IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice: IL-10 stimulation of TIMP-1 and inhibition of MMP-2/MMP-9 expression

Invasion and Metastasis

Volumn 17, Issue 2, 1998, Pages 62-74

  Stearns, M E ^a   Fudge, K ^a   Garcia, F ^a   Wang, M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

IL 10; MMP 2; MMP 9; PC 3 ML; SCID mice; TIMP 1

Indexed keywords

GELATINASE A; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; RECEPTOR ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW METASTASIS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN INDUCTION; SCID MOUSE;

ANIMALS; BONE NEOPLASMS; COLLAGENASES; GELATINASES; HUMANS; INTERLEUKIN-10; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MICE; MICE, SCID; NEOPLASM PROTEINS; PROSTATIC NEOPLASMS; SURVIVAL ANALYSIS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TUMOR CELLS, CULTURED;

EID: 0344936742     PISSN: 02511789     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Denhardt DT, Feng B, Dylan RE, Cocuzzi ET, Malyankar UM: Tissue inhibitor of metalloproteinases (TIMP, aka EPA): Structure, control of expression and biological functions. Pharmacol Ther 1993;59: 329-341.
2. Campbell CE, Flenniken AM, Skup D, Williams BRG: Identification of a serum- and phorbol-ester-responsive element in the murine tissue inhibitor of metalloproteinase gene. J Biol Chem 1991;266:7199-7206.
3. Edwards DR, Rocheleau H, Sharma RR, Willis AJ, Cowie A, Hassell JA, Heath JK: Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription. Biochim Biophys Acta 1992; 171:41-55.
4. MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson N1: Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. J Biol Chem 1990;265:17238-17245.
5. Khokha R, Waterhouse P, Yagel S, Lala K, Overall CM, Norton G, Denhardt DT: Antisense RNA-induced reduction in murine TIMP confers oncogenicity on Swiss 3T3 cells. Science 1989;243:947-950.
6. Lacraz S, Nicod L, Rochemonteix BG, Baumberger C, Dayer JM, Welgus HGJ: Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4. Clin Invest 1993;90:382-388.
7. Lacraz S, Nicod LP, Chicheportiche R, Welgus HG, Dayer JM: IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J Clin Invest 1995;96:2304-2310.
8. Pontera C, Crescenzi G, Rotilio D: Inhibition of interleukin-4 of stromelysin expression in human skin fibroblasts: Role of PKC collagenase and 92-kDa type IV collagenase/gelatinase production by human monocytes. J Biol Chem 1996;267: 515-519.
9. Stearns M, Wang M, Stearns ME: Cytokine (IL-10, IL-6) induction of tissue inhibitor of metalloproteinase 1 in primary human prostate tumor cell lines. Oncol Res 1995;7:173-181.
10. Wang M, Stearns ME: Isolation and characterization of PC-3 human prostatic tumor sublines which preferentially metastasize to select organs in s.c.i.d. mice. Differentiation 1991;48:115-125.
11. Wang QF, Khoury RH, Smith PC, McConnell DS, Padmanahban V, Midgley AR Jr, Schneyer AL, Crowley WF Jr, Sluss PM: A two-site monoclonal antibody immunoradiometric assay form human follistatin: Secretion by a human ovarian teratocarcinoma-derived cell line (PA-1). J Clin Endocrinol Metab 1996;8:1434-1441.
12. LaRocca RV, Danesi R, Cooper MR, Jamis-Dow CA, Ewing MW, Linehan WM, Myers CE: Effect of suramin on human prostate cancer cells in vitro. J Urol 1991;145:393-398.
13. Stearns ME, Wang M: Immunoassays of the metalloproteinase (MMP-2, 9) and tissue inhibitor of metalloproteinase (TIMP-1, 2) levels in noninvasive and metastatic PC-3 clones. Effects of Taxol. Oncol Res 1996;6:195-202.
14. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem 1976;72: 248-254.
15. Huang S, Xie K, Bucana CD, Ullrich SE, Bar-Eli M: Interleukin α 10 suppresses tumor growth and metastasis of human melanoma cells: Potential inhibition of angiogenesis. Clin Cancer Res 1996;2:1969-1979.
16. Kundu N, Beaty TL, Jackson MJ, Fulton AM: Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer. J Natl Cancer Inst 1996;88:536-541.
17. Richter G, Kruger-Krasagakes S, Hein G, Huls C, Schmitt E, Diamantstein T, Blankenstein T: Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration. Cancer Res 1993;53:4134-4137.