Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer

Investigational New Drugs

Volumn 14, Issue 2, 1996, Pages 193-202

  Wojtowicz Praga, Slawomir ^a,d   Low, Jennifer ^b   Marshall, John ^a   Ness, Elizabeth ^a   Dickson, Robert ^b   Barter, James ^b   Sale, Mark ^b   McCann, Peter ^c   Moore, Jeff ^c   Cole, Alice ^c   Hawkins, Michael J ^b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c British Biotech Inc   (United States)

^d Theradex   (United States)

Author keywords

Clinical trial; Human; Intraperitoneal administration; Malignancies; Matrix metalloproteinase inhibitors

Indexed keywords

BATIMASTAT; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; ZINC;

ABDOMINAL PAIN; ADULT; ADVANCED CANCER; AGED; ANGIOGENESIS; AREA UNDER THE CURVE; ARTICLE; ASCITES; BASEMENT MEMBRANE; BRADYCARDIA; BREAST CANCER; CANCER INVASION; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONSTIPATION; DIARRHEA; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; EXTRACELLULAR MATRIX; FATIGUE; FEMALE; FEVER; HUMAN; HYPOTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY CANCER; LUNG CANCER; MALE; NAUSEA; OVARY TUMOR; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; UTERINE CERVIX CANCER; VOMITING;

EID: 0029847630     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00210790     Document Type: Article

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