Inhibitory action of melatonin on H2O2- and cyclophosphamide-induced DNA damage

Mutagenesis

Volumn 14, Issue 1, 1999, Pages 107-112

  De Salvia, R ^a   Fiore, M ^a   Aglitti, T ^b   Festa, F ^b   Ricordy, R ^a   Cozzi, R ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CYCLOPHOSPHAMIDE; DNA; FREE RADICAL; HYDROGEN PEROXIDE; MELATONIN; OXYGEN; PINEAL BODY HORMONE; SCAVENGER;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CHROMOSOME ABERRATION; CYTOFLUOROMETRY; CYTOGENETICS; DNA DAMAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SISTER CHROMATID EXCHANGE;

ANIMALS; CELL DIVISION; CELLS, CULTURED; CHO CELLS; CHROMOSOMES; CRICETINAE; CYCLOPHOSPHAMIDE; DNA DAMAGE; HYDROGEN PEROXIDE; MELATONIN;

ANIMALIA; MAMMALIA;

EID: 0032935683     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/14.1.107     Document Type: Article

References (34)

1. Anisimov, V.N., Popovich, I.G. and Zabenzhinski, M.A. (1997) Melatonin and colon carcinogenesis: I. Inihitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylydrazine in rats. Carcinogenesis, 18, 1549-1553
2. Blask, D. (1993) Melatonin in oncology. In Yu, H.S. and Reiter, R.J. (eds), Melatonin. CRC Press, Boca Raton, FL, pp. 447-475.
3. Brzezinski, A. (1997) Melatonin in humans. New Engl. J. Med., 336, 186-195.
4. Clayson, D.B., Mehta, R. and Iverson, F. (1994) Oxidative DNA damage. The effects of certain genotoxic and operationally non-genotoxic carcinogens. Mutat. Res., 317, 25-42.
5. Cos, S., Blask, D.E., Lemus-Wilson, A. and Hill, A.B. (1991) Effects of melatonin on the cell cycle kinetics and 'estrogen-rescue' of MCF-7 human breast cancer cells in culture. J. Pineal Res., 10, 36-41.
6. Cos, S., Recio, J. and Sanchez-Barcelo, E.J. (1996) Modulation of the lenght of cell cycle time of MCF-7 human breast cancer cells hy melatonin. Life Sci., 58, 811-816.
7. Cozzi, R., Bona, R., Polani, S. and De Salvia, R. (1989) Retinoids as modulators of metabolism: their inhibitory effect on CP and 7.12-DMBA induced SCEs in a metabolically competent cell line. Mutagenesis, 5, 397-401.
8. Cozzi, R., Ricordy, R., Bartolini, F., Ramadori, L., Perticone, P. and De Salvia, R. (1995) Taurine and ellagic acid: two differently-acting natural antioxidants. Enviiron. Mol. Mutagen., 26, 248-254.
9. Cozzi, R., Ricordy, R., Aglilti, T., Gatta, V., Perticone, P. and De Salvia, R. (1997) Ascorbic acid and β-carotene as modulators of oxidative damage. Carcinogenesis, 18, 223-228.
10. Hengstler, J.G., Hengst, A., Fuchs, J., Tanner, B., Pohl, J. and Oesch, F. (1997) Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after inactivation by cytochrome P-450 2B1. Mutat. Res., 373, 215-223.
11. Hill, S.M. and Blask, D.E. (1988) Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res., 48, 6121-6126.
12. Ianas, O., Olinescu, R. and Badescu, I. (1991) Melatonin involvement in oxidative processes. Endocrinologie, 29, 147-153.
13. Kothari, L.S. and Subramanian, A. (1992) A possible modulatory influence of melatonin on representative phase I and II drug metabolizing enzymes in 9,10-dimethyl-1,2-benzanthracene induced rat mammary tumorigenesis. Anti-Cancer Drugs, 3, 623-628.
14. Le Blanc, G.A. and Waxman, D.J. (1990) Mechanisms of cyclophosphamide action on hepatic P-450 expression. Cancer Res., 50, 5720-5726.
15. Maestroni, G.J. (1993) The immunoneuroendocrine role of melatonin. J. Pineal Res., 14. 1-10.
