Phase II trial of temozolomide plus the matrix metalloprotcinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme. J Clin Oncol 2002;25:1383-8.
    • (2002) J Clin Oncol , vol.25 , pp. 1383-1388
    • Groves, M.D.1    Puduvalli, V.K.2    Hess, K.R.3    Jaeckle, K.A.4    Peterson, P.5    Alfred Yung, W.K.6
  • 118
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • Bramhall SR, Rosemurgy A, Brown PD, Bowry C, Buckels JA. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial. J Clin Oncol 2001;19: 3445-7.
    • (2001) J Clin Oncol , vol.19 , pp. 3445-3447
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3    Bowry, C.4    Buckels, J.A.5
  • 119
    • 0000407860 scopus 로고    scopus 로고
    • A randomized double-blind placebo controlled study of marimastat in patients with inoperable gastric adenocarcinoma
    • Fielding J, Scholefield J, Stuart P, Hawkins R, McCulloch P, Maughan T, et al. A randomized double-blind placebo controlled study of marimastat in patients with inoperable gastric adenocarcinoma [abstract]. Proc Am Soc Clin Oncol 2000;929.
    • (2000) Proc Am Soc Clin Oncol , pp. 929
    • Fielding, J.1    Scholefield, J.2    Stuart, P.3    Hawkins, R.4    McCulloch, P.5    Maughan, T.6
  • 120
    • 0001419988 scopus 로고    scopus 로고
    • Bay 12-9566, a novel biphenyl matrix metalloproteinase inhibitor, demonstrated anti-invasive and anti-angiogenic properties
    • Hibner B, Card A, Flynn C, Casazza A, Taraboletti G, Rieppi M, et al. Bay 12-9566, a novel biphenyl matrix metalloproteinase inhibitor, demonstrated anti-invasive and anti-angiogenic properties [abstract]. Proc Am Assoc Can Res 1998;39:302.
    • (1998) Proc Am Assoc Can Res , vol.39 , pp. 302
    • Hibner, B.1    Card, A.2    Flynn, C.3    Casazza, A.4    Taraboletti, G.5    Rieppi, M.6
  • 121
    • 0001419989 scopus 로고    scopus 로고
    • Activity of the biphenyl matrix metalloproteinase inhibitor Bay 12-9566 in murine in vivo models
    • Bull C, Flynn C, Eberwein D, Casazza A, Carter C, Hibner B. Activity of the biphenyl matrix metalloproteinase inhibitor Bay 12-9566 in murine in vivo models [abstract]. Proc Am Assoc Can Res 1998;39:302.
    • (1998) Proc Am Assoc Can Res , vol.39 , pp. 302
    • Bull, C.1    Flynn, C.2    Eberwein, D.3    Casazza, A.4    Carter, C.5    Hibner, B.6
  • 122
    • 0000823543 scopus 로고    scopus 로고
    • Anti-metastatic activity of Bay 12-9566 in a human colon carcinoma HCT116 orthotopic model
    • Flynn C, Bull C, Eberwein D, Matheme C, Hibner B. Anti-metastatic activity of Bay 12-9566 in a human colon carcinoma HCT116 orthotopic model [abstract]. Proc Am Assoc Can Res 1998;39:301.
    • (1998) Proc Am Assoc Can Res , vol.39 , pp. 301
    • Flynn, C.1    Bull, C.2    Eberwein, D.3    Matheme, C.4    Hibner, B.5
  • 123
    • 0000823545 scopus 로고    scopus 로고
    • Inhibition of human breast cancer regrowth and pulmonary metastasis by Bay 12-9566 in athymie mice
    • Nozaki S, Sissons S, Casazza A, Sledge GWJ. Inhibition of human breast cancer regrowth and pulmonary metastasis by Bay 12-9566 in athymie mice [abstract]. Proc Am Assoc Can Res 1998;39.
    • (1998) Proc Am Assoc Can Res , pp. 39
    • Nozaki, S.1    Sissons, S.2    Casazza, A.3    Sledge, G.W.J.4
  • 124
    • 0003301987 scopus 로고    scopus 로고
    • Preclinical drug safety profile for the antimetastatic matrix metalloproteinase inhibitor agent Bay 12-9566
    • Clemens G, Detzer K, Bomhard E, von Keutz E. Preclinical drug safety profile for the antimetastatic matrix metalloproteinase inhibitor agent Bay 12-9566 [abstract]. Proc Nat Can Inst-Eur Org Res Treat Can 1998.
