The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats

Journal of Pineal Research

Volumn 32, Issue 1, 2002, Pages 21-25

  Arslan, Seyfullah O ^a   Zerin, Mustafa ^b   Vural, Huseyin ^b   Coskun, Ali ^b  

^a ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

^b HARRAN UNIVERSITY   (Turkey)

Author keywords

Antioxidant defense enzymes; Bleomycin; Bronchoalveolar lavage fluid; Fibrosis; Lipid peroxidation; Melatonin; Rat

Indexed keywords

BIOLOGICAL MARKER; BLEOMYCIN; CATALASE; GLUTATHIONE PEROXIDASE; HYDROXYPROLINE; LACTATE DEHYDROGENASE; MELATONIN; PROTEIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; LIPID PEROXIDATION; LUNG FIBROSIS; LUNG HOMOGENATE; LUNG LAVAGE; LUNG PROTECTION; LUNG TOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTECTION; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; BLEOMYCIN; FEMALE; LIPID PEROXIDATION; LUNG; MELATONIN; OXIDATIVE STRESS; PULMONARY FIBROSIS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 0036164087     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079x.2002.10796.x     Document Type: Article

References (50)

1. Plasma glutathione and glutathione disulfide in the rat: Regulation and response to oxidative stress
2. Protective effect of melatonin on indomethacin-induced gastric injury in rats
3. Antioxidant and pro-oxidant properties of active rosemary constituents: Carnosol and carnosic acid
4. Characterization of antioxidant effects of melatonin and related indoleamines in vitro
5. Bleomycin: A review
6. Melatonin suppresses the pinealectomy-induced elevation of collagen content in a wound
7. Pinealectomy-induced elevation of collagen content in the intact skin is suppressed by melatonin application
8. Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock' induced by zymosan
9. Changes in distribution, morphology, and tumor necrosis factor-alpha secration of alveolar macrophage subpopulations during the development of bleomycin-induced pulmonary fibrosis
10. Alterations in pulmonary protective enzymes following systemic bleomycin treatment in mice
11. Effects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lung of hamsters
12. Effects of beta-carotene and alpha-tocopherol on bleomycin-induced chromosomal damage
13. Tissue changes in glutathione metabolism and lipid peroxidation induced by swimming are partially prevented by melatonin
14. Inhibitory effects of the dietary antioxidants butylated hydroxyanisole and butylated hydroxytoluene on bronchioloalveolar cell proliferation during the bleomycin-induced pulmonary fibrosing process in hamsters
15. Antioxidant activity in alveolar epithelial type 2 cells of rats during the development of bleomycin injury
16. Cell proliferation during the process of bleomycin-induced pulmonary fibrosis in rats
17. Comparative effect of melatonin, 1-Deprenyl, Trolox and ascorbate in the suppression of hydroxyl radical formation during dopamine autoxidation in vitro
18. Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat
19. Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA
20. Protective effect of liposome-entrapped superoxide dismutase and catalase on bleomycin-induced lung injury in rats. I. Antioxidant enzyme activities and lipid peroxidation
21. Cataractogenesis and lipid peroxidation in newborn rats treated with buthionine sulfoximine: Preventive actions of melatonin
22. Effect of pineal indoles on activities of the antioxidant defense enzymes superoxide dismutase, catalase, and glutathione reductase, and levels of reduced and oxidized glutathione in rat tissues
23. Protein measurement with the Folin phenol reagent
24. Evaluation of the antioxidant activity of melatonin in vitro
25. Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats
26. Protective role of metatonin and retinol palmitate in oxidative stress and hyperlipidemic nephropathy induced by adriamycin in rats
27. Oxidative stress in diabetic rats induced by streptozotocin: Protective effects of melatonin
28. Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats
29. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
30. Preventive effect of melatonin on the progression of carbon tetrachloride-induced acute liver injury in rats
31. Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin
32. Time course of the melatonin-induced increase in glutathione peroxidase activity in chick tissues
33. Comparison of the antioxidant activity of melatonin and pinoline in vitro
34. Regulation of antioxidant enzymes in lung after oxidant injury
35. Glutathione redox system in oxidative lung injury
36. Melatonin: Mechanisms and actions as an antioxidant
37. Pharmacological actions of melatonin in oxygen radical pathophysiology
38. Bleomycin stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activities
39. Evaluation of the antioxidant actions of ferulic acid and catechins
40. Melatonin reduces both basal and bacterial lipopolysaccharide-induced lipid peroxidation in vitro
41. The efficacy of vitamin E and melatonin as antioxidants against lipid peroxidation in rat retinal homogenates
42. Bleomycin primes monocytes-macrophages for suproxide production
43. Melatonin: A potent, endogenous hydroxyl radical scavenger
44. Both physiological and pharmacological levels of melatonin reduces DNA adduct formation induced by the carcinogen safrole
45. Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: Prevention by melatonin
46. Melatonin directly scavenges hydrogen peroxide: A potentially new metabolic patway of melatonin biotransformation
47. Curcumin protects bleomycin-induced lung injury in rats
48. Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats
49. Endogenous glutathione conjugates: Occurrence and biological functions
50. The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid