Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after activation by cytochrome P450 2B1

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 373, Issue 2, 1997, Pages 215-223

  Hengstler, J G ^a   Hengst, A ^a   Fuchs, J ^a   Tanner, B ^a   Pohl, J ^b   Oesch, F ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b ASTA MEDICA AG   (Germany)

Author keywords

4 Hydroxycyclophosphamide; Alkali labile site; Cytochrome P450 2B1; DNA repair; Ionizing radiation; Phosphoramide mustard

Indexed keywords

4 HYDROPEROXYCYCLOPHOSPHAMIDE; CYCLOPHOSPHAMIDE; CYCLOPHOSPHAMIDE DERIVATIVE; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; PHOSPHORAMIDE MUSTARD;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DNA BINDING; DNA CROSS LINKING; DNA REPAIR; DNA STRAND BREAKAGE; DOSE RESPONSE; ENZYME ACTIVITY; GENE EXPRESSION; IN VITRO STUDY; IONIZING RADIATION; LUNG FIBROBLAST; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOTRANSFORMATION; CELL LINE; CRICETINAE; CRICETULUS; CYCLOPHOSPHAMIDE; CYTOCHROME P-450 ENZYME SYSTEM; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; PHOSPHORAMIDE MUSTARDS; TRANSFECTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030694580     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00200-X     Document Type: Article

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