    • (1998) Proc Nat Can Inst-Eur Org Res Treat Can
    • Clemens, G.1    Detzer, K.2    Bomhard, E.3    Von Keutz, E.4
  • 125
    • 0001426054 scopus 로고    scopus 로고
    • [14C] Bay 12-9566: Assessment of enterohepatic cycling in male rats following intraduodenal administration
    • Perrino P, Ward D. [14C] Bay 12-9566: Assessment of enterohepatic cycling in male rats following intraduodenal administration [abstract]. Proc Am Assoc Can Res 1999;40:391.
    • (1999) Proc Am Assoc Can Res , vol.40 , pp. 391
    • Perrino, P.1    Ward, D.2
  • 126
    • 0000206088 scopus 로고    scopus 로고
    • Pharmacokinetics of Bay 12-9566 in guinea pigs following intravenous and oral administration
    • Chien D, Daly D, Brubaker W. Pharmacokinetics of Bay 12-9566 in guinea pigs following intravenous and oral administration [abstract]. Proc Am Assoc Can Res 1998;40:390.
    • (1998) Proc Am Assoc Can Res , vol.40 , pp. 390
    • Chien, D.1    Daly, D.2    Brubaker, W.3
  • 127
    • 0033986165 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies
    • Rowinsky E, Humphrey R, Hammond L, Aylesworth C, Smetzer L, Hidalgo M, et al. Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies. J Clin Oncol 2000; 18:178-86.
    • (2000) J Clin Oncol , vol.18 , pp. 178-186
    • Rowinsky, E.1    Humphrey, R.2    Hammond, L.3    Aylesworth, C.4    Smetzer, L.5    Hidalgo, M.6
  • 128
    • 0003318866 scopus 로고    scopus 로고
    • Clinical pharmacology of the metalloproteinase (MMP) and angiogenesis inhibitor Bayer 12-9566 in cancer patients
    • Goel R, Hirte H, Major P, Waterfield B, Holohan S, Bennett K, et al. Clinical pharmacology of the metalloproteinase (MMP) and angiogenesis inhibitor Bayer 12-9566 in cancer patients [abstract]. Proc Am Soc Clin Oncol 1999;18:160a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Goel, R.1    Hirte, H.2    Major, P.3    Waterfield, B.4    Holohan, S.5    Bennett, K.6
  • 131
    • 0000993867 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of the oral matrix metalloproteinase inhibitor Bay 12-9566 in combination with paclitaxel and carboplatin
    • Tolcher A, Rowinsky E, Rizzo J, Britten C, Siu L, Humphrey R, et al. A phase I and pharmacokinetic study of the oral matrix metalloproteinase inhibitor Bay 12-9566 in combination with paclitaxel and carboplatin [abstract]. Proc Am Soc Clin Oncol 1999;18:160.
    • (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 160
    • Tolcher, A.1    Rowinsky, E.2    Rizzo, J.3    Britten, C.4    Siu, L.5    Humphrey, R.6
  • 132
    • 0000550788 scopus 로고    scopus 로고
    • Pharmacokinetics of Bay 12-9566: Early results of a Canadian phase I dose escalation study in cancer patients
    • Hirte H, Goel R, Major P, Waterfield B, Holohan S, Bennett K, et al. Pharmacokinetics of Bay 12-9566: Early results of a Canadian phase I dose escalation study in cancer patients [abstract]. Proc Am Assoc Can Res 1998;39:364.
    • (1998) Proc Am Assoc Can Res , vol.39 , pp. 364
    • Hirte, H.1    Goel, R.2    Major, P.3    Waterfield, B.4    Holohan, S.5    Bennett, K.6
  • 133
    • 0003208131 scopus 로고    scopus 로고
    • Preclinical and clinical pharmacology of matrix metalloproteinase inhibitor (MMPIs)
    • Grochow L. Preclinical and clinical pharmacology of matrix metalloproteinase inhibitor (MMPIs) [abstract]. Proc Nat Can Inst-Eur Org Res Treat Cancer 1998.
