Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3

Carcinogenesis

Volumn 17, Issue 9, 1996, Pages 1805-1811

  Bian, Junhui ^a   Wang, Yuli ^a   Smith, Mark R ^b   Kim, Hyungtae ^c   Jacobs, Christine ^a   Jackman, Joany ^d   Kung, Hsiang Fu ^c   Colburn, Nancy H ^c   Sun, Yi ^a,c  

^a PFIZER INC   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL AGGREGATION; CELL DEATH; CELL GROWTH; COLON CARCINOMA; CONTROLLED STUDY; DNA METHYLATION; EPIDERMIS CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; MONOLAYER CULTURE; MOUSE; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL LINE;

EID: 0029810478     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.9.1805     Document Type: Article

References (43)

1. Docherty, A.J.P., Lyons, A., Smith, B.J., Wright, E.M., Stephens, P.E., Harris, T.J.R., Murphy, G. and Reynolds, J.J. (1985) Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature, 318, 66-69.
2. Stetler-Stevenson, W.G., Krutzsch, H.C. and Liotta, L.A. (1989) Tissue inhibitor of metalloproteinases (TIMP-2): a new member of the metalloproteinase inhibitor family. J. Biol. Chem., 264, 17374-17378.
3. Pavloff, N., Slaskus, P.W., Kishnani, N.S. and Hawkes, S.P. (1992) A new inhibitor of metalloproteinases from chicken: ChIMP-3: a third member of the TIMP family. J. Biol. Chem., 267, 17321-17326.
4. Sun, Y., Hegamyer, G. and Colburn, N.H. (1994) Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Cancer Res., 54, 1139-1144.
5. Leco, K.J., Khokha, R., Pavloff, N., Hawkes, S.P. and Edwards, D.R. (1994) Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J. Biol. Chem., 269, 9352-9360.
6. Silbiger, S.M., Jacobsen, V.L., Cupples, R.L. and Koski, R.A. (1994) Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family. Gene, 141, 293-297.
7. Wick, M., Burger, C., Brusselbach, S., Lucibello, F. and Muller, R. (1994) A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence. J. Biol. Chem., 269, 18953-18960.
8. Upte, S.S., Mattei, M.-G. and Olsen, B. (1994) Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP-3 gene to chromosome 22. Genomics, 19, 86-90.
9. Uria, J.A., Ferrando, A.A., Velasco, G., Freije, J.M.P. And Lopez-Otin, C. (1994) Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family. Cancer Res., 54, 2091-2094.
10. Wilde, C.G., Hawkins, P.R., Coleman, R.T., Levine, W.B., Delegeane, A.M., Okamoto, P.M., Ito, L.Y., Scott, R.W. and Seilhamer, J.J. (1994). Cloning and characterization of human tissue inhibitor of metalloproteinases-3. DNA Cell Biol., 13, 711-718.
11. Huebner, K., Isobe, M., Gasson, J.C., Golde, D.W. and Croce, C.M. (1986). Localization of the gene encoding erythroid potentiating activity to chromosome region Xp11.1-Xp11.4. Am. J. Hum. Genet., 38, 819-826.
12. DeClerck, Y., Szpirer, C., Aly, M.S., Cassiman, J.J., Eeckhout, Y. and Rousseau, G. (1992) The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25. Genomics, 14, 782-784.
13. Denhardt, D.T., Feng, B., Edwards, D.R., Cocuzzi, E.T. and Malyankar, U.M. (1993) Tissue inhibitor of metalloproteinases (TIMP, aka EPA): structure, control of expression and biological functions. Pharmac. Ther., 59, 329-341.
14. Sun, Y., Hegamyer, G., Kim, H., Sithanandam, K., Li, H., Watts, R. and Colburn, N. (1995) Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 (mTIMP-3) and its promoter: specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation. J. Biol. Chem., 270, 19312-19319.
15. Williamson, R.A., Marston, F.A.O., Angal, S. et al. (1990) Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP). Biochem. J., 268, 267-274.
16. Birkedal-Hansen, H., Moore, W.G.I., Bodden, M.K., Windsor, L.J., Birkedal-Hansen, B., DeCarlo, A. and Engler, J.A. (1992) Matrix metalloproteinases: a review. Crit. Rev. Oral Biol. Med., 4, 197-250.
17. Murphy, A.N., Unsworth, E.J. and Stetler-Stevenson, W.G. (1993) Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J. Cell. Physiol., 157, 351-358.
18. Nemeth, J.A. and Goolsby, C.L. (1993) TIMP-2, a growth-stimulatory protein from SV-40-transformed human fibroblasts. Exp. Cell Res., 207, 376-382.
19. Bertaux, B., Hornebeck, W., Eisen, A.Z. and Dubertret, L. (1991) Growth stimulation of human keratinocytes by tissue inhibitor of metalloproteinases. J. Invest. Dermatol., 97, 679-685.
20. Hayakawa, T., Yamashita, K., Tanzawa, K., Uchijima, E. and Iwata, K. (1992) Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells: a possible new growth factor in serum. FEBS Lett., 298, 29-32.
