Melatonin directly scavenges hydrogen peroxide: A potentially new metabolic pathway of melatonin biotransformation

Free Radical Biology and Medicine

Volumn 29, Issue 11, 2000, Pages 1177-1185

  Tan, Dun Xian ^a   Manchester, Lucien C ^a   Reiter, Russel J ^a   Plummer, Benjamin F ^b   Limson, Janice ^a   Weintraub, Susan T ^c   Qi, Wenbo ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b TRINITY UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

AFMK; AMK; Catalase; Free radical; Hydrogen peroxide; Melatonin; N1 acetyl 5 methoxykynuramine; N1 acetyl N2 formyl 5 methoxykynuramine; N1 acetyl N2 formyl 5 methoxykynuramine

Indexed keywords

HYDROGEN PEROXIDE; KYNURAMINE; MELATONIN; N1 ACETYL 5 METHOXYKYNURAMINE; N1 ACETYL N2 FORMYL 5 METHOXYKYNURAMINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; PRIORITY JOURNAL; REACTION ANALYSIS; SCAVENGING SYSTEM; SPECTROPHOTOMETRY;

CATALASE; FREE RADICAL SCAVENGERS; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; KINETICS; KYNURAMINE; MAGNETIC RESONANCE SPECTROSCOPY; MELATONIN;

EID: 0034564392     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00435-4     Document Type: Article

References (40)

1. Melatonin immunoreactivity in the photosynthetic prokaryote, Rhodospirillum rubrum; implications for an ancient antioxidant system
2. Pineal hormone melatonin oscillates also in the dinoflagellate
3. Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates
4. Pineal melatonin; cell biology of its synthesis and its physiological interactions
5. Detection of melatonin, its precursor and related enzyme activities in rabbit lens
6. N-acetyltransferase activity, hydroxyindole-O-methyltransferase activity, and melatonin levels in the Harderian glands of the female Syrian hamster; changes during the light: dark cycle and the effects of 6-chlorophenylalanine administration
7. Detection of melatonin and serotonin N-acetyltransferase and hydroxyindole-O-methyltransferase in rat ovary
8. Melatonin in the rat testis; evidence for local synthesis
9. Identification of highly elevated levels of melatonin in bone marrow; its origin and significance
10. Evidence for melatonin synthesis in mouse and human bone marrow cells
11. Melatonin; the chemical expression of darkness
12. Melatonin; a potent, endogenous hydroxyl radical scavenger
13. Oxidative damage in the central nervous system; protection by melatonin
14. The oxidant/antioxidant network; role of melatonin
15. On the primary functions of melatonin in evolution; mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals
16. Oxygen toxicity, oxygen free radicals, transition metals and disease
17. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture
18. Scavenging of reactive oxygen species by melatonin
19. Reaction of the superoxide radical with the N-centered radical derived from N-acetyltryptophan methyl ester
20. In vitro and in vivo formation of two new metabolites of melatonin
21. N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis
22. Inhibition of diazepam binding by tryptophan derivatives including melatonin and its brain metabolite N-acetyl-5-methoxy kynurenamine
23. The significance of the metabolism of the neurohormone melatonin; antioxidative protection and formation of bioactive substances
24. Hydroperoxide metabolism in mammalian organs
25. High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus
26. Nuclear localization of melatonin in different mammalian tissues; immunocytochemical and radioimmunoassay evidence
27. Antioxidative protection in a high-melatonin organism; the dinoflagellate Gonyaulax polyedra is reduced from lethal oxidative stress by strongly elevated, but physiologically possible concentrations of melatonin
28. Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole
29. Alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice
30. Alzheimer beta protein mediated oxidative damage of mitochondrial DNA; prevention by melatonin
31. 2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors
32. Adriamycin stimulated superoxide formation in submitochondrial particles
33. Ischemia/reperfusion-induced arrhythmias in the isolated rat heart; prevention by melatonin
34. Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen
35. Melatonin protects against ischemia and reperfusion-induced oxidative lipid and DNA damage in fetal rat brain