메뉴 건너뛰기




Volumn 107, Issue 1, 1999, Pages 174-180

Clinical studies with matrix metalloproteinase inhibitors

Author keywords

Cancer therapy; Clinical trials; Matrix metalloproteinase; Protease inhibitors

Indexed keywords

BAY 12 9568; CGS 27023A; CIPEMASTAT; GEMCITABINE; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; PRINOMASTAT; UNCLASSIFIED DRUG;

EID: 0033034041     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1999.tb01541.x     Document Type: Review
Times cited : (129)

References (41)
  • 2
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • 2. Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997;89:1260-70.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 3
    • 0027683226 scopus 로고
    • Structural biochemistrv and activation of matrix metalloproteinases
    • 3. Kleiner DE, Stetler-Stevenson WG. Structural biochemistrv and activation of matrix metalloproteinases. Curr Op Cell Biol 1993;5:891-7.
    • (1993) Curr Op Cell Biol , vol.5 , pp. 891-897
    • Kleiner, D.E.1    Stetler-Stevenson, W.G.2
  • 5
    • 0030717692 scopus 로고    scopus 로고
    • Tissue inhibitors of metallo-proteinases - Structure, regulation and biological functions
    • 5. Gomez DE, Alonso DF, Yoshiji H, Thorgeirsson UP. Tissue inhibitors of metallo-proteinases - structure, regulation and biological functions. Eur J Cell Biol 1997;74:111-22.
    • (1997) Eur J Cell Biol , vol.74 , pp. 111-122
    • Gomez, D.E.1    Alonso, D.F.2    Yoshiji, H.3    Thorgeirsson, U.P.4
  • 6
    • 0030825453 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors in the treatment of cancer
    • 6. Brown PD. Matrix metalloproteinase inhibitors in the treatment of cancer. Medical Oncology 1997;14:1-10.
    • (1997) Medical Oncology , vol.14 , pp. 1-10
    • Brown, P.D.1
  • 8
    • 0031882946 scopus 로고    scopus 로고
    • Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor niarimastat in healthy male volunteers
    • 8. Millar AW, Brown PD, Moore J, Galloway WA, Cornish AG, Lenehan TJ, Lynch KP. Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor niarimastat in healthy male volunteers. Br J Clin Pharm 1998;45:21-6.
    • (1998) Br J Clin Pharm , vol.45 , pp. 21-26
    • Millar, A.W.1    Brown, P.D.2    Moore, J.3    Galloway, W.A.4    Cornish, A.G.5    Lenehan, T.J.6    Lynch, K.P.7
  • 9
    • 0028838862 scopus 로고
    • Structure determination and analysis of human neutrophil collagenase complexed with a hydoxamate inhibitor
    • 9. Grams F, Crimmin M, Hinnes L, Huxley P, Pieper M, Tschesche H, Bode W. Structure determination and analysis of human neutrophil collagenase complexed with a hydoxamate inhibitor. Biochemistry 1995;34:14012-20.
    • (1995) Biochemistry , vol.34 , pp. 14012-14020
    • Grams, F.1    Crimmin, M.2    Hinnes, L.3    Huxley, P.4    Pieper, M.5    Tschesche, H.6    Bode, W.7
  • 10
    • 0023245356 scopus 로고
    • A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity
    • 10. Golub LM, McNamara TF, D'Angelo G, Greenwald RA, Ramamurthy NS. A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J Dental Res 1987;66:1310-4.
    • (1987) J Dental Res , vol.66 , pp. 1310-1314
    • Golub, L.M.1    McNamara, T.F.2    D'Angelo, G.3    Greenwald, R.A.4    Ramamurthy, N.S.5
  • 11
    • 8244260609 scopus 로고    scopus 로고
    • Conversion of a highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor
    • 11. An Z, Wang X, Willmott N, Chander SK, Tickle S, Docherty AJP et al. Conversion of a highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor. Clin Exp Met 1997;15:184-95.
