Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants

Journal of Pineal Research

Volumn 28, Issue 2, 2000, Pages 73-80

  Lopez Gonzalez, Miguel A ^a   Guerrero, Juan M ^b   Rojas, Francisco ^b   Delgado, Francisco ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Antioxidants; Cisplatin; Distortion products; Melatonin; Otoacoustic emmisions; Ototoxicity; Outer hair cells; Pineal gland

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL SUCCINATE; ANTIOXIDANT; ASCORBIC ACID; CISPLATIN; GLUTATHIONE; MELATONIN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORTI ORGAN; DISTORTION PRODUCT OTOACOUSTIC EMISSION; DRUG INDUCED DISEASE; EAR PROTECTION; FEMALE; HAIR CELL; HORMONE ACTION; NONHUMAN; OTOTOXICITY; PINEAL BODY; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CISPLATIN; EAR DISEASES; FEMALE; HAIR CELLS, OUTER; MELATONIN; OTOACOUSTIC EMISSIONS, SPONTANEOUS; RATS; RATS, WISTAR;

EID: 0033997664     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079X.2001.280202.x     Document Type: Article

References (83)

1. AOKI, E., R. SEMBA, S. KASHIWAMATA (1991) Evidence for the presence of L-arginine in the glial components of the peripheral nervous system. Brain Res. 559:159-162.
2. ALLEN, G.C., C. TIU, K. KOIKE, A.K. RITCHEY, M. KURS-LASKY, M.K. WAX (1998) Transient-evoked otoacoustic emissions in children after cisplatin chemotherapy. Otolaryngol. Head Neck Surg. 118:584-588.
3. BECK, A., J. MAURER, H.J. WELKOBORSKY, W. MANN (1992) Changes in transitory evoked otoacoustic emissions in chemotherapy with cisplatin and 5FU. HNO 40:123-127.
4. BENOT, S., P. MOLINERO, M. SOUTTO, R. GOBERNA, J.M. GUERRERO (1998) Circadian variations in the rat serum total antioxidant status: Correlation with melatonin levels. J. Pineal Res. 25:1-4.
5. BIESALSKI, H.K., H.A. WELKER, R. THALMANN, L. VOLLRATH (1988) Melatonin and other serotonin derivatives in the guinea pig membranous cochlea. Neurosci. Lett. 91:41-46.
6. BOKEMEYER, C., C.C. BERGER, J.T. HARTMANN, C. KOLLMANNSBERGER, H.J. SCHMOLL, M.A. KUCZYK, L. KANZ (1998) Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer. Br. J. Cancer 77:1355-1362.
7. BRECHTELSBAUER, P.B., A.L. NUTTALL, J.M. MILLER (1994) Basal nitric oxide production in regulation of cochlear cells. Hearing Res. 77:38-42.
8. BRIEN, J.A. (1993) Ototoxicity associated with salicylates. A brief review. Drug Safety 9:143-148.
9. CAMPBELL, K.C., L.P. RYBAK, R.P. MEECH, L. HUGHES (1996) D-methionine provides excellent protection from cisplatin ototoxicity in the rat. Hearing Res. 102:90-98.
10. CLERICI, W.J., D.L. DIMARTINO, M.R. PRASAD (1995) Direct effects of reactive oxygen species on cochlear outer hair cell shape in vitro. Hearing Res. 84:30-40.
11. CLERICI, W.J. (1996) Effects of superoxide dismutase and U74389G on acute trimethyltin-induced cochlear dysfunction. Toxicol. Appl. Pharmacol. 136:236-242.
12. CLERICI, W.J., L. YANG (1996) Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hearing Res. 101:14-22.
13. CLERICI, W.J., K. HENSLEY, D.L. DIMARTINO, D.A. BUTTERFIELD (1996) Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hearing Res. 98:116-124.
14. CUZZOCREA, S., G. CONSTANTINO, A.P. CAPATI (1998) Protective effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthase activation in a non septic shock model induced by zymosan in the rat. J. Pineal Res. 24:78-85.
15. DUBOCOVICH, M.L. (1985) Characterization of a retinal melatonin receptor. J. Pharmacol. Exp. Ther. 234:395-401.
16. FESSENDEN, J.D., D.E. COLING, J. SCHACHT (1994) Detection and characterization of nitric oxide synthase in the mammalian cochlea. Brain Res. 668:9-15.
17. FORD, M.S., Z. NIE, C. WHITWORTH, L.P. RYBAK, V. RAMKUMAR (1997) Up-regulation of adenosine receptors in the cochlea by cisplatin. Hearing Res. 111:143-152.
