-
1
-
-
0036134022
-
The clinicopathologic spectrum and management of nonalcoholic fatty liver disease
-
Contos M J Sanyal A J The clinicopathologic spectrum and management of nonalcoholic fatty liver disease Advances in Anatomy and Pathology 9 2002 37-51
-
(2002)
Advances in Anatomy and Pathology
, vol.9
, pp. 37-51
-
-
Contos, M.J.1
Sanyal, A.J.2
-
3
-
-
0033982172
-
Prevalence of and risk factors for hepatic steatosis in Northern Italy
-
Bellentani S Saccoccio G Masutti F et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy Annals of Internal Medicine 132 2000 112-117
-
(2000)
Annals of Internal Medicine
, vol.132
, pp. 112-117
-
-
Bellentani, S.1
Saccoccio, G.2
Masutti, F.3
-
4
-
-
0035084699
-
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
-
Sanyal A J Campbell-Sargent C Mirshahi F et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183-1192
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
-
5
-
-
0019152816
-
Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
-
Ludwig J Viggiano T R McGill D B Oh B J Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease Mayo Clinic Proceedings 55 1980 434-438
-
(1980)
Mayo Clinic Proceedings
, vol.55
, pp. 434-438
-
-
Ludwig, J.1
Viggiano, T.R.2
McGill, D.B.3
Oh, B.J.4
-
6
-
-
0025178612
-
The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
-
Powell E E Cooksley W G Hanson R et al. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years Hepatology 11 1990 74-80
-
(1990)
Hepatology
, vol.11
, pp. 74-80
-
-
Powell, E.E.1
Cooksley, W.G.2
Hanson, R.3
-
7
-
-
0025260531
-
Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
-
Wanless I R Lentz J S Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors Hepatology 12 1990 1106-1110
-
(1990)
Hepatology
, vol.12
, pp. 1106-1110
-
-
Wanless, I.R.1
Lentz, J.S.2
-
8
-
-
0021343433
-
Prevalence of fatty liver in healthy adults accidentally killed
-
Ground K EV Prevalence of fatty liver in healthy adults accidentally killed Aviation, Space and Environmental Medicine 55 1984 59-61
-
(1984)
Aviation, Space and Environmental Medicine
, vol.55
, pp. 59-61
-
-
Ground, K.E.V.1
-
9
-
-
0034659943
-
Selection and outcome of living donors for adult to adult right lobe transplantation
-
Marcos A Fisher R A Ham J M et al. Selection and outcome of living donors for adult to adult right lobe transplantation Transplantation 69 2000 2410-2415
-
(2000)
Transplantation
, vol.69
, pp. 2410-2415
-
-
Marcos, A.1
Fisher, R.A.2
Ham, J.M.3
-
11
-
-
0033583977
-
Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: A cohort study
-
Carr A Samaras K Thorisdottir A et al. Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study Lancet 353 1999 2093-2099
-
(1999)
Lancet
, vol.353
, pp. 2093-2099
-
-
Carr, A.1
Samaras, K.2
Thorisdottir, A.3
-
12
-
-
0033758597
-
Lipodystrophy following antiretroviral therapy of primary HIV infection
-
Miller J Carr A Smith D et al. Lipodystrophy following antiretroviral therapy of primary HIV infection AIDS 14 2000 2406-2407
-
(2000)
AIDS
, vol.14
, pp. 2406-2407
-
-
Miller, J.1
Carr, A.2
Smith, D.3
-
14
-
-
0028106034
-
Role of free radicals in liver diseases and hepatic fibrosis
-
Britton R S Bacon B R Role of free radicals in liver diseases and hepatic fibrosis Hepatogastroenterology 41 1994 343-348
-
(1994)
Hepatogastroenterology
, vol.41
, pp. 343-348
-
-
Britton, R.S.1
Bacon, B.R.2
-
15
-
-
0031921972
-
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes
-
Berson A De B V Letteron P et al. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes Gastroenterology 114 1998 764-774
-
(1998)
Gastroenterology
, vol.114
, pp. 764-774
-
-
Berson, A.1
De, B.V.2
Letteron, P.3
-
16
-
-
0031962151
-
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
-
Weltman M D Farrell G C Hall P et al. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis Hepatology 27 1998 128-133
-
(1998)
Hepatology
, vol.27
, pp. 128-133
-
-
Weltman, M.D.1
Farrell, G.C.2
Hall, P.3
-
17
-
-
0034092716
-
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
-
Leclercq I A Farrell G C Field J et al. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis Journal of Clinical Investigation 105 2000 1067-1075
-
(2000)
Journal of Clinical Investigation
, vol.105
, pp. 1067-1075
-
-
Leclercq, I.A.1
Farrell, G.C.2
Field, J.3
-
18
-
-
0035082455
-
Peroxisomal beta-oxidation and steatohepatitis
-
Rao M S Reddy J K Peroxisomal beta-oxidation and steatohepatitis Seminars in Liver Disease 21 2001 43-55
-
(2001)
Seminars in Liver Disease
, vol.21
, pp. 43-55
-
-
Rao, M.S.1
Reddy, J.K.2
-
19
-
-
0034127757
-
Cytokine regulation of liver injury and repair
-
Diehl A M Cytokine regulation of liver injury and repair Immunological Reviews 174 2000 160-171
-
(2000)
Immunological Reviews
, vol.174
, pp. 160-171
-
-
Diehl, A.M.1
-
20
-
-
50249216083
-
Diabetes mellitus: A differentiation into insulin-sensitive and insulin-insensitive subtypes