    • (1998) Proc Nat Can Inst-Eur Org Res Treat Cancer
    • Grochow, L.1
  • 134
    • 0033986165 scopus 로고    scopus 로고
    • A phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor Bay 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies
    • Rowinsky E, Humphrey R, Hammond L, Aylesworth C, Smetzer L, Hidalgo M, et al. A phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor Bay 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies. J Clin Oncol 2000;18: 178-86.
    • (2000) J Clin Oncol , vol.18 , pp. 178-186
    • Rowinsky, E.1    Humphrey, R.2    Hammond, L.3    Aylesworth, C.4    Smetzer, L.5    Hidalgo, M.6
  • 135
    • 0000480156 scopus 로고    scopus 로고
    • A comparison between gemcitabine (GEM) and the matrix metalloproteinase (MMP) Inhibitor BAY12-9566 (9566) in patients (pts) with advanced pancreatic cancer
    • Moore MJ, Hamm P, Eisenberg P, Dagenais M, Hagan K, Fields A, et al. A comparison between gemcitabine (GEM) and the matrix metalloproteinase (MMP) Inhibitor BAY12-9566 (9566) in patients (pts) with advanced pancreatic cancer [abstract]. Proc Am Soc Clin Oncol 2000;19:240a.
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Moore, M.J.1    Hamm, P.2    Eisenberg, P.3    Dagenais, M.4    Hagan, K.5    Fields, A.6
  • 136
    • 0032837028 scopus 로고    scopus 로고
    • Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials
    • Shalinsky DR, Brekken J, Zou H, McDermott CD, Forsyth P, Edwards D, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci 1999;878:236-70.
    • (1999) Ann N Y Acad Sci , vol.878 , pp. 236-270
    • Shalinsky, D.R.1    Brekken, J.2    Zou, H.3    McDermott, C.D.4    Forsyth, P.5    Edwards, D.6
  • 137
    • 0030816454 scopus 로고    scopus 로고
    • Rodent pharmacokinetics and anti-tumor efficacy studies with a series of synthethic inhibitors of matrix metalloproteinases
    • Santos O, McDermott CD, Daniels R, Appelt K. Rodent pharmacokinetics and anti-tumor efficacy studies with a series of synthethic inhibitors of matrix metalloproteinases. Clin Exp Metastasis 1997;15:499-508.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 499-508
    • Santos, O.1    McDermott, C.D.2    Daniels, R.3    Appelt, K.4
  • 138
    • 0032449008 scopus 로고    scopus 로고
    • Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations
    • Shalinsky DR, Brekken J, Zou H, Kolis S, Wood A, Webber S, et al. Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations. Invest New Drugs 1998;16:303-13.
    • (1998) Invest New Drugs , vol.16 , pp. 303-313
    • Shalinsky, D.R.1    Brekken, J.2    Zou, H.3    Kolis, S.4    Wood, A.5    Webber, S.6
  • 139
    • 0032791421 scopus 로고    scopus 로고
    • Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: Single agent and combination chemotherapy studies
    • Shalinsky D, Brekken J, Zou H, Bloom L, McDermott CD, Zook S, et al. Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: Single agent and combination chemotherapy studies. Clin Cancer Res 1999;5:1905-17.
    • (1999) Clin Cancer Res , vol.5 , pp. 1905-1917
    • Shalinsky, D.1    Brekken, J.2    Zou, H.3    Bloom, L.4    McDermott, C.D.5    Zook, S.6
  • 140
    • 0032905581 scopus 로고    scopus 로고
    • Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340
    • Price A, Shi Q, Morris D, Wilcox ME, Brasher PM, Rewcastle NB, et al. Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340. Clin Cancer Res 1999;5:845-54.
    • (1999) Clin Cancer Res , vol.5 , pp. 845-854
    • Price, A.1    Shi, Q.2    Morris, D.3    Wilcox, M.E.4    Brasher, P.M.5    Rewcastle, N.B.6
  • 142
    • 0003320890 scopus 로고    scopus 로고
    • Phase 1 study of AG3340, a matrix metalloproteinase inhibitor in combination with mitoxantrone/prednisone in patients having advanced prostate cancer
    • Wilding G, Small E, Ripple G, Keller M, Yuen G, Collier M. Phase 1 study of AG3340, a matrix metalloproteinase inhibitor in combination with mitoxantrone/prednisone in patients having advanced prostate cancer [abstract]. Proceedings of Nat Can Inst-Eur Org Res Treat Can 1998.