18. FOSTER-NORA, J.A., R. SIDEN (1997) Amifostine for protection from antineoplastic drug toxicity. Am. J. Health Syst. Pharm. 54:787-800.
19. FREEMAN, S., L. CHERNY, H. SOHMER (1996) Thyroxine affects physiological and morphological development of the ear. Hearing Res. 97:12-29.
20. GABAIZADEH, R., H. STAECKER, W. LIU, R. KOPKE, B. MALGRANGE, P.P. LEFEVRE, T.R. VAN-DER-WATER (1997) Protection of both auditory hair cells and auditory neurons from cisplatin induced damage. Acta Otolaryngol. (Stockh.) 117:232-238.
21. GARCIA-MAURIÑO, S., M.G. GONZALEZ-HABA, J.R. CALVO, M. RAFH-EL-IDRISSI, V. SANCHEZ-MARGALET, R. GOBERNA, J.M. GUERRERO (1997) Melatonin enhances IL-2, IL-6 and IFNgamma production by human circulating CD4+ cells: A possible nuclear receptor-mediated mechanism involving Th1 lymphocytes and monocytes. J. Immunol. 159:574-581.
22. GUERRERO, J.M., R.J. REITER (1992) A brief survey of pineal gland-immune system interrelationships. Endocr. Res. 18:91-113.
23. GUERRERO, J.M., M.A. LOPEZ-GONZALEZ, C. OSUNA, J.R. CALVO (1994) Specific binding of melatonin by immuno-competent cells in humans and rodents: Modifications during postnatal development. Ann. N.Y. Acad. Sci. 719:369-377.
24. GUERRERO, J.M., R.J. REITER, G.G. ORTIZ, M.I. PABLOS, E. SEWERYNEK, J.I. CHUANG (1997) Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones unguiculatus). J. Pineal Res. 23:24-31.
25. HALLIWELL, B., J.M.C. GUTTERIDGE (1995) Oxygen radicals and the nervous system. Trends Neurosci. 79:22-26.
26. HARTNICK, C.J., A.F. COHEN, R.V. SMITH (1997) Reversible sensorineural hearing loss after renal transplant immunosuppression with OKT3 (muromonab-CD3). Ann. Otol. Rhinol. Laryngol. 106:640-642.
27. HENLEY, C.M., L.P. RYBAK (1993) Developmental ototoxicity. Otolaryngol. Clin. North Am. 26:857-871.
28. HENLEY, C.M. (1994) Kanamycin depletes cochlear polyamines in the developing rat. Otolaryngol. Head Neck Surg. 110:103-109.
29. HENLEY, C.M., L.P. RYBAK (1995) Ototoxicity in developing mammals. Brain Res. Rev. 20:68-90.
30. HENLEY, C.M., R.A. WEATHERLY, G.K. MARTIN, B. LONSBURY-MARTIN (1996) Sensitive developmental periods for kanamycin ototoxic effects on distortion-product otoacoustic emissions. Hearing Res. 98:93-103.
31. ILVESKOSKI, I., U.M. SAARINEN, T. WIKLUND, M. PERKKIO, T.T. SALMI, M. LANNING, A. MAKIPERNAA, N. PIHKO (1996) Ototoxicity in children with malignant brain tumors treated with the "8 in 1" chemotherapy protocol. Med. Pediatr. Oncol. 27:26-31.
32. JOHNSON, A.C. (1993) The ototoxic effect of toluene and the influence of noise, acetyl salicylic acid, or genotype. A study in rats and mice. Scand. Audiol. Suppl. 39P:1-40.
33. KALTENBACH, J.A., M.W. CHURCH, B.W. BLAKLEY, D.L. MCCASLIN, D.L. BURGIO (1997) Comparison of five agents in protecting the cochlea against the ototoxic effects of cisplatin in the hamster. Otolaryngol. Nead Neck Surg. 117:493-500.
34. KEMP, D.T. (1978) Stimulated acoustic emissions from within the human auditory system. J. Acoust. Soc. Am. 64:1386-1391.
35. KEMP, D.T., R. CHUM (1980) Properties of the generator of stimulated acoustic emissions. Hearing Res. 2:213-232.
36. KEMP, DT, S. RYAN, P.A. BRAY (1990) A guide to the effective use of otoacoustic emissions. Ear Hear 11:93-105.
37. KHVOLES, R., S. FREEMAN, H. SOHMER (1996) Transient evoked otoacoustic emissions can be recorded in the rat. Hearing Res. 97:120-126.
38. KNIGHT, J.A. (1995) Diseases related to oxygen-derived free radicals. Ann. Clin. Lab. Sci. 25:111-121.
39. KNOWLES, R.G., S. MONCADA (1992) Nitric oxide as a signal in blood vessels. Trends Biochem. Sci. 17:399-402.
