In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: Relationship to bone and cartilage degradation

Bone

Volumn 22, Issue 1, 1998, Pages 33-38

  Greenwald, R A ^a   Golub, L M ^b   Ramamurthy, N S ^b   Chowdhury, M ^a   Moak, S A ^a   Sorsa, T ^c  

^a LONG ISLAND JEWISH MEDICAL CENTER   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Collagenase; Gelatinase; Matrix metalloproteinase; Osteoclast; Tetracycline

Indexed keywords

CELL ENZYME; COLLAGENASE; COLLAGENASE 3; DOXYCYCLINE; GELATINASE; GLYCOSAMINOGLYCAN; INTERLEUKIN 1; MATRIX METALLOPROTEINASE; MINOCYCLINE; NEUTROPHIL COLLAGENASE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DESTRUCTION; CARTILAGE DEGENERATION; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME INHIBITION; FIBROBLAST; NONHUMAN; ORGAN CULTURE; OSTEOLYSIS; TIBIA;

ANIMALS; CARTILAGE, ARTICULAR; CATTLE; COLLAGEN; COLLAGENASES; GLYCOSAMINOGLYCANS; HUMANS; INTERLEUKIN-1; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 8; OSTEOCLASTS; RATS; SWINE; TETRACYCLINES; TIBIA;

EID: 0031973365     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00221-4     Document Type: Article

References (42)