    • (1998) Proceedings of Nat Can Inst-Eur Org Res Treat Can
    • Wilding, G.1    Small, E.2    Ripple, G.3    Keller, M.4    Yuen, G.5    Collier, M.6
  • 143
    • 0000603394 scopus 로고    scopus 로고
    • Phase I study of the matrix metalloproteinase inhibitor AG3340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors
    • D'Olimpio J, Hande K, Collier M, Michelson G, Paradiso N, Clendeninn N. Phase I study of the matrix metalloproteinase inhibitor AG3340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors [abstract]. Proc Am Soc Clin Oncol 1998;18:160.
    • (1998) Proc Am Soc Clin Oncol , vol.18 , pp. 160
    • D'Olimpio, J.1    Hande, K.2    Collier, M.3    Michelson, G.4    Paradiso, N.5    Clendeninn, N.6
  • 144
    • 0001185397 scopus 로고    scopus 로고
    • Phase II study of the matrix metalloprotease inhibitor prinomastat in patients with progressive breast cancer
    • Rugo HS, Budman D, Vogel C, et al. Phase II study of the matrix metalloprotease inhibitor prinomastat in patients with progressive breast cancer [abstract]. Proc ASCO 2001;20:187.
    • (2001) Proc ASCO , vol.20 , pp. 187
    • Rugo, H.S.1    Budman, D.2    Vogel, C.3
  • 145
    • 0001596022 scopus 로고    scopus 로고
    • Interim results of a phase III study of the matrix metalloprotease inhibitor prinomastat in patients having metastatic, hormone refractory prostate cancer (HRPC)
    • Ahmann FR, Saad F, Mercier R, et al. Interim results of a phase III study of the matrix metalloprotease inhibitor prinomastat in patients having metastatic, hormone refractory prostate cancer (HRPC) [abstract]. Proc ASCO 2001;20:692.
    • (2001) Proc ASCO , vol.20 , pp. 692
    • Ahmann, F.R.1    Saad, F.2    Mercier, R.3
  • 146
    • 0001185393 scopus 로고    scopus 로고
    • Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer (NSCLC)
    • Smylie M, Mercier R, Aboulafia D, et al. Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer (NSCLC) [abstract]. Proc ASCO 2001;20:1226.
    • (2001) Proc ASCO , vol.20 , pp. 1226
    • Smylie, M.1    Mercier, R.2    Aboulafia, D.3
  • 149
    • 0000909547 scopus 로고    scopus 로고
    • A phase I trial of BMS-275291: A novel, nonhydroxamate, sheddase-sparing matrix metalloproteinase inhibitor (MMPI) with no dose-limiting arthritis
    • Hurwitz H, Humphrey J, Williams K, et al. A phase I trial of BMS-275291: A novel, nonhydroxamate, sheddase-sparing matrix metalloproteinase inhibitor (MMPI) with no dose-limiting arthritis [abstract]. Proc ASCO 2001;20:387.
    • (2001) Proc ASCO , vol.20 , pp. 387
    • Hurwitz, H.1    Humphrey, J.2    Williams, K.3
  • 150
    • 0001159062 scopus 로고    scopus 로고
    • Safety and pharmacokinctics of BMS-275291, a novel matrix metalloproteinase inhibitor in healthy subjects
    • Daniels R, Gupta E, Kollia G, et al. Safety and pharmacokinctics of BMS-275291, a novel matrix metalloproteinase inhibitor in healthy subjects [abstract]. Proc ASCO 2001;20:395.
    • (2001) Proc ASCO , vol.20 , pp. 395
    • Daniels, R.1    Gupta, E.2    Kollia, G.3
  • 151
    • 0002917797 scopus 로고    scopus 로고
    • Pharmacokinetic (PK) Evaluation of BMS-275291, a matrix metalloproteinase (MMP) inhibitor, in cancer patients
    • Gupta E, Huang M, Mao Y, et al. Pharmacokinetic (PK) Evaluation of BMS-275291, a matrix metalloproteinase (MMP) inhibitor, in cancer patients [abstract]. Proc ASCO 2001;20:301.