40. KOPKE, R.D., W. LIU, R. GABAIZADEH, A. JACONO, J. FEGHALI, D. SPRAY, P. GARCIA, H. STEINMAN, B. MALGRANGE, R.J. RUBEN, L. RYBAK, T.R. VAN-DER-WATER (1997) Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am. J. Otol. 18:559-571.
41. KOSSL, M., G. FRANK, H. BURDA, M. MULLER (1996) Acoustic distortion products from the cochlea of the blind African mole rat. J. Comp. Physiol. 178:427-434.
42. LAUTERMANN, J., B. SONG, J. MCLAREN, J. SCHACHT (1995) Diet is a risk factor in cisplatin ototoxicity. Hearing Res. 88:47-53.
43. LOPEZ-GONZALEZ, M.A., J.R. CALVO, A. RUBIO, R. GOBERNA, J.M. GUERRERO (1991) Characterization of melatonin binding sites in the Harderian gland and median eminence of the rat. Life Sci. 48:1165-1171.
44. LOPEZ-GONZALEZ, M.A., J.R. CALVO, C. OSUNA, J.M. GUERRERO (1992) Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP. J. Pineal Res. 12:97-104.
45. 125I-melatonin by partially purified membranes of rat thymus. J. Neuroimmunol. 46:121-126.
46. LOPEZ-GONZALEZ, M.A., J.M. GUERRERO, F. DELGADO (1997a) Presence of the pineal hormone melatonin in rat cochlea: Its variations with lighting conditions. Neurosci. Lett. 238:81-83.
47. LOPEZ-GONZALEZ, M.A., J.M. GUERRERO, B. SANCHEZ, F. DELGADO (1997b) Melatonin induces hyporeactivity caused by type II collagen in peripheral blood lymphocytes from patients with autoimmune hearing loss. Neurosci. Lett. 239:1-4.
48. LOPEZ-GONZALEZ, M.A., J.M. GUERRERO, B. SANCHEZ, F. DELGADO (1998a) Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis. Neurosci. Lett. 247:131-134.
49. LOPEZ-GONZALEZ, M.A., M. LUCAS, F. DELGADO, P. DIAZ (1998b) The production of free oxygen radicals and nitric oxide in the rat cochlea. Neurochem. Int. 33:55-59.
50. LOPEZ-GONZALEZ, M.A., J.M. GUERRERO, F. ROJAS, C. OSUNA, F. DELGADO (1999a) Melatonin and other antioxidants prolong the postmortem activity of the outer hair cells of the organ of Corti: Its relation to the type of death. J. Pineal Res. (In press).
51. LOPEZ-GONZALEZ, M.A., J.M. GUERRERO, R. TORRONTERAS, C. OSUNA, F. DELGADO (1999b) Ototoxicity caused by aminoglycosides is ameliorated by melatonin without interfering with the antibiotic capacity of the drugs. J. Pineal Res. (In press).
52. 125I-melatonin by rat thymus membranes during postnatal development. Immunol. Lett. 36:59-64.
53. 125I]-melatonin binding by rat thymus membranes: Effects of continuous light exposure and pinealectomy. Chronobiol. Int. 12:382-388.
54. MENENDEZ-PELAEZ, A., M.A. LOPEZ-GONZALEZ, J.M. GUERRERO (1993) Melatonin binding sites in the Harderian gland of Syrian hamsters: Sexual differences and effect of castration. J. Pineal Res. 14:34-38.
55. MEYSKENS, F.L., E.W. GERNER (1995) Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer. J. Cell Biochem. Suppl. 22:126-131.
56. MIETTINEN, S., G. LAURELL, A. ANDERSSON, R. JOHANSSON, E. LAURIKAINEN (1997) Blood flow-independent accumulation of cisplatin in the guinea pig cochlea. Acta Otolaryngol. (Stockh.) 117:55-60.
57. MORREY, K.M., J.A. MCLACHLAN, C.D. SERKIN, O. BAKOUCHE (1994) Activation of human monocytes by the pineal hormone melatonin. J. Immunol. 153:2671-2680.
58. NAKAGAWA, T., H. YAMANE, S. SHIBATA, Y. NAKAI (1997) Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs. Eur. Arch. Otorhinolaryngol. 254:9-14.
59. PLINKERT, P.K., S. KROBER (1991) Early detection of cisplatin-induced ototoxicity using evoked otoacoustic emissions. Laryngorhinootologie 70:457-462.
60. POZO, D., M. DELGADO, J.M. FERNANDEZ-SANTOS, J.R. CALVO, R.P. GOMARIZ, I. MARTIN-LACAVE, G.G. ORTIZ, J.M. GUERRERO (1997) Expression of the membrane melatonin receptor mRNA in T and B subsets of lymphocytes from rat thymus and spleen. FASEB J. 11:466-473.
61. PROBST, R., F.P. HARRIS, R. HAUSER (1993) Clinical monitoring using otoacoustic emissions. Br. J. Audiol. 27:85-90.