16. Marshall, K.A., Reiter, R.J., Poeggeler, B., Aruoma, O.I. and Halliwell, B. (1996) Evaluation of the antioxidant activity of melatonin in vitro. Free Radical Biol. Med., 21, 307-315.
17. Oya, Y. Yamamoto, K. and Tonumura, A. (1986) The biological activity of hydrogen peroxide. Induction of chromosome-type aberrations susceptible to inhibition by scavengers of hydroxyl radicals in embryonic fibroblasts. Mutat. Res., 172, 245-253.
18. Pablos, M.I., Chuang, J.I., Reiter, R., Ortiz, G.G., Daniels, W.M.U., Sewerynek, E., Melchiorri, D. and Poeggeler, B. (1995) Time course of melatonin-induced increase in glutathione peroxidase activity in chick tissues. Biol. Signals, 4, 325-330.
19. Palitti, F., Fiore, M., De Salvia, R., Tanzarella, C. Ricordy, R., Forster, R., Mosesso, P., Astolfi, S. and Loprieno, N. (1985) Tests for the valuation of chromosomal aberrations in Chinese Hamster Ovary (CHO) cells in culture. In Ashby, J. et al. (eds), Progress in Mutation Research. Elsevier Science, Amsterdam, The Netherlands, Vol. 5, pp. 443-450.
20. Persengiev, S.P. and Kyurkchiev, S. (1993) Selective effect of melatonin on the proliferation of lymphoid cells. Int. J. Biochem., 25, 441-444.
21. Praast, G., Bartsch, C., Bartsch, H., Mecke, D. and Lippert, T.H. (1995) Hepatic hydroxylation of melatonin in the rats is induced by phenobarbital and 7.12-dimethylbenz(α)anthracene - implications for cancer etiology. Experientia, 51, 349-355.
22. Pryor, W. (1976) In Pryor, W. (ed.), Free Radicals in Biology. Academic Press, New York, NY, Vol. 1.
23. Reiter, R.J., Regina, C., Carneiro, C. and Oh, S. (1997) Melatonin in relation to cellular antioxidative defense mechanisms. Hormone Metab. Res., 29, 363-372.
24. Ren, S., Yang, J.S., Kalhorn, T.F. and Slattery, J.T. (1997) Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethyl-cyclophosphamide in human liver microsomes. Cancer Res., 57, 4229-4235.
25. 60Co gamma-radiation. Mutat. Res., 289, 197-204.
26. Sanderson, B.J. and Shield, A.J. (1996) Mutagenic damage to mammalian cells by therapeutic alkylating agents. Mutat. Res., 355, 41-57.
27. Shamberger, R.J. (1984) Genetic toxicology of ascorbic acid. Mutat. Res., 133, 135-159.
28. Sies, H., Stahl, W. and Sundquist, A.R. (1992) Antioxidant functions of vitamins: vitamins E and B, β-carotene and other carotenoids. Annls NY Acad. Sci., 669, 7-20.
29. Sturelid, S. and Kihlman, B.A. (1978) The temperature and time functions in caffeine potentiation of chemically induced chromosomal aberrations in root typs of Vicia faba. Hereditas, 88, 27-33.
30. Tan, D.X., Chen, L.D., Poeggeler, B., Manchester and Reiter, R.J. (1993) Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr. J., 1, 57-60.
31. Tan, D.X., Reiter, R.J., Chen, L.D., Poeggeler, B., Manchester, L.C. and Barlow-Walden, L.R. (1994) Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole. Carcinogenesis, 15, 215-218.
32. Vijayalaxmi, Reiter, R.J., Sewerinek, E., Poeggeler, B., Leal, B.Z. and Meltz, M.L. (1995) Marked reduction of radiation-induced micronuclei in human blood lymphocytes pretreated with melatonin. Radiat. Res., 143, 102-106.
33. Vijayalaxmi, Reiter, R.J., Herman, T.S. and Meltz, M.L. (1996) Melatonin and radioprotection from genetic damage: in vivolin vitro studies with human volunters. Mutat. Res., 371, 221-228.
34. Witt-Enderby, P.A. and Dubocovich, M.L. (1996) Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells. Mol. Pharmacol., 50, 166-174.