Melatonin and the Circadian Regulation of Sleep Initiation, Consolidation, Structure, and the Sleep EEG

Journal of Biological Rhythms

Volumn 12, Issue 6, 1997, Pages 627-635

  Dijk, Derk Jan ^a   Cajochen, Christian ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

EEG; Hypnotics; REM sleep; Sleep spindles; Slow wave sleep; Suprachiasmatic nucleus

Indexed keywords

MELATONIN;

ANIMAL; CIRCADIAN RHYTHM; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; HUMAN; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER; PHYSIOLOGY; REVIEW; SLEEP;

NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER;

ANIMALS; CIRCADIAN RHYTHM; ELECTROENCEPHALOGRAPHY; HUMANS; MELATONIN; SLEEP;

EID: 0031304820     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: 10.1177/074873049701200618     Document Type: Article

References (26)

1. Cagnacci A, Kräuchi K, Wirz-Justice A, and Volpe A (1997) Homeostatic versus circadian effects of melatonin on core body temperature in humans. J Biol Rhythms 12:509-517.
2. Cajochen C, Kräuchi K, Möri D, Graw P, and Wirz-Justice A (1997) Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis. Am J Physiol 272:R1189-R1196.
3. Cajochen C, Kräuchi K, von Arx MA, Möri D, Graw P, and Wirz-Justice A (1996) Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG. Neurosci Lett 207:209-213.
4. Deacon S and Arendt J (1995) Melatonin-induced temperature suppression and its acute phase-shifting effects correlate in a dose-dependent manner in humans. Brain Res 688:77-85.
5. Dijk D-J, Beersma DGM, Daan S, and Lewy AJ (1989) Bright morning light advances the human circadian system without affecting NREM sleep homeostasis. Am J Physiol 256:R106-R111.
6. Dijk D-J and Czeisler CA (1994) Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neurosci Lett 166:63-68.
7. Dijk D-J and Czeisler CA (1995) Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves and sleep spindle activity in humans. J Neurosci 15:3526-3538.
8. Dijk D-J, Roth C, Landolt HP, Werth E, Aeppli M, Achermann P, and Borbély AA (1995a) Melatonin effect on daytime sleep in men: Suppression of EEG low frequency activity and enhancement of spindle frequency activity. Neurosci Lett 201:13-16.
9. Dijk D-J, Shanahan TL, Duffy JF, Ronda JM, and Czeisler CA (1995b) Melatonin, sleep consolidation, body temperature, slow-wave and sleep spindle activity: Phase relations of their circadian rhythms during forced desynchrony. Sleep Res 24A:162.
10. Dijk D-J, Shanahan TL, Duffy JF, Ronda JM, and Czeisler CA (in press). Variation of electroencephalographic activity during non-REM and REM sleep with phase of circadian melatonin rhythm in humans. J Physiol (London).
11. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, and Deng MH (1994) Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 91:1824-1828.
12. Duffy JF, Dijk D-J, Klerman EB, and Czeisler CA (1997) Altered phase relationship between body temperature cycle and habitual awakening in older subjects. Sleep Res 26:711.
13. Hughes RJ and Badia P (1997) Sleep-promoting and hypothermic effects of daytime melatonin administration in humans. Sleep 20:124-131.
14. Kräuchi K and Wirz-Justice A (1994) Circadian rhythm of heat production, heart rate and skin and core temperature under unmasking conditions in men. Am J Physiol 267:819-829.
15. Lack LC and Lushington K (1996) The rhythms of human sleep propensity and core body temperature. J Sleep Res 5:1-11.
16. Lavie P (1986) Ultrashort sleep-waking schedule: III. "Gates" and "forbidden zones" for sleep. Electroenceph Clin Neurophysiol 63:414-425.
17. Lavie P (1997) Melatonin: Role in gating nocturnal rise in sleep propensity. J Biol Rhythms 12:657-665.
18. Lockley SW, Skene DJ, Tabandeh H, Bird AC, Defrance R, and Arendt J (1997) Relationship between napping and melatonin in the blind. J Biol Rhythms 12:16-25.
19. McArthur AJ, Lewy AJ, and Sack RL (1996) Non-24-hour sleep-wake syndrome in a sighted man: Circadian rhythm studies and efficacy of melatonin treatment. Sleep 19:544-553.
20. Middleton BA, Stone BM, and Arendt J (1996) Melatonin and fragmented sleep patterns. Lancet 348:551-552.
21. Nakagawa H, Sack RL, and Lewy AJ (1992) Sleep propensity free-runs with the temperature, melatonin, and cortisol rhythms in a totally blind person. Sleep 15:330-336.
22. Nave R, Herer P, Haimov I, Shlitner A, and Lavie P (1996) Hypnotic and hypothermic effects of melatonin on daytime sleep in humans: Lack of antagonism by flumazenil. Neurosci Lett 214:123-126.
23. Reid K, VandenHeuvel C, and Dawson D (1996) Day-time melatonin administration: Effects on core temperature and sleep onset latency. J Sleep Res 5:150-154.
24. Tzischinsky O and Lavie P (1994) Melatonin possesses time-dependent hypnotic effects. Sleep 17:638-645.
25. Tzischinsky O, Shlitner A, and Lavie P (1993) The association between the nocturnal sleep gate and nocturnal onset of urinary 6-sulfatoxymelatonin. J Biol Rhythms 8:199-209.
26. Zhdanova IV, Wurtman RJ, Morabito C, Piotrovska VR, and Lynch HJ (1996) Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep 19:423-431.