    • (1997) Clin Exp Met , vol.15 , pp. 184-195
    • An, Z.1    Wang, X.2    Willmott, N.3    Chander, S.K.4    Tickle, S.5    Docherty, A.J.P.6
  • 12
    • 0001015980 scopus 로고    scopus 로고
    • A phase I study of the matrix metalloproteinase (MMP) inhibitor AG3340 given in single doses to healthy volunteers
    • abstract #1491,221
    • 12. Collier MA, Yuen GJ, Bansal SK, Kolis S, Chew TG, Appelt K, Clendennin NJ. A phase I study of the matrix metalloproteinase (MMP) inhibitor AG3340 given in single doses to healthy volunteers. Proc Am Assoc Cancer Res 1997; 38: abstract #1491,221.
    • (1997) Proc Am Assoc Cancer Res , vol.38
    • Collier, M.A.1    Yuen, G.J.2    Bansal, S.K.3    Kolis, S.4    Chew, T.G.5    Appelt, K.6    Clendennin, N.J.7
  • 13
    • 0001719456 scopus 로고    scopus 로고
    • Comparative pharmacokinetics (PK) of BAY 12-9566, a metalloproteinase (MMP) inhibitor, in healthy volunteers and cancer patients
    • abstract #3547,521
    • 13. Shah A, Sundaresan P, Humphrey R, Heller AH. Comparative pharmacokinetics (PK) of BAY 12-9566, a metalloproteinase (MMP) inhibitor, in healthy volunteers and cancer patients. Proc Am Assoc Cancer Res 1998; 39: abstract #3547,521.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Shah, A.1    Sundaresan, P.2    Humphrey, R.3    Heller, A.H.4
  • 14
    • 0030728087 scopus 로고    scopus 로고
    • Cartilage protective agent (CPA) Ro 32-3555, a new matrix metalloproteinase inhibitor for the treatment of rheumatoid arthritis
    • 14. Wood ND, Aitken M, Durston S, Harris S, McClelland GR, Sharp S. Cartilage protective agent (CPA) Ro 32-3555, a new matrix metalloproteinase inhibitor for the treatment of rheumatoid arthritis. Agents and Actions 1998;49:49-55.
    • (1998) Agents and Actions , vol.49 , pp. 49-55
    • Wood, N.D.1    Aitken, M.2    Durston, S.3    Harris, S.4    McClelland, G.R.5    Sharp, S.6
  • 15
    • 0023919232 scopus 로고
    • Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells
    • 15. Reich R, Thompson EW, Iwamoto Y, Martin GR, Deason JR, Fuller GC, Miskin R. Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells. Cancer Res 1988;48:3307-12.
    • (1988) Cancer Res , vol.48 , pp. 3307-3312
    • Reich, R.1    Thompson, E.W.2    Iwamoto, Y.3    Martin, G.R.4    Deason, J.R.5    Fuller, G.C.6    Miskin, R.7
  • 16
    • 0029934985 scopus 로고    scopus 로고
    • Control of lymphatic and hematogenous metastases of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94)
    • 16. Eccles SA, Box GM, Court WJ, Bone EA, Thomas W, Brown PD. Control of lymphatic and hematogenous metastases of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94). Cancer Res 1996;56:2815-22.
    • (1996) Cancer Res , vol.56 , pp. 2815-2822
    • Eccles, S.A.1    Box, G.M.2    Court, W.J.3    Bone, E.A.4    Thomas, W.5    Brown, P.D.6
  • 17
    • 0027994031 scopus 로고
    • Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumour growth and spread in a patient-like orthotopic model in nude mice
    • 17. Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumour growth and spread in a patient-like orthotopic model in nude mice. Cancer Res 1994;54:4726-8.