62. RAVI, R., S.M. SOMANI, L.P. RYBAK (1995) Mechanism of cisplatin ototoxicity: Antioxidant system. Pharmacol. Toxicol. 76:386-394.
63. REITER, R.J. (1980) The pineal gland and its hormones in the control of reproduction in mammals. Endocr. Rev. 1:109-131.
64. REITER, R.J. (1991) Pineal melatonin: Cell biology of its synthesis and of its physiological interactions. Endocr. Rev. 12:151-180.
65. REITER, R.J. (1995) Functional pleiotropy of the neurohormone melatonin: Antioxidant protection and neuroendocrine regulation. Front. Neuroendocrinol. 16:383-415.
66. REITER, R.J. (1996) The indoleamine melatonin as a free radical scavenger, electron donor, and antioxidant. In vitro and in vivo studies. Adv. Exp. Med. Biol. 398:307-313.
67. REITER, R.J., L. TANG, J.J. GARCIA, A. MUÑOZ-HOYOS (1997) Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci. 60:2255-2271.
68. REPPERT, S.M., D.R. WEAVER, S.A. RIVKEES, E.G. STOPA (1989) Putative melatonin receptors in a human biological clock. Science 242:78-81.
69. RYBAK, L.P., R. RAVI, S.M. SOMANI (1995) Mechanism of protection by diethyldihydrothiocarbamate against cisplatin ototoxicity: Antioxidant system. Fund. Appl. Toxicol. 26:293-300.
70. RYBAK, L.P., K. HUSAIN, L. EVENSON, C. MORRIS, C. WHITWORTH, S.M. SOMANI (1997) Protection by 4-methylthiobenzoic acid against cisplatin-induced ototoxicity: Antioxidant system. Pharmacol. Toxicol. 81:173-179.
71. SAITO, T., T. YAMADA, Y. MANABE, T. YAMAMOTO, H. SAITO (1996) Cisplatin metabolites and their toxicity on isolated cochlear outer hair cells in vitro. Acta Otolaryngol. (Stockh.) 116:561-565.
72. SAITO, T., Z.J. ZHANG, Y. MANABE, T. OHTSUBO, H. SAITO (1997) The effect of sodium thiosulfate on ototoxicity and pharmacokinetics after cisplatin treatment in guinea pigs. Eur. Arch. Otorhinolaryngol. 254:281-286.
73. SCHUCHTER, L.M. (1996) Exploration of platinum-based dose-intensive chemotherapy strategies with amifostine (Ethyol). Eur. J. Cancer 32A Suppl. 4:S40-42.
74. 2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin. Neurosci. Lett. 195:203-205.
75. SIE, K.C., S.J. NORTON (1997) Changes in otoacoustic emissions and auditory brain stem response after cis-platinum exposure in gerbils. Otolaryngol. Head Neck Surg. 116:585-592.
76. SMITH, D.W., J.P. ERRE, J.M. ARAN (1994) Rapid, reversible elimination of medial olivocochlear efferent function following single injections of gentamicin in the guinea pig. Brain Res. 652:243-248.
77. STENGS, C.H., S.F. KLIS, E.H. HUIZING, G.F. SMOORENBURG (1997) Cisplatin-induced ototoxicity: Electrophysiological evidence of spontaneous recovery in the albino guinea pig. Hearing Res. 111:103-113.
78. STYLES, L.A., E.P. VICHINSKY (1996) Ototoxicity in hemoglobinopathy patients chelayed with desferrioxiamine. J. Pediatr. Hematol. Oncol. 18:42-45.
79. TAN, D.X., L.D. CHEN, B. POEGGELER, L.C. MANCHESTER, R.J. REITER (1993) Melatonin: A potent endogenous hydroxyl radical scavenger. Endocr. J 1:57-60.
80. TANGE, R.A., W.A. DRESCHLER, F.A. CLAESSEN, R.M. PERENBOOM (1997) Ototoxic reactions of quinine in healthy persons and patients with Plasmodium falciparum infection. Auris Nasus Larynx 24:131-136.
81. VASQUEZ, E.M., M.S. MADDUX, J. SANCHEZ, R. POLLAK (1993) Clinically significant hearing loss in renal allograft recipients treated with intravenous erythromycin. Arch. Intern. Med. 153:879-882.
82. ZDANSKI, C.J., J. PRAZMA, P. PETRUSZ, G. GROSSMAN, E. RAYNOR, T.L. SMITH, H.C. PILLSBURY (1994) Nitric oxide synthase is an active enzyme in the spiral ganglion cells of the rat cochlea. Hearing Res. 79:3947.
83. ZOROWKA, P.G., H.J. SCHMITT, P. GUTJAHR (1993) Evoked otoacoustic emissions and pure tone threshold audiometry in patients receiving cisplatinum therapy. Int. J. Pediatr. Otorhinolaryngol. 25:73-80.