    • (2001) Proc ASCO , vol.20 , pp. 301
    • Gupta, E.1    Huang, M.2    Mao, Y.3
  • 152
    • 0002593621 scopus 로고    scopus 로고
    • CGS 27023A, a potent and orally active matrix metalloprotease inhibitor with antitumor activity
    • Wood J, Muller M, Schnell M, Cozens R, O'Reilly T, Cox D. CGS 27023A, a potent and orally active matrix metalloprotease inhibitor with antitumor activity [abstract]. Proc Am Assoc Can Res 1998;39:83.
    • (1998) Proc Am Assoc Can Res , vol.39 , pp. 83
    • Wood, J.1    Muller, M.2    Schnell, M.3    Cozens, R.4    O'Reilly, T.5    Cox, D.6
  • 153
    • 0000089616 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitor (MMPI) CGS27023A inhibited extravasation of B16-F10 melanoma cells in the experimental metastatic model
    • Yoshida H, Kasaoka T, Watanabe T, Nishiyama H, Okada M, Toyoshima M, et al. Matrix metalloproteinase inhibitor (MMPI) CGS27023A inhibited extravasation of B16-F10 melanoma cells in the experimental metastatic model [abstract]. Proc Am Assoc Can Res 1999; 40:705.
    • (1999) Proc Am Assoc Can Res , vol.40 , pp. 705
    • Yoshida, H.1    Kasaoka, T.2    Watanabe, T.3    Nishiyama, H.4    Okada, M.5    Toyoshima, M.6
  • 154
    • 0034772722 scopus 로고    scopus 로고
    • Phase 1 and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (formerly CGS27023A), in patients with advanced solid cancer
    • Levitt NC, Eskens FA, O'Byme KJ, Propper DJ, Denis LJ, Owen SJ, et al. Phase 1 and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (formerly CGS27023A), in patients with advanced solid cancer. Clin Cancer Res 2001;7(7):1912-22.
    • (2001) Clin Cancer Res , vol.7 , Issue.7 , pp. 1912-1922
    • Levitt, N.C.1    Eskens, F.A.2    O'Byme, K.J.3    Propper, D.J.4    Denis, L.J.5    Owen, S.J.6
  • 155
    • 0032200444 scopus 로고    scopus 로고
    • Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms
    • Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res 1998;12: 12-26.
    • (1998) Adv Dent Res , vol.12 , pp. 12-26
    • Golub, L.M.1    Lee, H.M.2    Ryan, M.E.3    Giannobile, W.V.4    Payne, J.5    Sorsa, T.6
  • 156
    • 0032864675 scopus 로고    scopus 로고
    • MMP inhibition in prostate cancer
    • Lokeshwar BL. MMP inhibition in prostate cancer. Ann N Y Acad Sci 1999;878:271-89.
    • (1999) Ann N Y Acad Sci , vol.878 , pp. 271-289
    • Lokeshwar, B.L.1
  • 157
    • 0031281806 scopus 로고    scopus 로고
    • Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells
    • Fife RS, Rougraff BT, Proctor C, Sledge GWJ. Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells. J Lab Clin Med 1997;130: 530-4.
    • (1997) J Lab Clin Med , vol.130 , pp. 530-534
    • Fife, R.S.1    Rougraff, B.T.2    Proctor, C.3    Sledge, G.W.J.4
  • 159
    • 0031973365 scopus 로고    scopus 로고
    • In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: Relationship to bone and cartilage degradation
    • Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T. In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: Relationship to bone and cartilage degradation. Bone 1998;22:33-8.
    • (1998) Bone , vol.22 , pp. 33-38
    • Greenwald, R.A.1    Golub, L.M.2    Ramamurthy, N.S.3    Chowdhury, M.4    Moak, S.A.5    Sorsa, T.6
  • 160
    • 0029688549 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibition in periodontal treatment
    • Ryan ME, Ramamurthy S, Golub LM. Matrix metalloproteinases and their inhibition in periodontal treatment. Curr Opin Periodontol 1996;3:85-96.
    • (1996) Curr Opin Periodontol , vol.3 , pp. 85-96
    • Ryan, M.E.1    Ramamurthy, S.2    Golub, L.M.3
  • 161
    • 0021677785 scopus 로고
    • Tetracyclines inhibit tissue collagenase activity: A new mechanism in the treatment of periodontal disease
    • Golub LM, Ramamurthy NS, McNamara TF, Gomes BC, Wolff MS, Casino A, et al. Tetracyclines inhibit tissue collagenase activity: A new mechanism in the treatment of periodontal disease. J Periodont Res 1984;19:651-5.
