Melatonin and structurally-related, endogenous indoles act as potent electron donors and radical scavengers in vitro

Redox Report

Volumn 2, Issue 3, 1996, Pages 179-184

  Poeggeler, B ^a   Reiter, R J ^a   Hardeland, R ^b   Tan, D X ^a   Barlow Walden, L R ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000591863     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1080/13510002.1996.11747046     Document Type: Article

References (11)

1. Reiter R J. The melatonin message: duration versus coincidence hypothesis. Life Sci 1988; 40: 2119-2131.
2. Poeggeler B, Reiter R J, Tan D -X, Chen L -D, Manchester L C. Melatonin, hydroxyl radical-mediated oxidative damage, and aging: A hypothesis. J Pineal Res 1993; 14: 151-168.
3. Reiter R J, Tan D-X, Poeggeler B, Menendez-Pelaez A, Chen L -D, Saarela S. Melatonin as a free radical scavenger: Implications for aging and age-related diseases. Ann NY Acad Sci 1994; 719: 1-12.
4. Reiter R J, Melchiorri D, Sewerynek E et al. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995; 18: 1-11.
5. Menendez-Pelaez A, Poeggeler B, Reiter R J, Barlow-Walden L R, Pablos MI, Tan D-X. Nuclear localization of melatonin in different tissues: Immunocytochemical and radioimmunoassay evidence. J. Cell Biochem 1993; 53: 373-382.
6. Hardeland R, Reiter R J, Poeggeler B, Tan D-X The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances. Neurosci Biobehav Rev 1993; 17:347-357.
7. Wilson R. L. Iron and hydroxyl free radicals in enzyme inactivation and cancer. In: McBrian D C H, Slater T F, eds. Free Radicals, Lipids, Peroxidation and Cancer. London: Academic Press, 1982: 275-304.
8. Tan D-X, Chen L-D, Poeggeler B, Manchester L C, Reiter R J. Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocrine J 1993; 1: 57-60.
9. Pieri C, Maurizio M, Moroni F, Recchioni R, Marcheselli F. Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci 1994; 55:271-276.
10. Pieri C, Moroni F, Marra M, Marcheselli F, Recchioni R. Melatonin is an efficient antioxidant. Arch Gerontol Geriatr 1995; 20: 159-165.
11. Poeggeler B, Saarela S, Reiter R J et al. Melatonin - A highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro. Ann NY Acad Sci 1994; 738:419-420.