21. Corcoran, M.L. and Stetler-Stevenson, W.G. (1995) Tissue inhibitor of metalloproteinases-2 stimulates fibroblast proliferation via a cAMP-dependent mechanism. J. Biol. Chem., 270, 13453-13459.
22. Sun, Y., Hegamyer, G., Cheng, Y.-J., Hildesheim, A., Chen, J.Y., Chen, I.H., Cao, Y., Yao, K.T. and Colburn, N.H. (1992). An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma. Proc. Natl Acad. Sci. USA, 89, 6516-6520.
23. Sun, Y., Pommier, Y. and Colburn, N.H. (1992) Acquisition of a growth inhibitory response to phorbol ester involves DNA damage. Cancer Res., 52, 1907-1915.
24. Sun, Y., Colburn, N.H. and Oberley, L.W. (1993) Depression of catalase gene expression after immortalization and transformation of mouse liver cells. Carcinogenesis, 14, 1505-1510.
25. Sun, Y., Nakamura, K., Hegamyer, G., Dong, Z. and Colburn, N.H. (1993). No point mutation of H-ras or p53 genes expressed in preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants. Mol. Carcinogenesis, 8, 49-57.
26. Sun, Y., Nakamura, K., Wendel, E. and Colburn, N.H. (1993). Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor suppressor gene isolated from nasopharyngeal carcinoma. Proc. Natl Acad. Sci. USA. 90, 2827-2831.
27. Karlsson, J.-O., Ostwald, K., Kabjorn, C. and Andersson, M. (1994). A method for protein assay in Laemmli buffer. Anal. Biochem., 219, 144-146.
28. Staskus, P.W., Masiarz, F.R., Pallanck, L.J. and Hawkes, S.P. (1991) The 21-kDa protein is a transformation-sensitive metalloproteinase inhibitor of chicken fibroblasts. J. Biol. Chem., 266, 449-454.
29. Smith, M.R., Liu, Y.-L., Kim, N., Rhee, S.G. and Kung, H.F. (1990). Inhibition of serum- and Ras-stimulated DNA synthesis by antibodies to phospholipase C. Science, 247, 1074-1077.
30. Taraboletti, G., Garofalo, A., Belotti, D., Drudis, T., Borsotti, P., Scanziani, E., Brown, P.D. and Giavazzi, R. (1995) Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases. J. Natl Cancer Inst., 87, 293-298.
31. Schultz, R.M., Silberman, S., Persky, B., Bajkowski, A.S. and Carmichael, D.F. (1988). Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. Cancer Res., 48, 5539-5545.
32. Khokha, R., Zimmer, M.J., Graham, C.H., Lala, P.K. and Waterhouse, P. (1992) Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells. J. Natl Cancer Inst., 84, 1017-1022.
33. Khokha, R. (1994) Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. J. Natl Cancer Inst., 86, 299-304.
34. Koop, S., Khokha, R., Schmidt, E.E., MacDonald, I.C., Morris, V.L., Chambers, A.F. and Groom, A.C. (1994) Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth. Cancer Res., 54, 4791-4797.
35. Albini, A., Melchiori, A., Santi, L., Liotta, L.A., Brown, P.D. and Stetler-Stevenson, W. (1991) Tumor cell invasion inhibited by TIMP-2. J. Natl Cancer Inst., 83, 775-779.
36. Montgomery, A.M.P., Mueller, B.M., Reisfeld, R.A., Taylor, S.M. and DeClerck, Y.A. (1994) Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line. Cancer Res., 54, 5467-5473.
37. Khokha, R., Waterhouse, P., Yagel, S., Lala, P.K., Overall, C.M., Norton, G. and Denhardt, D.T. (1989). Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells. Science, 244, 947-950.
38. Witty, J.P., McDonnell, S., Newell, K.J., Cannor, P., Navre, M., Tressler, R.J. and Matrisian, L.M. (1994) Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo. Cancer Res., 54, 4805-4812.
39. Khokha, R. and Denhardt, D.T. (1989) Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion. Invasion Metast., 9, 391-405.
40. Apte, S.S., Olsen, B.R. and Murphy, G. (1995) The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family. J. Biol. Chem., 270, 14313-14318.
41. Singh, N., Sun, Y., Nakamura, K., Smith, M. and Colburn, N.H. (1995) C-JUN/AP1 as possible mediators of tumor necrosis factor-α-induced apoptotic response in mouse JB6 tumor cells. Oncology Res., 7, 353-362.
42. Sun, Y., Kim, H., Parker, M., Stetler-Stevenson, W. and Colburn, N.H. (1996) Lack of suppression of tumor cell phenotype by overexpression of TIMP-3 in mouse JB6 tumor cells: identification of a transfectant with increased tumorigenicity and invasiveness. Anticancer Res., 16, 1-8.
43. Yang, T.-T. and Hawkes, S.P (1992) Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts. Proc. Natl Acad. Sci. USA, 89, 10676-10680.