    • (1984) J Periodont Res , vol.19 , pp. 651-655
    • Golub, L.M.1    Ramamurthy, N.S.2    McNamara, T.F.3    Gomes, B.C.4    Wolff, M.S.5    Casino, A.6
  • 163
    • 0344483895 scopus 로고    scopus 로고
    • Specificity of inhibition of matrix metalloproteinase activity by doxycycline
    • Smith GN, Mickler EA, Hasty KA, Brandt KD. Specificity of inhibition of matrix metalloproteinase activity by doxycycline. Arthritis Rheum 1999;42:1140-6.
    • (1999) Arthritis Rheum , vol.42 , pp. 1140-1146
    • Smith, G.N.1    Mickler, E.A.2    Hasty, K.A.3    Brandt, K.D.4
  • 164
    • 0029257434 scopus 로고
    • Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells
    • Fife R, Sledge GWJ. Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells. J Lab Clin Med 1995;125:407-11.
    • (1995) J Lab Clin Med , vol.125 , pp. 407-411
    • Fife, R.1    Sledge, G.W.J.2
  • 165
    • 0032523857 scopus 로고    scopus 로고
    • Effects of doxycycline on human prostate cancer cells in vitro
    • Fife R, Sledge GWJ, Roth B, Proctor C. Effects of doxycycline on human prostate cancer cells in vitro. Cancer Lett 1998;127:37-41.
    • (1998) Cancer Lett , vol.127 , pp. 37-41
    • Fife, R.1    Sledge, G.W.J.2    Roth, B.3    Proctor, C.4
  • 166
    • 0031545846 scopus 로고    scopus 로고
    • Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells
    • Duivenvoorden WC, Hirte H, Singh G. Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells. Invasion Metastasis 1997;17:312-22.
    • (1997) Invasion Metastasis , vol.17 , pp. 312-322
    • Duivenvoorden, W.C.1    Hirte, H.2    Singh, G.3
  • 167
    • 0028889359 scopus 로고
    • Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice
    • Sledge GWJ, Qulali M, Bone EA, Fife R. Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice. J Natl Can Inst 1995;87: 1546-50.
    • (1995) J Natl Can Inst , vol.87 , pp. 1546-1550
    • Sledge, G.W.J.1    Qulali, M.2    Bone, E.A.3    Fife, R.4
  • 169
    • 0032837305 scopus 로고    scopus 로고
    • CMT-3, a chemically modified tetracycline, inhibits bony metastases and delays the development of paraplegia in a rat model of prostate cancer
    • Selzer MG, Zhu B, Block NL, Lokeshwar BL. CMT-3, a chemically modified tetracycline, inhibits bony metastases and delays the development of paraplegia in a rat model of prostate cancer. Ann N Y Acad Sci 1999;878:678-82.
    • (1999) Ann N Y Acad Sci , vol.878 , pp. 678-682
    • Selzer, M.G.1    Zhu, B.2    Block, N.L.3    Lokeshwar, B.L.4
  • 170
    • 0000433329 scopus 로고    scopus 로고
    • Protracted daily treatment with Col-3, and oral tetracycline analog, matrix metalloproteinase (MMP) inhibitor, is feasible: A phase I pharmacokinetic and biological study
    • Rowinsky E, Eckhardt S, Rizzo J, Hammond L, Campbell E, Felton S, et al. Protracted daily treatment with Col-3, and oral tetracycline analog, matrix metalloproteinase (MMP) inhibitor, is feasible: A phase I pharmacokinetic and biological study. Proc Am Soc Clin Oncol 2000; 19:180.
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 180
    • Rowinsky, E.1    Eckhardt, S.2    Rizzo, J.3    Hammond, L.4    Campbell, E.5    Felton, S.6
  • 171
    • 0035863463 scopus 로고    scopus 로고
    • A phase I clinical trial of oral COL-3, a matrix metalloproteinase inhibitor, in patients with refractory metastatic cancer
    • Rudek MA, Figg WD, Dyer V, et al. A phase I clinical trial of oral COL-3, a matrix metalloproteinase inhibitor, in patients with refractory metastatic cancer. J Clin Oncol 2001;19(2): 584-92.
