The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin

Journal of Pineal Research

Volumn 23, Issue 2, 1997, Pages 79-89

  Brzozowski, Tomasz ^a   Konturek, Peter Ch ^b   Konturek, Stanislaw J ^a   Pajdo, Robert ^b   Bielanski, Wladyslaw ^a   Brzozowska, Iwona ^a   Stachura, Jerzy ^a   Hahn, Eckhart G ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Free radicals; Gastric blood flow; Gastric cytoprotection; Ischemia; L tryptophan; Melatonin; Stress

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; DNA; GASTRIN; MELATONIN; NONSTEROID ANTIINFLAMMATORY AGENT; SCAVENGER; SOLVENT; TRYPTOPHAN;

ACUTE DISEASE; ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; PATHOLOGY; RADIOIMMUNOASSAY; RAT; REPERFUSION INJURY; STOMACH; STOMACH MUCOSA; STOMACH ULCER; STRESS; VASCULARIZATION; WISTAR RAT;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; FREE RADICAL SCAVENGERS; GASTRIC MUCOSA; GASTRINS; MALE; MELATONIN; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; REPERFUSION INJURY; SOLVENTS; STOMACH; STOMACH ULCER; STRESS; TRYPTOPHAN;

EID: 0031231058     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-079X.1997.tb00339.x     Document Type: Article

References (47)