-
Himsworth H Diabetes mellitus: a differentiation into insulin-sensitive and insulin-insensitive subtypes Lancet i 1936 127-130
-
(1936)
Lancet
, vol.1
, pp. 127-130
-
-
Himsworth, H.1
-
21
-
-
0024160877
-
Banting Lecture 1988. Role of insulin resistance in human disease 1988
-
Reaven G M Banting Lecture 1988. Role of insulin resistance in human disease 1988 Diabetes 37 1988 1595-1607
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
24
-
-
85047682715
-
Minireview: Tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology
-
Butler A A LeRoith D Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology Endocrinology 142 2001 1685-1688
-
(2001)
Endocrinology
, vol.142
, pp. 1685-1688
-
-
Butler, A.A.1
LeRoith, D.2
-
25
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel A R Kahn C R Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 2001 799-806
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
26
-
-
0042570843
-
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
-
Virkamaki A Ueki K Kahn C R Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance Journal of Clinical Investigation 103 1999 931-943
-
(1999)
Journal of Clinical Investigation
, vol.103
, pp. 931-943
-
-
Virkamaki, A.1
Ueki, K.2
Kahn, C.R.3
-
28
-
-
0033913213
-
Signaling pathways in insulin action: Molecular targets of insulin resistance
-
Pessin J E Saltiel A R Signaling pathways in insulin action: molecular targets of insulin resistance Journal of Clinical Investigation 106 2000 165-169
-
(2000)
Journal of Clinical Investigation
, vol.106
, pp. 165-169
-
-
Pessin, J.E.1
Saltiel, A.R.2
-
29
-
-
0030810216
-
Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
-
Standaert M L Galloway L Karnam P et al. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport Journal of Biological Chemistry 272 1997 30075-30082
-
(1997)
Journal of Biological Chemistry
, vol.272
, pp. 30075-30082
-
-
Standaert, M.L.1
Galloway, L.2
Karnam, P.3
-
30
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi D R James S R Downes C P et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Curr Biol 7(4) 1997 261-269
-
(1997)
Curr Biol
, vol.7
, Issue.4
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
-
31
-
-
0025823448
-
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
-
Boulton T G Nye S H Robbins D J et al. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF Cell 65(4) 1991 663-675
-
(1991)
Cell
, vol.65
, Issue.4
, pp. 663-675
-
-
Boulton, T.G.1
Nye, S.H.2
Robbins, D.J.3
-
32
-
-
0034648794
-
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
-
Baumann C A Ribon V Kanzaki M et al. CAP defines a second signalling pathway required for insulin-stimulated glucose transport Nature 407 2000 202-207
-
(2000)
Nature
, vol.407
, pp. 202-207
-
-
Baumann, C.A.1
Ribon, V.2
Kanzaki, M.3
-
33
-
-
0035912228
-
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10
-
Chiang S H Baumann C A Kanzaki M et al. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10 Nature 410 2001 944-948
-
(2001)
Nature
, vol.410
, pp. 944-948
-
-
Chiang, S.H.1
Baumann, C.A.2
Kanzaki, M.3
-
34
-
-
0035921433
-
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation
-
Watson R T Shigematsu S Chiang S H et al. Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation Journal of Cell Biology 154 2001 829-840
-
(2001)
Journal of Cell Biology
, vol.154
, pp. 829-840
-
-
Watson, R.T.1
Shigematsu, S.2
Chiang, S.H.3
-
35
-
-
0035834771
-
Transcriptional regulation of the human sterol 12α-hydroxylase gene (CYP8B1): Roles of hepatocyte nuclear factor 4α in mediating bile acid repression
-
Zhang M Chiang J Y Transcriptional regulation of the human sterol 12α-hydroxylase gene (CYP8B1): roles of hepatocyte nuclear factor 4α in mediating bile acid repression Journal of Biological Chemistry 276 2001 41690-41699
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 41690-41699
-
-
Zhang, M.1
Chiang, J.Y.2
-
37
-
-
0033522897
-
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
-
Nakae J Park B C Accili D Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway Journal of Biological Chemistry 274 1999 15982-15985
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 15982-15985
-
-
Nakae, J.1
Park, B.C.2
Accili, D.3
-
38
-
-
0034804783
-
Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes
-
Shimano H Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes Progress in Lipid Research 40 2001 439-452
-
(2001)
Progress in Lipid Research
, vol.40
, pp. 439-452
-
-
Shimano, H.1
-
39
-
-
0033636780
-
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
-
Shimomura I Matsuda M Hammer R E et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice Molecular Cell 6 2000 77-86
-
(2000)
Molecular Cell
, vol.6
, pp. 77-86
-
-
Shimomura, I.1
Matsuda, M.2
Hammer, R.E.3
-
40
-
-
0031602585
-
