Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice

Journal of Pineal Research

Volumn 21, Issue 2, 1996, Pages 108-113

  Yamamoto, Hiro Aki ^a   Tang, Hai Wang ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Excitotoxicity; Free radicals; L cysteine; Lipid peroxidation; Melatonin; Seizures

Indexed keywords

CYSTINE; MALONALDEHYDE; MELATONIN; SCAVENGER;

ANIMAL; ARTICLE; BRAIN; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LIPID METABOLISM; LIPID PEROXIDATION; MALE; METABOLISM; MOUSE; SEIZURE; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BRAIN; CYSTINE; FREE RADICAL SCAVENGERS; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SUBCUTANEOUS; LIPID METABOLISM; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MELATONIN; MICE; SEIZURES;

EID: 0030229801     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-079X.1996.tb00277.x     Document Type: Article

References (46)

1. AIZEMNMAN, E., K.A. HARTNETT, I.J. REYNOLDS (1990) Oxygen free radicals regulate NMDA receptor function via redox modulatory site. Neuron 5:841-846.
2. ANDINE, P., O. ORWAR, I. JACOBSON, M. SANDBERG, H. HAGBERG (1991) Extracellular acidic sulfur-containing amino acids and gamma-glutamyl peptides in global ischemia: Postischemic recovery of neuronal activity is paralleled by a tetrodotoxin-sensitive increase in cysteine sulfinate in the CA1 of the rat hippocampus. J. Neurochem. 57:230-236.
3. BELINSKY, S.T., F.W. KARI, F.C. KAUFFMAN, R.G. THURMAN (1987) Effect of β-naphthoflavone on mitochondrial supply of reducing equivalents for monooxygenation in periportal and pericentral regions of the liver lobule. Mol. Pharmacol. 32:315-320.
4. BONFOCO, E., D. KRAINC, M. ANKARCRONA, P. NICOTERA, S.A. LIPTON (1995) Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in corical cell cultures. Proc. Natl. Acad. Sci. U.S.A. 92:7162-7166.
5. CHOI, D.W. (1985) Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci. Lett. 58:293-297.
6. CHOI, D.W., J.Y. KOH, S. PETERS (1988) Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists. J. Neurosci. 8:185-196.
7. DINGLEDINE, R., C.J. MCBAIN, J.O. MCNAMARA (1990) Excitatory amino acid receptors in epilepsy. Trends Physiol. Sci., 11:334-338.
8. ESTERBAUER, H., K.H. CHESSEMAN (1990) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Meth. Enzymol. 186:407-421.
9. FERKANY, J., J.T. COYLE (1986) Heterogeneity of sodium-dependent excitatory amino acid uptake mechanisms in rat brain. J. Neurosci. Res. 16:491-503.
10. 3H]aspartate from cerebral cortical synaptosomes. J. Neurochem. 62:1757-1763.
11. GIUSTI, P., M. GUSELLA, M. LIPARTITI, D. MILANI, W. ZHU, S. VICINI, H. MANEV (1995) Melatonin protects primary cultures of cerebrellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity. Exp. Neurol. 131:39-46.
12. GOEL, R., O.P. MISHRA, B. RAZDAN, M. DELIVORIA-PAPADOPOULOS (1993) Modification of NMDA receptor by in vitro lipid peroxidation in fetal guinea pig brain. Neurosci. Lett. 151:219-223.
13. HALL, J. G., T.P. HICKS, H. MCCLENNAN (1978) Kainic acid and the glutamate receptor. Neurosci. Lett. 8:171-175.
14. HARRIS, R. A., L. S. HARRIS, A. DUNN (1975) Effect of narcotic drugs on ribonucleic acid and nucleotide metabolism in mouse brain. J. Pharmacol. Exp. Then 192:280-287.
15. 2 mixed-function oxidation system. J. Biol. Chem. 263:4704-4711.
16. KÖHLER, C. (1984) Neuronal degeneration after intracerebral injections of excitotoxins: A histological analysis of kainic acid, ibotenic acid and quinolinic acid lesions in the rat. In: Excitotoxins. K. Fuke, P. Roberts, R. Schwarcz, eds. Plenum Press, New York, pp. 99-111.
17. LIPTON, S.A., J.S. STAMLER (1994) Actions of redox related congeners of nitric oxide at the NMDA receptor. Neuropharmacology. 33:1229-1233.
18. LOWRY, O.H., N.J. ROSEBROUGH, A.L. FARR, R.J. RANDALL (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem. 193:265-275.
19. LUND KARLSEN, R., I. GROFOVA, D. MALTHE-SORENSSEN, F. FONNUM (1981) Morphological changes in rat brain induced by L-cysteine injection in newborn animals. Brain Res. 208:167-180.