1. BERTUGLIA, S., P.L. MARCHIAFAVA, A. COLANTUOXI (1996) Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation. Cardiovasc. Res. 31:947-952.
2. BRZOZOWSKI, T., D. DROZDOWICZ, J. MAJKA, S.J. KONTUREK (1992) Studies on gastroprotection induced by capsaicin and papaverine. J. Physiol. Pharmacol. 43:309-322.
3. BRZOZOWSKI, T., P.CH. KONTUREK, S.J. KONTUREK, H. ERNST, J. STACHURA, E.G. HAHN (1995a) Gastric adaptation to injury by repeated doses of aspirin strengthens mucosal defense against subsequent exposure to various strong irritants in rats. Gut 37:749-757.
4. BRZOZOWSKI, T., P. KONTUREK, Z. SLIWOWSKI, A. SZLACHCIC, E.G. HAHN, S.J. KONTUREK (1995b) Adaptive cytoprotection by ammonia and urea-urease system in the rat gastric mucosa. J. Physiol. Pharmacol. 46:471-488.
5. BUBENIK, G.A. (1980) Localization of melatonin in the digestive tract of the rat: Effect of maturation, diurnal variation, melatonin treatment and pinealectomy. Horm. Res. 12:313-323.
6. BUBENIK, G.A. (1986) The effect of serotonin, N-acetylserotonin and melatonin on spontaneous contractions of isolated rat intestine. J. Pineal. Res. 3:41-54.
7. BUBENIK, G.A., R.O. BALL, S.F. PANG (1992) The effect of food deprivation on brain and gastrointestinal tissue levels of tryptophan, serotonin, 5-hydroxyindoleacetic acid, and melatonin. J. Pineal Res. 12:7-16.
8. BUBENIK, G.A., G.M. BROWN, L.T. GROTA (1977) Immunohistochemical localization of melatonin in the rat digestive system. Experientia 33:662-663.
9. BUBENIK, G.A., S. DHANVANTARI (1989) Influence of serotonin and melatonin on some parameters of gastrointestinal activity. J. Pineal Res. 7:333-344.
10. BUBENIK, G.A., S.F. PANG, R. HACKER, P.S. SMITH (1996) Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food. J. Pineal Res. 21:251-256.
11. BURTON, K. (1956) A method for the conditions and mechanism of the diphenylamine reaction of colormetric estimation of deoxynucleic acid. Biochem. J. 62:315-323.
12. CASSONE, V. (1990) Effects of melatonin on vertebrate circadian systems. Trends Neurosci. 13:457-464.
13. CHO, C.H., S.F. PANG, B.W. CHEN, C.J. PFEIFFER (1989) Modulation action of melatonin on serotonin-induced aggravation of ethanol ulceration and changes of mucosal blood flow in rat stomach. J. Pineal Res. 6:89-97.
14. DAS, D., R.K. BANERJEE (1993) Effect of stress on the antioxidant enzymes and gastric ulceration. Mol. Cell. Biochem. 125:1115-1125.
15. GILES, K.W., A. MYERS (1965) An improved diphenylamine method for estimation of deoxyribonucleic acid. Nature 80:93.
16. HARDELAND, R., R.J. REITER, B. POEGGELER, D.-X. TAN (1993) The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation. Neurosci. Biobehav. Rev. 17:347-357.
17. HARLOW, H.J., B.L. WEEKLY (1986) Effect of melatonin on the forces of spontaneous contractions of in vitro rat small and large intestine. J. Pineal. Res. 3:277-284.
18. HUETHER, G. (1993) The contribution of extra pineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia 49:665-670.
19. HUETHER, G. (1994) Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin. Ann. NY. Acad. Sci. 719:146-158.
20. HUETHER, G., B. POEGGELER, A. REIMER, A. GEORGE (1992) Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sci. 51:945-953.
21. ITOH, M., P.H. GUT (1985) Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat: Gastroenterologoy 88:1162-1167.
22. ISHII, K.B., B. CHANG, J.F. KERWIN, Z.J. HUANG, F. MURAD (1990) N-nitro-L-arginine, a potent inhibitor of endothelium-derived relaxing factor formation. Eur. J. Pharmacol. 176:219-222.
23. KAWASHI, T., T. JOH, F. IWATA, M. ITOH (1994) Gastric epithelial damage induced by local ischemia-reperfusion with or without exogenous acid. Am. J. Physiol. 226:G263-270.
24. KONTUREK, P.CH. (1997) Physiological, immunohistochemical and molecular aspects of gastric adaptation to stress, aspirin and H. pylori-derived gastrotoxins. J. Physiol. Pharmacol 48:3-42.
25. KONTUREK, P.K., T. BRZOZOWSKI, S.J. KONTUREK, A. DEMBINSKI (1990) Role of epidermal growth factor prostaglandin and sulfhydryls in stress-induced gastric lesions. Gastroenterology 99:1607-1615.
26. KONTUREK, S.J. (1990) Mechanism of gastroprotection. Scand. J. Gastroenterol. 25:15-28.
27. KONTUREK, S.J., T. BRZOZOWSKI, W. BIELANSKI, A.V. SCHALLY (1995a) Role of endogenous gastrin in gastroprotection. Eur. J. Pharmacol 278:203-212.
28. KONTUREK, S.J., T. BRZOZOWSKI, J. PYTKO-POLONCZYK, D. DROZDOWICZ (1995b) Comparison of cholecystokinin, pentagastrin, and duodenal oleate in gastroprotection in rats. Scand. J. Gastroenterol. 30:620-630.
29. 2 analog with local gastroprotective and ulcer healing activity. Eur. J. Pharmacol. 195:347-357.
30. KONTUREK, S.J., T. BRZOZOWSKI, J. MAJKA, A. DEMBINSKI, A. SLOMIANY, B.L. SLOMIANY (1992a) Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Scand. J. Gastroenterol. 27:649-655.
31. KONTUREK, S.J., T. BRZOZOWSKI, J. MAJKA, A. SZLACHCIC, C. NAUERT, N. SLOMIANY (1992b) Nitric oxide in gastroprotection by aluminum-containing antacids. Eur. J. Pharmacol. 229:155-162.
32. LEE, P.P., S.F. PANG (1993) Melatonin and its receptors in the gastrointestinal tract. Biol. Signals 2:181-93.
33. LEWY, A.J., S. AHMED, J.M. LATHAM JACKSON, R. SACK (1992) Melatonin shifts circadian rhythms according to a phase-response curve. Chronobiol. Int. 9:380-392.
34. LIN, J., X. WANG, A. MORI (1994) Immobilization stress-induced antioxidant defense changes in rat plasma: Effect of treatment with reduced glutathione. Int. J. Biochem. 26:511-517.
35. PENTNEY, P.T., G.A. BUBENIK (1995) Melatonin reduces the severity of dextran-induced colitis in mice. J. Pineal. Res. 19:31-39.
36. QUAY, W.B., Y.H. MA (1976) Demonstration of gastrointestinal hydroxyindole-O-methyltransferase. Int. Rep. Clin. Sci. Med. Sci. Lib. Compend. 4:563-569.
37. RAIKHLIN, N.T., I.M. KVETNOY (1976) Melatonin and enterochromaffin cells. Acta Histochem. 55:19-24.
38. REITER, R.J. (1988) Neuroendocrinology of melatonin. In: Miles, A., D.R.S. Philbrick, C. Thompson, eds. Melatonin: Clinical Perspectives. Oxford, Oxford University Press pp. 1-42.
39. REITER, R.J. (1996) Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals. Eur. J. Endocrinol. 134:412-20.
40. REITER, R.J., D. MELCHIORRI, E. SEWERYNEK, B. POEGGELER, L. BARLOW-WALDEN, J.I. CHUANG, G.G. ORTIZ, D. ACUNACASTROVIEJO (1995) A review of the evidence supporting melatonin's role as an antioxidant. J. Pineal Res. 18:1-11.
41. SALIM, A.S. (1991) Protection against stress-induced acute gastric mucosal injury by free radical scavengers. Intensive-Care Med. 17:455-460.
42. TONO-OKA, T., N. KENO, T. MATSUMOTO, M. OHKAWA, S. MATSUMOTO (1983) Chemiluminescence of whole blood: A simple and rapid method for estimation of phagocytic function of granulocytes and opsonic activity in whole blood. Clin. Immunol. Immunopathol. 26:66-75.
43. UNDERWOOD, H. (1985) Circadian rhythms in lizards: Phase response curve for melatonin. J. Pineal Res. 3:187-196.
44. VAKKURI, O., H. RINTAMAKI, J. LEPPALUOTO (1985) Presence of immunoreactive melatonin in different tissues of the pigeon. Gen. Comp. Endocrinol. 1985:58, 69-75.
45. WADA, K., Y. KAMISAKI, M. KITANO, K. NAKAMOTO, T. ITOH (1995) Protective effect of cystathione on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Eur. J. Pharmacol. 294:377-382.
46. WALDHAUSER, F., G. WEISZENBACHER, E. TATZER, B. GISINGER, M. WALDHAUSER, M. SCHEMPER, H. FRISCH (1988) Alterations in nocturnal serum melatonin levels in humans with growth and aging. J. Clin. Endocrinol. Metab. 66: 648-652.
47. WHITTLE, B.J.R., J. LOPEZ BELMONTE, S. MONCADA (1990) Regulation of gastric mucosal integrity by endogenous nitric oxide, interactions with prostanoids and sensory neuropeptides in the rat. Br. J. Pharmacol. 99:607-611.