    • (2001) J Clin Oncol , vol.19 , Issue.2 , pp. 584-592
    • Rudek, M.A.1    Figg, W.D.2    Dyer, V.3
  • 172
    • 0035056156 scopus 로고    scopus 로고
    • Reversible sideroblastic anemia associated with the tetracycline analogue COL-3
    • Rudek MA, Home M, Figg WD, Dahut W, Dyer V, Pluda JM, et al. Reversible sideroblastic anemia associated with the tetracycline analogue COL-3. Am J Hematol 2001;67(1):51-3.
    • (2001) Am J Hematol , vol.67 , Issue.1 , pp. 51-53
    • Rudek, M.A.1    Home, M.2    Figg, W.D.3    Dahut, W.4    Dyer, V.5    Pluda, J.M.6
  • 174
    • 0000294326 scopus 로고    scopus 로고
    • Pharmacodynamic studies of Col-3, a novel matrix metalloproteinase inhibitor, in patients with advanced cancer
    • Munoz-Mateu M, de'Grafenried L, Eckhardt SG, et al. Pharmacodynamic studies of Col-3, a novel matrix metalloproteinase inhibitor, in patients with advanced cancer [abstract]. Proc Am Soc Clin Oncol 2001;20:302.
    • (2001) Proc Am Soc Clin Oncol , vol.20 , pp. 302
    • Munoz-Mateu, M.1    De'Grafenried, L.2    Eckhardt, S.G.3
  • 175
    • 4243732760 scopus 로고    scopus 로고
    • Cancer Trials. National Cancer Institute. 2001. http://www.cancer.gov/clinical.htm.
    • (2001) Cancer Trials
  • 176
    • 3543125222 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic (PK) study of COL-3, an oral tetracycline analog and selective matrix metalloproteinase (MMP) inhibitor
    • Rowinsky EK, Eckhardt SG, Rizzo J, et al. A phase I and pharmacokinetic (PK) study of COL-3, an oral tetracycline analog and selective matrix metalloproteinase (MMP) inhibitor [abstract]. Clin Cancer Res 2000;6:292a.
    • (2000) Clin Cancer Res , vol.6
    • Rowinsky, E.K.1    Eckhardt, S.G.2    Rizzo, J.3
  • 177
    • 0036137547 scopus 로고    scopus 로고
    • Angiogenesis inhibits COL-3 in the treatment of AIDS-related Kaposi's sarcoma: A phase I AIDS Malignancy Consortium study
    • Cianfrocca M, Cooley TP, Lee JY, et al. Angiogenesis inhibits COL-3 in the treatment of AIDS-related Kaposi's sarcoma: A phase I AIDS Malignancy Consortium study. J Clin Oncol 2002; 20(1):153-9.
    • (2002) J Clin Oncol , vol.20 , Issue.1 , pp. 153-159
    • Cianfrocca, M.1    Cooley, T.P.2    Lee, J.Y.3
  • 178
    • 10544228130 scopus 로고    scopus 로고
    • Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastasis
    • Delmas PD. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastasis. N Engl J Med 1996;335:1785-91.
    • (1996) N Engl J Med , vol.335 , pp. 1785-1791
    • Delmas, P.D.1
  • 179
    • 10544228130 scopus 로고    scopus 로고
    • Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastasis
    • Hortobagyi GN. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastasis. N Engl J Med 1996;335:1785-91.
    • (1996) N Engl J Med , vol.335 , pp. 1785-1791
    • Hortobagyi, G.N.1
  • 180
    • 0029884643 scopus 로고    scopus 로고
    • Biphosphonates: Mechanism of action
    • Rodan GA, Fleisch HA. Biphosphonates: Mechanism of action. J Clin Invest 1996;97:2692-6.
    • (1996) J Clin Invest , vol.97 , pp. 2692-2696
    • Rodan, G.A.1    Fleisch, H.A.2
  • 181
    • 0032428103 scopus 로고    scopus 로고
    • Alendronate blocks metalloproteinase secretion and bone collagen I release by PC-3 ML cells in SCID mice
    • Stearns ME, Wang M. Alendronate blocks metalloproteinase secretion and bone collagen I release by PC-3 ML cells in SCID mice. Clin Exp Metastasis 1998;16:693-702.