    • (1994) Cancer Res , vol.54 , pp. 4726-4728
    • Wang, X.1    Fu, X.2    Brown, P.D.3    Crimmin, M.J.4    Hoffman, R.M.5
  • 18
    • 0028889359 scopus 로고
    • Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice
    • 18. Sledge GW, Qulali M, Goulet R, Bone EA, Fife R. Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice. J Natl Cancer Res 1995;87:1546-50.
    • (1995) J Natl Cancer Res , vol.87 , pp. 1546-1550
    • Sledge, G.W.1    Qulali, M.2    Goulet, R.3    Bone, E.A.4    Fife, R.5
  • 19
    • 0001419991 scopus 로고    scopus 로고
    • Marked inhibition of tumour growth in a malignant glioma tumour model by the novel synthetic matrix metalloproteinase inhibitor AG3340
    • abstract #2058,301
    • 19. Price A, Raja JB, Rewcastle NB, Yong VW, Zhong QS, Brasher P et al. Marked inhibition of tumour growth in a malignant glioma tumour model by the novel synthetic matrix metalloproteinase inhibitor AG3340. Proc Am Assoc Cancer Res 1998; 39: abstract #2058,301.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Price, A.1    Raja, J.B.2    Rewcastle, N.B.3    Yong, V.W.4    Zhong, Q.S.5    Brasher, P.6
  • 20
    • 0000435182 scopus 로고    scopus 로고
    • Marked inhibition of the proliferation of human adenocarcinoma colon tumours in vivo by orally administered AG3340, a novel matrix metalloproteinase (MMP) inhibitor
    • abstract #2059,302
    • 20. Shalinsky DR, Brekken J, Robinson SR, Varki NV, Daniels R, Bender S et al. Marked inhibition of the proliferation of human adenocarcinoma colon tumours in vivo by orally administered AG3340, a novel matrix metalloproteinase (MMP) inhibitor. Proc Am Assoc Cancer Res 1998; 39: abstract #2059,302.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Shalinsky, D.R.1    Brekken, J.2    Robinson, S.R.3    Varki, N.V.4    Daniels, R.5    Bender, S.6
  • 21
    • 0030816454 scopus 로고    scopus 로고
    • Rodent pharmacokinetic and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases
    • 21. Santos O, McDermott CD, Daniels RG, Appelt K. Rodent pharmacokinetic and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases. Clin Exp Metastasis 1997;15:499-508.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 499-508
    • Santos, O.1    McDermott, C.D.2    Daniels, R.G.3    Appelt, K.4
  • 22
    • 0001419990 scopus 로고    scopus 로고
    • AG3340, a novel matrix metalloproteinase (MMP) inhibitor, decreases growth and metastases of orthotopic human lung cancer in a nude rat preclinical model system
    • abstract #2061,302
    • 22. Johnston MR, Mullen JBM, Pagura M, Appelt K, Shalinsky DR. AG3340, a novel matrix metalloproteinase (MMP) inhibitor, decreases growth and metastases of orthotopic human lung cancer in a nude rat preclinical model system. Proc Am Assoc Cancer Res 1998; 39: abstract #2061,302.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Johnston, M.R.1    Mullen, J.B.M.2    Pagura, M.3    Appelt, K.4    Shalinsky, D.R.5
  • 23
    • 0001419989 scopus 로고    scopus 로고
    • Activity of the biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in murine in vivo models
    • abstract #2062,302
    • 23. Bull C, Flynn C, Eberwein D, Casazza AM, Carter CA, Hibner B. Activity of the biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in murine in vivo models. Proc Am Assoc Cancer Res 1998; 39: abstract #2062,302.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Bull, C.1    Flynn, C.2    Eberwein, D.3    Casazza, A.M.4    Carter, C.A.5    Hibner, B.6
  • 25
    • 0001419988 scopus 로고    scopus 로고
    • BAY 12-9566, a novel biphenyl matrix metalloproteinase inhibitor, demonstrates anti-invasive and anti-angiogenic properties
    • abstract #2063,302
    • 25. Hibner B, Card A, Flynn C, Casazza AM, Taraboletti G, Rieppi M, Giavazzi R. BAY 12-9566, a novel biphenyl matrix metalloproteinase inhibitor, demonstrates anti-invasive and anti-angiogenic properties. Proc Am Assoc Cancer Res 1998; 39: abstract #2063,302.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Hibner, B.1    Card, A.2    Flynn, C.3    Casazza, A.M.4    Taraboletti, G.5    Rieppi, M.6    Giavazzi, R.7
  • 26
    • 0030042145 scopus 로고    scopus 로고
    • Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma
    • 26. Anderson IC, Shipp MA, Docherty AJP, Teicher BA. Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma. Cancer Res 1996;56:715-8.