20. MELCHIORRI, D., R.J. REITER, A.M. ATTIA, M. HARA, A. BURGOS, G. NISTICO (1995a) Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats. Life Sci. 56:83-89.
21. MELCHIORRI, D., R.J. REITER, E. SEWERYNEK, L.D. CHEN, G. NISTICO (1995b) Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. FASEB J. 9:1205-1210.
22. MELDRUM, B., J. GARTHWAITE (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Physiol. Sci. 11:379-387.
23. MELDRUM, B., J. GARTHWAITE (1991) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends in Physiological Science Special Report: The Pharmacology of Excitatory Amino Acids 12:54-62.
24. MISRA, H.P. (1974) Generation of superoxide free radical during the autoxidation of thiols. J. Biol. Chem. 249:2151-2155.
25. NAKANSHI, S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603.
26. NATH, K.A., A.K. SALAHUDEEN (1993) Autooxidation of cysteine generates hydrogen peroxide: Cytotoxicity and attenuation of pyruvate. Am. J. Physiol. 264:F306-F314.
27. OLNEY, J.W., O.-L. Ho (1970) Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature 227:609-611.
28. OLNEY, J.W., O.-L. Ho, V. RHEE, B. SCHAKKER (1971) Cysteine-induced brain damage in infant and fetal rodents. Brain Res. 45:309-313.
29. OLNEY, J.W., C. ZORUMSKI, M.T. PRICE, J. LABRUYERE (1990) L-cysteine, a bicarbonate-sensitive endogenous excitotoxin. Science 248:596-599.
30. PIERI, C., M. MARRA, F. MORONI, R. RECCHIONI, F. MARCHESELLI (1994) Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci. 55:271-276.
31. PUKA-SUNDVALL, M., P. ERIKSSON, M. NILSSON, M. SANDBERG, A. LEHMANN (1995) Neurotoxicity of cysteine: Interaction with glutamate. Brain Res. 705:65-70.
32. REITER, R.J., D.-X. TAN, B. POEGGELER, A MENENDEZ-PELAEZ, L.D. CHEN, S. SAARELA (1994) Melatonin as a free radical scavenger: Implications for aging and age-related diseases. Ann. N.Y.Acad.Sci. 719:1-12.
33. REITER, R.J., D. MELCHIORRI, E. SEWERYNEK, B. POEGGELER, L. BARLOW-WALDON, J.-I. CHUANG, G.G ORTIZ, D. ACUÑA-CASTROVIEJO (1995) A review of the evidence supporting melatonins role as an antioxidant. J. Pineal. Res. 18:1-11.
34. SAEZ, G., P.J. THORNALLEY, H.A.O. HILL, R. HEMS, J.V. BANNISTER (1982) The peroduction of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes. Biochem. Biophys. Acta 719:24-31.
35. SCHARFMAN, H.E., P.A. SCHWARTZKROIN (1989) Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation. Science 246:257-260.
36. SCHOEPP, D.D., P.J. CONN (1993) Metabotropic glutamate receptors in brain function and pathology. Trends Physiol. Sci. 14:13-20.
37. SCHURR, A. G.A. WEST, M.F. HEINE, B.M. RIGOr (1993) The neurotoxicity of sulfur-containing amino acids in energy deprived rat hippocampal slices. Brain Res. 601:317-320.
38. 3H]MK-801 binding to the phencyclidine recognition site and is thus an agonist for the N-methyl-D-aspartate-operated cation channel. Neuroscience 37:193-200.
39. SHIDA, C.S., A.M.L. CASTRUCCI, M.T. LAMY-FREUND (1994) High melatonin solubility in aqueous medium. J. Pineal Res. 16:198-201.
40. SLIVKA, A., G. COHEN (1993) Brain ischemia markedly elevates levels of the neurotoxic amino acid, cysteine. Brain Res. 608:33-37.
41. TAN, D.-X., L.-D. CHEN, B. POEGGELER, L.C. MANCHESTER, R.J. REITER (1993a) Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocrine J. 1:57-60.
42. TAN, D.-X., B. POEGGELER, R.J. REITER, L.-D. CHEN, S. CHEN, L.C. MANCHESTER, R. BARLOW-WALDEN (1993b) The pineal hormone melatonin inhibits DNA adduct formation induced by the chemical carcinogen safrole in vivo. Cancer Lett. 70:65-71.
43. WATSON, G.B., R.K. RADER, T.H. LANTHÓRNE (1989) Epiletiform activity in vitro can produce long term synaptic failure and persistent neuronal depolarization. Brain Res. 498:81-88.
44. G-nitro-L-arginine against L-cysteine-induced seizures in mice. Toxicol. Lett. 84:1-5.
45. YAMAMOTO, H.-A., H.-W. TANG (1996a) Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice. Neurosci. Lett. 207:89-92.
46. YAMAMOTO, H.-A., H.-W. TANG (1996b) Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice. Toxicol. Lett. 87:19-24.