1. Billinghurst R. C., Dahlberg L., Ionescu M., Reiner A., Bourns R., Rorabeck C., Mitchell P., Hambor J., Diekmann O., Tschesche H., Chen J., van Wart H., Poole R. A. Enhanced cleavage of Type II collagen by collagenases in osteoarthritic cartilage. J Clin Invest. 99:1997;1534-1545.
2. Chowdhury M. H., Moak S. A., Greenwald R. A. Effect of tetracycline metalloproteinase inhibitors on basal and heparin-stimulated bone resorption by chick osteoclasts. Agents Actions. 40:1993;124-128.
3. Cole A. A., Yi W., Kuettner K., Golub L. M., Greenwald R. A. The effect of chemically modified tetracyclines on cartilage degradation in chicken tibial explants. Trans Orthop Res Soc. 20:1995;337.
4. Cole A. A., Chubinskaya S., Schumacher B., Huch K., Cs-Szabo G., Yao J., Mikecz K., Hasty K. A., Kuettner K. E. Chondrocyte matrix metalloproteinase-8. J Biol Chem. 271:1996;11023-11026.
5. 3H-acetylated collagen. Anal Biochem. 148:1985;174-181.
6. Delaney A. M., Rydziel S., Canalis E. Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors. Endocrinology. 137:1996;4665-4670.
7. Farndale R. W., Buttle D. J., Barrett A. J. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta. 883:1986;173-177.
8. 374 in the interglobular domain of cartilage aggrecan. Biochem J. 304:1994;347-351.
9. Fosang A. J., Last K., Knauper V., Murphy G., Neame P. J. Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Lett. 380:1996;17-20.
10. Freije J. M. P., Diez-Itza I., Balbin M., Sanchez L. M., Blasco R., Tolivia J., Lopez-Otin C. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem. 269:1994;16766-16773.
11. Golub, L. M., Lee, H. M., Greenwald, R. A., Ryan, M. E., Sorsa, T., Salo, T., and Giannobile, W. V. A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflammation Res. In press.
12. Golub L. M., Ciancio S., Ramamurthy N. S., Leung M., McNamara T. F. Low dose doxycycline therapy Effect on gingival and crevicular fluid collagenase activity in humans . J Periodont Res. 26:1990;321-330.
13. Golub L. M., Wolff M., Lee H. M. Further evidence that tetracyclines inhibit collagenase activity in human crevicular fluid and from other mammalian sources. J Periodont Res. 20:1985;12-23.
14. Golub L. M., Ramamurthy N. S., McNamara T. F., Greenwald R. A., Rifkin B. R. Tetracyclines inhibit connective tissue breakdown New therapeutic implications for an old family of drugs . CRC Crit Rev Oral Biol Med. 2:1991;297-322.
15. Golub L. M., Sorsa T., Lee H. M., Ciancio S., Sorbi D., Ramamurthy N. S., Gruber B., Salo T., Konttinen Y. T. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodont. 22:1995;100-109.
16. Gomis-Euth F. X., Gohlke U., Betz M., Knauper V., Murphy G., Lopex-Otin C., Bode W. The helping hand of collagenase-3 (MMP-13) 2.7 Å crystal structure of its C-terminal haemopexin-like domain . J Molec Biol. 264:1996;556-566.
17. Greenwald R. A. Tetracycline derivatives as potential inhibitors of connective tissue degradation. Drug News Perspect. 3:1990;161-166.
18. Greenwald R. A. Treatment of destructive arthritic disorders with MMP inhibitors Potential role of tetracyclines . Ann NY Acad Sci. 732:1994;181-198.
19. Johanson N., Saarialhokere U., Airola K., Herva R., Nissenen L., Westermarck O., Yuorio E., Heino O., Kahari V. M. Collagenase-3 (P-13) is expressed by hypertrophic chondrocytes, periosteal cells and osteoblasts during human fetal bone development. Devel Dynam. 208:1997;387-397.
20. Kozaci L. D., Buttle D. J., Hollander A. P. Degradation of Type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explants. Arthrit Rheum. 40:1997;164-174.
21. Knauper V., Cowell S., Smith B., Lopez-Otin C., O'Shea M., Morris H., Zardi L., Murphy G. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. J Biol Chem. 272:1997;7608-7616.
22. Knauper V., Lopez-Otin C., Smith B., Knight G., Murphy G. Biochemical characterization of human collagenase-3. J Biol Chem. 271:1996;1554-1560.
23. Krane S. M., Byrne M. H., Lemaitre V., Henriet P., Jeffrey J. J., Witter J. P., Liu X., Wu H., Jaenisch R., Eeckhout Y. Different collagenase gene products have different roles in degradation of Type I collagen. J Biol Chem. 271:1996;28509-28515.
24. Lemaitre V., Jungbluth A., Eechhout Y. The recombinant domain of mouse collagenase-3 depolymerizes type I collagen by cleaving its aminotelopeptides. Biochem Biophys Res Commun. 230:1997;202-205.
25. Lovejoy B., Cleasy A., Hassel A. M., Langley K., Luther M. A., Weigl D., McGheehan G., McElroy A. B., Drewry D., Lambert M. H., Jordan S. R. Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. Science. 263:1994;375-377.
26. Mitchell P. G., Magna H. A., Reeves L. M., Lopresti-Morrow L. L., Yocum S. A., Rosner P. J., Geoghegan K. F., Hambor J. E. Cloning, expression, and Type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest. 97:1996;761-768.
27. Mookhtiar K. A., Van Wart H. E. Purification to homogeneity of latent and active 58 kilodalton forms of human neutrophil collagenase. Biochemistry. 29:1990;10620-10627.
28. Nagase H., Woessner J. F. Jr. An improved assay for proteases and polysaccharidases employing a cartilage proteoglycan substrate entrapped in polyacrylamide particles. Anal Biochem. 107:1980;385-392.
29. Pelletier J. M., Pelletier J. P. Wanted - the collagenase responsible for the destruction of the collagen network in human cartilage. Br J Rheum. 35:1996;818-820.
30. Reboul P., Pelletier J. P., Tardif G., Cloutier J. M., Pelletier J. M. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. J Clin Invest. 97:1996;2011-2019.
31. Rifkin B. R., Vernillo A. T., Golub L. M., Ramamurthy N. S. Modulation of bone resorption by tetracyclines. Ann NY Acad Sci. 732:1994;165-180.
32. Ryan M. E., Greenwald R. A., Golub L. M. Potential of tetracyclines to modify cartilage breakdown in osteoarthritis. Curr Opin Rheum. 8:1996;238-247.
33. Ryan M. E., Ramamurthy N. S., Golub L. M. Matrix metalloproteinases and their inhibition in periodontal treatment. Curr Opin Periodont. 3:1996;85-96.
34. Saklatvala J. Tumour necrosis factor stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature. 322:1986;547-549.
35. Smith G. N., Mickler E. A., Hasty K. A., Brandt K. D. Inhibition by doxycycline of a truncated form of recombinant human MMP-13. Arthrit Rheum. 39:(Suppl.):1996;S226.
36. Sorsa T., Ding Y., Salo T., Lauhio A., Teronen O., Ingman T., Ohtani H., Andoh N., Taheka S., Konttinen Y. Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. Ann NY Acad Sci. 732:1994;112-131.
37. Sorsa T., Lukinmaa P. L., Westerlund U., Ingman T., Ding Y., Tschesche H., Konttinen Y. T., Helaakoski T., Salo T. The expression, activation, and chemotherapeutic inhibition of matrix metalloproteinase-8 (neutrophil collagenase/collagenase-2) in inflammation. Davidovitch Z., Norton L. A. Biological Mechanisms of Tooth Movement and Craniofacial Adaptation. 1995;317-323 Harvard University Press, Boston.
38. 1 specificity pocket. Nature Struct Biol. 1:1994;119-123.
39. Suomalainen K., Sorsa T., Golub L. M., Ramamurthy N. S., Uitto V. J., Saari H., Konttinen Y. T. Specificity of the anticollagenase action of tetracyclines Relevance to their anti-inflammatory potential . Antimicrob Agents Chemother. 36:1992;227-229.
40. Tyler J., Sawyer Y. Cartilage explant cultures A model system for the analysis of matrix degradation . Maroudas A., Kuettner K. E. Methods in Cartilage Research. 1990;112-116 Academic, London.
41. Wernicke D., Seyfert C., Hinzmann B., Gromnica-Ihle E. Cloning of collagenase-3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis. J Rheum. 23:1996;590-595.
42. Yu L. P., Smith G. N., Hasty K., Brandt K. D. Doxycycline inhibits Type XI collagenolytic activity of extracts from human osteoarthritic cartilage and gelatinase. Rheumatol. 18:1991;1450-1452.