    • (1996) Cancer Res , vol.56 , pp. 715-718
    • Anderson, I.C.1    Shipp, M.A.2    Docherty, A.J.P.3    Teicher, B.A.4
  • 27
    • 0001419987 scopus 로고    scopus 로고
    • Pharmacokinetics and efficacy of a novel matrix metalloproteinase inhibitor, AG3340, in single agent and combination therapy against B16-F10 melanoma tumours developing in the lung after Ivtail vein implantation in C57BL/6 mice
    • abstract #2060,302
    • 27. Neri A, Goggin B, Kolis S, Brekken J, Khelemskaya N, Gabriel L et al. Pharmacokinetics and efficacy of a novel matrix metalloproteinase inhibitor, AG3340, in single agent and combination therapy against B16-F10 melanoma tumours developing in the lung after Ivtail vein implantation in C57BL/6 mice. Proc Am Assoc Cancer Res 1998; 39: abstract #2060,302.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Neri, A.1    Goggin, B.2    Kolis, S.3    Brekken, J.4    Khelemskaya, N.5    Gabriel, L.6
  • 28
    • 0031945505 scopus 로고    scopus 로고
    • Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the anti-tumour activity of cisplatin in ovarian carcinoma xenografts
    • 28. Giavazzi R, Garofalo A, Lucchini V, Bone EA, Chiari S, Brown PD, Nicoletti MI, Taraboletti G. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the anti-tumour activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res 1998;4:985-92.
    • (1998) Clin Cancer Res , vol.4 , pp. 985-992
    • Giavazzi, R.1    Garofalo, A.2    Lucchini, V.3    Bone, E.A.4    Chiari, S.5    Brown, P.D.6    Nicoletti, M.I.7    Taraboletti, G.8
  • 29
    • 0343965762 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for resected Dukes' C colorectal cancer: Seven-year outcome of a multicenter randomised trial
    • 29. Riethmuller G, Holz E, Schlimok G, Schmiegel W, Raab R, Hoffken K et al. Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomised trial. J Clin Oncol 1998;16:1788-94.
    • (1998) J Clin Oncol , vol.16 , pp. 1788-1794
    • Riethmuller, G.1    Holz, E.2    Schlimok, G.3    Schmiegel, W.4    Raab, R.5    Hoffken, K.6
  • 31
    • 0029586589 scopus 로고
    • Matrix metalloproteinase inhibition: A review of anti-tumor activity
    • 31. Brown PD, Giavazzi R. Matrix metalloproteinase inhibition: a review of anti-tumor activity. Ann Oncol 1995;6:967-74.
