Melatonin in Epilepsy: First Results of Replacement Therapy and First Clinical Results

NeuroSignals

Volumn 8, Issue 1-2, 1999, Pages 105-110

  Fauteck, J D ^a   Schmidt, H ^b   Lerchl, A ^b   Kurlemann, G ^b   Wittkowski, W ^b  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Epilepsy; Melatonin; Sleep disorders

Indexed keywords

ANTICONVULSIVE AGENT; MELATONIN; MELATONIN RECEPTOR; NEUROTRANSMITTER; PINEAL BODY HORMONE;

ARTICLE; CHILD; CLINICAL ARTICLE; DARKNESS; EPILEPSY; FEMALE; HORMONE RELEASE; HUMAN; MALE; NEOCORTEX; ORAL DRUG ADMINISTRATION; SLEEP DISORDER; TREATMENT OUTCOME;

ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; CIRCADIAN RHYTHM; DRUG ADMINISTRATION SCHEDULE; EPILEPSY; FEMALE; HUMANS; INFANT; MALE; MELATONIN; SLEEP; SLEEP DISORDERS;

EID: 0033032486     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000014577     Document Type: Article

References (18)

1. Rusak B: The role of the suprachias-matic nuclei in the generation of circadian rhythms in the golden hamster, Mesocricetus auratus. J Comp Physiol 1977;118:145-164
2. Attanasio A, Borelli P, Gupta D: Circadian rhythms in serum melatonin from infancy to adolescence. J Clin Endocrinol Metab 1985;61: 388-390.
3. Czeisler CA, Shanahan TL, Kler-man EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF: Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med 1995;332: 6-11.
4. Palm L, Blennow G, Wetterberg L: Correction of non-24-hour sleep/ wake cycle by melatonin in a blind retarded boy. Ann Neurol 1991;29: 336-339.
5. Sack RL, Lewy AJ, Blood ML, Stevenson J, Keith LD: Melatonin administration to blind people: Phase advances and entrainment. J Biol Rhythms 1991;6:249-261.
6. Cardinali DP, Lynch HJ, Wurtman RJ: Binding of melatonin to human and rat plasma proteins. Endocrinology 1972;91:1213-1218.
7. Riad FD, Read GF, Walker RF, Griffiths K: Steroids in saliva for assessing endocrine function. En-docr Rev 1982;3:367-395.
8. Kauppila A, Kivela A, Parakinen A, Vakkuri O: Inverse seasonal relationship between melatonin and ovarian activity in humans in a region with a strong seasonal contrast in luminosity. J Clin Endocrinol Metab 1987;65:823-828.
9. Graf E, Graf P, Brown GM, Arato M, Lane J: Investigations of melatonin secretion in man. Prog Neu-ropsychopharmacol Biol Psychiatry 1985;9:609-612.
10. Miles A, Philbrick DR, Thomas DR, Grey J: Diagnostic and clinical implications of plasma and salivary melatonin assay. Clin Chem 1987; 33:1295-1297.
11. Garcia-Patterson A, Puig-Domingo M, Webb SM: Thirty years of human pineal research: Do we know its clinical relevance? J Pineal Res 1996;20:1-6.
12. Jan JE, Espezel H, Appleton RE: The treatment of sleep disorders with melatonin. Dev Med Child Neurol 1994;36:97-107.
13. Fariello RG, Bubenik GA, Brown GM, Groto LJ: Epileptogenic action of intraventricularly injected antimelatonin antibody. Neurology 1977;27:567-570.
14. Champney TH, Champney JA: Novel anticonvulsant action of chronic melatonin in gerbils. Neuroreport 1992;3:1152-1154.
15. Champney TH, Hanneman WH, Legare ME, Appel K: Acute and chronic effects of melatonin as an anticonvulsant in male gerbils. J Pineal Res 1996;20:79-83.
16. 2+ epileptiform activity in human temporal slices. Exp Brain Res 1995;107:321-325.
17. Arendt J: Melatonin. Clin Endocrinol (Oxf) 1988;29:205-229.
18. Kurlemann G: Epilepsie und Hormone. Gottingen, Hogrefe Verlag, 1993.