    • (1998) Clin Exp Metastasis , vol.16 , pp. 693-702
    • Stearns, M.E.1    Wang, M.2
  • 182
    • 0031803029 scopus 로고    scopus 로고
    • Alendronate blocks TGF-betal stimulated collagen 1 degradation by human prostate PC-3 ML cells
    • Stearns ME. Alendronate blocks TGF-betal stimulated collagen 1 degradation by human prostate PC-3 ML cells. Clin Exp Metastasis 1998;16:332-9.
    • (1998) Clin Exp Metastasis , vol.16 , pp. 332-339
    • Stearns, M.E.1
  • 185
    • 0033559212 scopus 로고    scopus 로고
    • Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models
    • Lozonschi L, Sunamura M, Kobari M, Egawa S, Ding L, Matsuno S. Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models. Cancer Res 1999;59:1252-8.
    • (1999) Cancer Res , vol.59 , pp. 1252-1258
    • Lozonschi, L.1    Sunamura, M.2    Kobari, M.3    Egawa, S.4    Ding, L.5    Matsuno, S.6
  • 186
    • 0033559205 scopus 로고    scopus 로고
    • Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor
    • Maekawa R, Maki H, Yoshida H, Hojo K, Tanaka H, Wada T, et al. Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor. Cancer Res 1999;59:1231-5.
    • (1999) Cancer Res , vol.59 , pp. 1231-1235
    • Maekawa, R.1    Maki, H.2    Yoshida, H.3    Hojo, K.4    Tanaka, H.5    Wada, T.6
  • 187
    • 0033006940 scopus 로고    scopus 로고
    • Preventive effect of matrix metalloproteinase inhibitor, R-94138, in combination with mitomycin C or cisplatin on peritoneal dissemination of human gastric cancer cell line TMK-1 in nude mice
    • Igarashi N, Kubota T, Otani Y, Matsuzaki SW, Watanabe M, Teramoto T, et al. Preventive effect of matrix metalloproteinase inhibitor, R-94138, in combination with mitomycin C or cisplatin on peritoneal dissemination of human gastric cancer cell line TMK-1 in nude mice. Jpn J Cancer Res 1999;90:116-21.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 116-121
    • Igarashi, N.1    Kubota, T.2    Otani, Y.3    Matsuzaki, S.W.4    Watanabe, M.5    Teramoto, T.6
  • 188
    • 14444272508 scopus 로고    scopus 로고
    • Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives
    • Tamura Y, Watanabe F, Nakatani T, Yasui K, Fuji M, Komurasaki T, et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J Med Chem 1998;41:640-9.
    • (1998) J Med Chem , vol.41 , pp. 640-649
    • Tamura, Y.1    Watanabe, F.2    Nakatani, T.3    Yasui, K.4    Fuji, M.5    Komurasaki, T.6
  • 189
    • 0032910336 scopus 로고    scopus 로고
    • Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor
    • Kido A, Tsutsumi M, Iki K, Motoyama M, Takahama M, Tsujiuchi T, et al. Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor. Jpn J Cancer Res 1999;90:333-41.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 333-341
    • Kido, A.1    Tsutsumi, M.2    Iki, K.3    Motoyama, M.4    Takahama, M.5    Tsujiuchi, T.6
  • 194
    • 0032170034 scopus 로고    scopus 로고
    • Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line
    • Lombard MA, Wallace TL, Kubicek MF, Petzold GL, Mitchell MA, Hendges SK, et al. Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line. Cancer Res 1998;58:4001-7.
    • (1998) Cancer Res , vol.58 , pp. 4001-4007
    • Lombard, M.A.1    Wallace, T.L.2    Kubicek, M.F.3    Petzold, G.L.4    Mitchell, M.A.5    Hendges, S.K.6
  • 195
    • 0029891449 scopus 로고    scopus 로고
    • Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures
    • Williams LM, Gibbons DL, Gearing A, Maini RN, Feldmann M, Brennan FM. Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures. J Clin Invest 1996;97:2833-41.
    • (1996) J Clin Invest , vol.97 , pp. 2833-2841
    • Williams, L.M.1    Gibbons, D.L.2    Gearing, A.3    Maini, R.N.4    Feldmann, M.5    Brennan, F.M.6
  • 196


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.