    • (1995) Ann Oncol , vol.6 , pp. 967-974
    • Brown, P.D.1    Giavazzi, R.2
  • 32
    • 0000153102 scopus 로고    scopus 로고
    • Prolonged administration of BAY 12-9566, an oral non-peptidic biphenyl matrix metalloproteinase (MMP) inhibitor: A phase I and pharmacokinetic (PK) study
    • abstract #836,216a
    • 32. Rowinsky E, Hammond L, Aylesworth C, Humphrey R, Siu L, Smith L. Prolonged administration of BAY 12-9566, an oral non-peptidic biphenyl matrix metalloproteinase (MMP) inhibitor: a phase I and pharmacokinetic (PK) study. Proc Am Soc Clin Oncol 1998; 17: abstract #836,216a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Rowinsky, E.1    Hammond, L.2    Aylesworth, C.3    Humphrey, R.4    Siu, L.5    Smith, L.6
  • 33
    • 0000550788 scopus 로고    scopus 로고
    • Pharmacokinetics of BAY 12-9566: Early results of a canadian phase I dose escalation study in cancer patients
    • abstract #2484,364
    • 33. Hirte H, Goel R, Major P, Waterfield B, Holohan S, Bennett K, et al. Pharmacokinetics of BAY 12-9566: early results of a Canadian phase I dose escalation study in cancer patients. Proc Am Assoc Cancer Res 1998; 39: abstract #2484,364.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Hirte, H.1    Goel, R.2    Major, P.3    Waterfield, B.4    Holohan, S.5    Bennett, K.6
  • 35
    • 14444284598 scopus 로고    scopus 로고
    • Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumour markers in advanced cancer: Selection of a biologically active and tolerable dose for longer-term studies
    • 35. Nemunaitis J, Poole C, Primrose J, Rosemurgy A, Malfetano J, Brown P, et al. Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumour markers in advanced cancer: Selection of a biologically active and tolerable dose for longer-term studies. Clin Cancer Res 1998;4:1101-11.
    • (1998) Clin Cancer Res , vol.4 , pp. 1101-1111
    • Nemunaitis, J.1    Poole, C.2    Primrose, J.3    Rosemurgy, A.4    Malfetano, J.5    Brown, P.6
  • 36
    • 0002635973 scopus 로고    scopus 로고
    • An open phase I/II study of the oral matrix metalloproteinase inhibitor marimastat in patients with inoperable gastric cancer
    • 36. Parsons SL, Watson SA, Griffin NR, Steele RJC. An open phase I/II study of the oral matrix metalloproteinase inhibitor marimastat in patients with inoperable gastric cancer. Ann Oncol 1996;7:47.
    • (1996) Ann Oncol , vol.7 , pp. 47
    • Parsons, S.L.1    Watson, S.A.2    Griffin, N.R.3    Steele, R.J.C.4
  • 37
    • 0000100112 scopus 로고    scopus 로고
    • A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer
    • abstract #838,217a
    • 37. Adams M, Thomas H. A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer. Proc Am Soc Clin Oncol 1998; 17: abstract #838,217a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Adams, M.1    Thomas, H.2
  • 38
    • 0000632527 scopus 로고    scopus 로고
    • Phase IB study if concurrent administration of marimastat and gemcitabine in non-resectable pancreatic cancer
    • abstract #888,232a
    • 38. Carmichael J, Ledermann J, Woll PJ, Gulliford T, Russell RC. Phase IB study if concurrent administration of marimastat and gemcitabine in non-resectable pancreatic cancer. Proc Am Soc Clin Oncol 1998; 17: abstract #888,232a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Carmichael, J.1    Ledermann, J.2    Woll, P.J.3    Gulliford, T.4    Russell, R.C.5
  • 40
    • 0030055518 scopus 로고    scopus 로고
    • Tumour marker levels during marimastat therapy
    • 40. Gore M, A'Hern R, Stankiewicz M, Slevin M. Tumour marker levels during marimastat therapy. Lancet 1996;348:263-4.
    • (1996) Lancet , vol.348 , pp. 263-264
    • Gore, M.1    A'Hern, R.2    Stankiewicz, M.3    Slevin, M.4
  • 41
    • 0030723230 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors - Present achievements and future prospects
    • 41. Denis LJ, Verweij J. Matrix metalloproteinase inhibitors - present achievements and future prospects. Invest New Drugs 1997;15:175-85.
    • (1997) Invest New Drugs , vol.15 , pp. 175-185
    • Denis, L.J.1    Verweij, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.