Effects of doxycycline on human prostate cancer cells in vitro

Cancer Letters

Volumn 127, Issue 1-2, 1998, Pages 37-41

  Fife, Rose S ^a   Sledge Jr , George W ^a   Roth, Bruce J ^a   Proctor, Carmen ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Doxycycline; Human prostate cancer cells; In vitro

Indexed keywords

DNA FRAGMENT; DOXYCYCLINE; GELATINASE; PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; ISOTOPE LABELING; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN SYNTHESIS INHIBITION;

ADENOCARCINOMA; ANTI-BACTERIAL AGENTS; APOPTOSIS; CELL DIVISION; DNA FRAGMENTATION; DOXYCYCLINE; HUMANS; MALE; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0032523857     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00003-2     Document Type: Article

References (22)

1. Liotta L., Tryggvason K., Garbisa S., Hart I., Foltz C., Shafie S. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature. 284:1980;67-68.
2. DeClerck Y., Perez N., Shimada H., Boone T., Langley K., Taylor S. Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res. 52:1992;701-708.
3. Azzam H., Arand G., Lippman M., Thompson E. Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production. J. Natl. Cancer Inst. 85:1993;1758-1764.
4. Moses M., Sudhalter J., Langer R. Identification of an inhibitor of neovascularization from cartilage. Science. 248:1990;1408-1414.
5. Hermeking H., Eick D. Mediation of c-Myc-induced apoptosis by p53. Science. 265:1994;2091-2093.
6. Higashiyama M., Doi O., Kodama K., Yokouchi H., Tateishi R. High prevalence of bcl-2 oncoprotein expression in small cell lung cancer. Anticancer Res. 15:1995;503-505.
7. Yu L., Smith G., Hasty K., Brandt K. Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase. J. Rheum. 18:1991;1450-1452.
8. Smith G., Hasty K., Yu L., Lamberson K., Mickler E., Brandt K. Cleavage of type XI collagen fibers by gelatinase and by extracts of osteoarthritic canine cartilage. Matrix. 11:1991;36-42.
9. Golub L., Lee H., Lehrer G.et al. Minocycline reduces gingival collagenolytic activity during diabetes. J. Period. Res. 18:1983;516-526.
10. Van den Bogert C., Dontje B., Holtrop M., Melis T., Romijn J., van Dongen J., Kroon A. Arrest of the proliferation of renal and prostate carcinomas of human origin by inhibition of mitochondrial protein synthesis. Cancer Res. 46:1986;3283-3289.
11. Guerin C., Laterra J., Masnyk T., Golub L., Brem H. Selective endothelial growth inhibition by tetracyclines that inhibit collagenase. Biochem. Biophys. Res. Commun. 188:1992;740-745.
12. Fife R., Sledge G. Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells. J. Lab. Clin. Med. 125:1995;407-411.
13. Fife R.S., Rougraff B.T., Proctor C., Sledge G.W. Doxycycline inhibits human osteosarcoma cell proliferation and induces apoptosis. J. Lab. Clin. Med. 130:1997;530-534.
14. Fife R.S., Palmoski M.J., Brandt K. Metabolism of a cartilage matrix glycoprotein by normal and osteoarthritic canine articular cartilage. Arthritis Rheum. 29:1986;1256-1262.
15. Birkedal-Hansen H., Taylor R.E. Detergent-activation of latent collagenase and resolution of its component molecules. Biochem. Biophys. Res. Commun. 107:1982;1173-1178.
16. Davies B., Miles D.W., Happerfield L.C., Naylor M.S., Dobrow L.G., Rubens R.D., Balkwill F.R. Activity of type IV collagenases in benign and malignant breast disease. Br. J. Cancer. 67:1993;1126-1131.
17. Armstrong D., Kauffman S., Ottaviano Y., Furuya Y., Buckley J., Isaacs J., Davidson N. EGF-mediated apoptosis of MDA-MB-468 human breast cancer cells. Cancer Res. 54:1994;5280-5283.
18. Armstrong D., Isaacs J., Ottaviano Y., Davidson N. Programmed cell death in an estrogen-independent human breast cancer cell line, MDA-MB-468. Cancer Res. 52:1992;3418-3424.
19. Fife R., Sledge G., Qulali R., Dunn J., Proctor C. Inhibition of growth and matalloproteinase (MP) synthesis in breast cancer in athymic mice (abstract). J. Invest. Med. 43:1995;458A.
20. Sledge G., Qulali M., Bone E., Fife R. Combination matrix metalloproteinase (MMP) inhibition in an athymic mouse xenograft model of human breast cancer (BC) metastasis (abstract). Proc. Am. Assoc. Cancer. Res. 37:1996;92.
21. R.S. Fife, G. Sledge, Effects of doxycycline on cancer cells in vitro and in vivo, Am. J. Med., (1998) in press.
22. M.S. Gordon, L.A. Battiato, D. Jones, B.J. Roth, B. Harrison-Mann, R. Fife, M. Collines, G.W. Sledge, A phase I trial of doxycycline (doxy) in patients with cancer (abstract), Am. Soc. Clin. Oncol. 16 (1997) 226A.