Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin

Journal of Cellular Biochemistry

Volumn 65, Issue 3, 1997, Pages 430-442

  Pozo, David ^a   Reiter, Russel J ^b   Calvo, Juan R ^a   Guerrero, Juan M ^a,c  

^a UNIVERSITY OF SEVILLE   (Spain)

^b Univ TX Hlth Sci Ctr S Antonio ^*  (United States)

^c UNIVERSITY OF SEVILLE   (Spain)

Author keywords

calmodulin; cerebellum; melatonin; nitric oxide; nitric oxide synthase; pineal gland

Indexed keywords

ARGININE; CALMODULIN; MELATONIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PINEAL BODY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SEDATION; SEIZURE;

ANIMALS; ARGININE; CALMODULIN; CEREBELLUM; CITRULLINE; CYCLIC GMP; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; KINETICS; MALE; MELATONIN; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0030930937     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19970601)65:3<430::AID-JCB12>3.0.CO;2-J     Document Type: Article

References (41)

1. Acuña-Castroviejo D, Reiter RJ, Menendez-Pelaez A, Pablos MI, Burgos A (1994): Characterization of high-affinity melatonin binding sites in purified cell nuclei of liver. J Pineal Res 16:100-112.
2. Anton-Tay F, Huerto-Delgadillo L, Ortega-Corona B, Benitez-King G (1993): Melatonin antagonism to calmodulin may modulate multiple cellular functions. In Touitou Y, Arendt J, Pevet P (eds): "Melatonin and the Pineal Gland. From Basic Science to Clinical Application." Elsevier Science Publishers BV.
3. Becker-Andre M, Wiesenberg I, Scaeren-Wiemer N, Andre E, Missbach M, Saurat JH, Carlberg C (1994): Pineal hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J Biol Chem 269:28531-28534.
4. Benitez-King G, Huerto-Delgadillo L, Anton-Tay F (1990): Melatonin effects on the cytoskeletal organization of MDCK and neuroblastoma N1E-115 cells. J Pineal Res 9:209-220.
5. Benitez-King G, Huerto-Delgadillo L, Anton-Tay F (1991): Melatonin modifies calmodulin levels in MDCK and N1E-115 cell lines and inhibits phophodiesterase activity in vitro. Brain Res 557:289-292.
6. 3H-melatonin to calmodulin. Life Sci 53:201-207.
7. Bredt DS, Snyder SH (1989): Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86:9030-9033.
8. Bredt DS, Hwang PW, Glatt CE, Lowenstein C, Reed RR, Snyder SH (1991): Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351:714-718.
9. Bruhwyler J, Chleide E, Liegeois JF, Carreer F (1993): Nitric oxide: A new messenger in the brain. Neurosci Biobehav Rev 17:373-384.
10. Calvo JR, Rafii-El-Idrissi M, Pozo D, Guerrero JM (1995): Immunomodulatory role of melatonin: Specific binding sites in human and rodent lymphoid cells. J Pineal Res 18:119-126.
11. Claustrat B, Brun J, Garrey P, Roussel B, Sassolas G (1986): A once-repeated study of nocturnal plasma melatonin patterns and sleep recordings in six normal young men. J Pineal Res 3:301-310.
12. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, Deng MH (1994): Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 91:1824-1828.
13. Ebisawa T, Karne S, Lerner MR, Reppert SM (1994): Proc Natl Acad Sci USA 91:6133-6137.
14. Faraci FM, Brian JE (1994): Nitric oxide and the cerebral circulation. Stroke 25:692-703.
15. Fariello RG, Bubenik GA, Brown GM, Grota IJ (1977): Epileptogenic action of intraventricularly injected antimelatonin antibody. Neurology 27:567-570.
16. Förstermann U, Pollock JS, Schmidt HHHW, Heller M, Murad F (1991): Calmodulin-dependent endothelium-derived relaxing factor nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci USA 88:1788-1792.
17. Guerrero JM, Reiter RJ (1992): A brief survey of pineal gland-immune system interrelationships. Endocr Res 18: 91-113.
18. Guerrero JM, Calvo JR, Osuna C, Lopez-Gonzalez MA (1994): Binding of melatonin by lymphoid cells in humans and rodents. Adv Pineal Res 7:109-117.
19. Huerto-Delgadillo L, Anton-Tay F, Benitez-King G (1994): Effects of melatonin on microtubule assembly depend on hormone concentration: Role of melatonin as a calmodulin antagonist. J Pineal Res 17:55-62.
20. Knowles RG, Moncada S (1994): Nitric oxide synthase in mammals. Biochem J 298:249-258.
21. Knowles RG, Palacios M, Palmer RMJ, Moncada S (1989): Formation of nitric oxide from L-arginine in the central nervous system: A transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci USA 86:5159-5162.
22. Lerner AB, Case JD (1960): Melatonin. Fed Proc 19:590-592.
23. Lieberman HR, Waldhauser F, Gardfield G, Lynch HJ, Wurtman RJ (1984): Effects of melatonin on human mood and performance. Brain Res 323:201-207.
24. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951): Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
25. Matthies H (1989): In search of cellular mechanisms of memory. Prog Neurobiol 32:277-349.
26. Menendez-Pelaez A, Reiter RJ (1993): Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J Pineal Res 15: 59-69.
27. Miles A, Philbrick DRS (1988): Melatonin and psychiatry. Biol Psychiatry 23:405-425.
28. Moncada S, Palmer RMJ, Higgs EA (1991): Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-134.
29. Moskowitz MA, Wurtman RJ (1977): Pathological states involving the pineal. In Martini I, Besser GM (eds) "Clinical Neuroendocrinology." Orlando, FL: Academic Press.
30. Paul S, Ebadi M (1993): Vasoactive intestinal peptide: Its interaction with calmodulin and catalytic antibodies. Neurochem Int 23:197-214.
31. Philo R, Reiter RJ (1978): Characterization of pinealectomy induced convulsions in the Mongolian gerbil (Meriones unguiculatus). Epilepsia 19:485-492.
32. Pozo D, Reiter RJ, Calvo JR, Guerrero JM (1994): Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 55:PL455-PL460.
33. Reiter RJ (1991): Pineal melatonin: Cell biology of its synthesis and of its physiological interactions. Endocr Rev 12:151-180.
34. Sessat WC, Harrison JK, Barber CM, Zeng D, Durieux ME, D'Angelo DD, Lynch KR, Peach MJ (1992): Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem 267:15274-15276.
35. Shibuki K, Okada D (1991): Endogenous nitric oxide release required for long term synaptic depression in the cerebellum. Nature 349:326-328.
36. Snyder SH, Bredt DS (1991): Nitric oxide as a neuronal messenger. Trends Pharmacol Sci 12:125-128.
37. Stankov B, Fraschini F, Reiter RJ (1991): Melatonin binding sites in the central nervous system. Brain Res Rev 16:245-256.
38. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ (1993): Melatonin: A potent, endogenous hydroxyl scavenger. Endocrine J 1:57-60.
39. Vakkuri O, Leppäluoto J, Vuolteenaho O (1984): Development and validation of a melatonin radioimmunoassay using radioiodinated melatonin as a tracer. Acta Endocrinol 106:152-157.
40. Vallance P, Leone A, Calvert A, Collier J, Moncada S (1992): Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339:572-575.
41. Zhang M, Vogel HJ (1994): Characterization of the calmodulin-binding domain of rat cerebellar nitric oxide synthase. J Biol Chem 269:981-985.