Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan

Journal of Pineal Research

Volumn 32, Issue 3, 2002, Pages 149-162

  Brzozowska, Iwona ^a   Konturek, Peter C ^b   Brzozowski, Tomasz ^a   Konturek, Stanislaw J ^a   Kwiecien, Slawomir ^a   Pajdo, Robert ^a   Drozdowicz, Danuta ^a   Pawlik, Michal ^a   Ptak, Agata ^a   Hahn, Eckhart G ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Calcitonin gene related peptide; Capsaicin; Gastric blood flow; L tryptophan; Melatonin; Nitric oxide; Prostaglandins; Sensory nerves; Ulcer healing

Indexed keywords

ACETIC ACID; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; DEXTRO ARGININE; GASTRIN; INDOMETACIN; LUZINDOLE; MELATONIN; MELATONIN RECEPTOR; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEPSIN A; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOSE RESPONSE; HYPEREMIA; MALE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; SENSORY NERVE; STOMACH ACID; STOMACH BLOOD FLOW; STOMACH FISTULA; STOMACH ULCER; ULCER HEALING;

ACTINS; ANIMALS; CAPSAICIN; DINOPROSTONE; ENZYME INHIBITORS; GASTRIC MUCOSA; GASTRINS; MALE; MELATONIN; NEURONS, AFFERENT; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PROSTAGLANDINS; RATS; RATS, WISTAR; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, MELATONIN; REGIONAL BLOOD FLOW; STOMACH ULCER; TRYPTAMINES; TRYPTOPHAN;

EID: 0036223640     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079x.2002.1o811.x     Document Type: Article

References (68)

1. Inhibition of inducible nitric oxide synthase delays gastric ulcer healing in the rat
2. Changes of nitric oxide and growth factors during gastric ulcer healing
3. Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical
4. 2 receptors
5. The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia and aspirin
6. Importance of nitric oxide and capsaicin-sensitive afferent nerves in healing of stress lesions induced by epidermal growth factor
7. Role of L-arginine, a substrate for nitric oxide synthase, in gastroprotection and ulcer healing
8. Acceleration of ulcer healing by cholecystokinin (CCK); role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves
9. Role of prostaglandin-generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion induced gastric lesions
10. Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor
11. Role of capsaicin-sensitive sensory nerves in gastroprotection against acid-independent and acid-dependent ulcerogens
12. The effect of food deprivation on brain and gastrointestinal tissue levels of tryptophan, serotonin, hydroxyindoleacetic acid and melatonin
13. Prospects of the clinical utilization of melatonin
14. Relationship between melatonin levels in plasma and gastrointestinal tissues and the incidence and severity of gastric ulcers in pigs
15. Pinealectomy reduces melatonin levels in the serum but not in the gastrointestinal tract of rats
16. Immunohistological localization of melatonin in the digestive system of the rat
17. Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food
18. Modulating action of melatonin on serotonin-induced aggravation of ethanol ulceration and changes of mucosal blood flow in rat stomachs
19. Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats
20. Melatonin reduces dinitrobenzene sulfonic acid-induced colitis
21. Melatonin protects against gastric ischemia-reperfusion injury in rats
22. Pharmacology and function of melatonin receptors
23. Melatonin receptors are there multiple subtypes?
24. Eicosanoids and the gastrointestinal tract
25. Melatonin expression of the inducible isoform of nitric oxide synthase in murine macrophages: Role of inhibition of NFkappaB activation
26. A role for calcitonin gene-related peptide in protection against gastric ulceration
27. Nitrate synthesis in the germ-free and conventional rat
28. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons
29. The contribution of extra pineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates
30. Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin
31. The metabolic fate of infused L-tryptophan in men; possible clinical implications of the accumulation of circulating tryptophan and tryptophan metabolites
32. Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract
33. Nitric oxide-mediated vasorelaxation
34. Central effect of melatonin against stress-induced gastric ulcers in rats
35. Protective role of melatonin and pineal gland in modulating water immersion restraint stress ulcer in rats
36. Mechanism of gastroprotection
37. Role of endogenous gastrin in gastroprotection
38. Comparison ofcholecystokinin, pentagastrin, and duodenal oleate in gastroprotection in rats
39. Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Time sequence study
40. Melatonin affords protection against gastric lesions induced by ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effects
41. Gastroprotective activity of melatonin and its precursor, L-tryptophan, against stress-induced and ischemia-induced lesions is mediated by scavenge of oxygen radicals
42. Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers
43. Healing of oral and gastric ulcers: Effects of blood flow, epidermal growth factor and sensory innervation
44. Involvement of nitric oxide and prostaglandins in gastroprotection induced by bacterial lipopolisaccharide
45. Role of leptin in ulcer healing
46. 2, colloidal bismuth and sucralfate in rats
47. Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery
48. Melatonin and its receptors in the gastrointestinal tract
49. Hypergastrinemia increases proliferation of gastroduodenal epithelium during gastric ulcer healing in rats
50. Suppressive effect of melatonin administration on ethanol-induced gastroduodenal injury in rats in vivo
51. Nitric oxide: Physiology, pathophysiology and pharmacology
52. Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharide in rat
53. 1-antagonists
54. A method for experimental penetrating gastric and duodenal ulcers in rats
55. Melatonin and structurally-related endogenous indoles act as potent electron donors and radical scavengers in vitro
56. Demonstration of gastrointestinal hydroxy-indo-methyl-transferase
57. Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals
58. A review of the evidence supporting melatonin's role as an antioxidant
59. Melatonin reduces both basal and bacterial lipopolysaccharide-induced lipid peroxidation in vitro
60. Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin
61. Lipopolisaccharide-induced DNA damage is greatly reduced in rats treated with the pineal hormone melatonin
62. Regulation by endogenous interleukin-1 of mRNA expression of healing-related factors in gastric ulcers in rats
63. The role of capsaicin-sensitive sensory neurons in healing of HCl-induced gastric mucosal lesions in rats
64. Influence of capsaicin-sensitive afferent fibers on acetic acid induced chronic gastric ulcers in rats
65. Regulation of gastric mucosal integrity by endogenous nitric oxide, interactions with prostanoids and sensory neuropeptides in the rat
66. Tryptophan loading increases daytime serum melatonin levels in intact and pinealectomized rats
67. Effect of acute tryptophan depletion on nocturnal melatonin secretion in humans