Regulation of insulin action by protein tyrosine phosphatases
-
Goldstein B J Li P M Ding W et al. Regulation of insulin action by protein tyrosine phosphatases Vitamins and Hormones 54 1998 67-96
-
(1998)
Vitamins and Hormones
, vol.54
, pp. 67-96
-
-
Goldstein, B.J.1
Li, P.M.2
Ding, W.3
-
41
-
-
2642614548
-
Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
-
Anthonsen M W Ronnstrand L Wernstedt C et al. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro Journal of Biological Chemistry 273 1998 215-221
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 215-221
-
-
Anthonsen, M.W.1
Ronnstrand, L.2
Wernstedt, C.3
-
42
-
-
0033664155
-
Organizing glucose disposal: Emerging roles of the glycogen targeting subunits of protein phosphatase-1
-
Newgard C B Brady M J O'Doherty R M Saltiel A R Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1 Diabetes 49 2000 1967-1977
-
(2000)
Diabetes
, vol.49
, pp. 1967-1977
-
-
Newgard, C.B.1
Brady, M.J.2
O'Doherty, R.M.3
Saltiel, A.R.4
-
43
-
-
0030721534
-
The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action
-
Brady M J Nairn A C Saltiel A R The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action Journal of Biological Chemistry 272 1997 29698-29703
-
(1997)
Journal of Biological Chemistry
, vol.272
, pp. 29698-29703
-
-
Brady, M.J.1
Nairn, A.C.2
Saltiel, A.R.3
-
44
-
-
0026520193
-
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis
-
Pilkis S J Granner D K Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis Annual Review of Physiology 54 1992 885-909
-
(1992)
Annual Review of Physiology
, vol.54
, pp. 885-909
-
-
Pilkis, S.J.1
Granner, D.K.2
-
45
-
-
0022459321
-
Insulin decreases H4IIE cell PEPCK mRNA by a mechanism that does not involve cAMP
-
Beale E G Koch S R Brotherton A F et al. Insulin decreases H4IIE cell PEPCK mRNA by a mechanism that does not involve cAMP Diabetes 35 1986 546-549
-
(1986)
Diabetes
, vol.35
, pp. 546-549
-
-
Beale, E.G.1
Koch, S.R.2
Brotherton, A.F.3
-
48
-
-
0032766006
-
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt
-
Kitamura T Kitamura Y Kuroda S et al. Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt Molecular and Cellular Biology 19 1999 6286-6296
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 6286-6296
-
-
Kitamura, T.1
Kitamura, Y.2
Kuroda, S.3
-
49
-
-
0034057796
-
Mechanisms of protein degradation: What do the rat studies tell us
-
Bailey J L Mitch W E Mechanisms of protein degradation: what do the rat studies tell us Journal of Nephrology 13 2000 89-95
-
(2000)
Journal of Nephrology
, vol.13
, pp. 89-95
-
-
Bailey, J.L.1
Mitch, W.E.2
-
50
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki E Lipes M A Patti M E et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene Nature 372 1994 186-190
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
-
51
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
-
Griffin M E Marcucci M J Cline G W et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade Diabetes 48 1999 1270-1274
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
-
52
-
-
0032954778
-
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
-
Dresner A Laurent D Marcucci M et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity Journal of Clinical Investigation 103 1999 253-259
-
(1999)
Journal of Clinical Investigation
, vol.103
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Marcucci, M.3
-
53
-
-
0019762341
-
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
-
DeFronzo R A Jacot E Jequier E et al. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization Diabetes 30 1981 1000-1007
-
(1981)
Diabetes
, vol.30
, pp. 1000-1007
-
-
DeFronzo, R.A.1
Jacot, E.2
Jequier, E.3
-
54
-
-
0021994683
-
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
-
DeFronzo R A Gunnarsson R Bjorkman O et al. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus Journal of Clinical Investigation 76 1985 149-155
-
(1985)
Journal of Clinical Investigation
, vol.76
, pp. 149-155
-
-
DeFronzo, R.A.1
Gunnarsson, R.2
Bjorkman, O.3
-
55
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
Steppan C M Bailey S T Bhat S et al. The hormone resistin links obesity to diabetes Nature 409 2001 307-312
-
(2001)
Nature
, vol.409
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
-
57
-
-
0033393956
-
The role of TNF-alpha in human adipose tissue: Prevention of weight gain at the expense of insulin resistance?
-
Hube F Hauner H The role of TNF-alpha in human adipose tissue: prevention of weight gain at the expense of insulin resistance? Hormone and Metabolic Research 31 1999 626-631
-
(1999)
Hormone and Metabolic Research
, vol.31
, pp. 626-631
-
-
Hube, F.1
Hauner, H.2
-
58
-
-
0033835211
-
Leptin - Much more than a satiety signal
-
Harris R B Leptin - much more than a satiety signal Annual Review of Nutrition 20 2000 45-75
-
(2000)
Annual Review of Nutrition
, vol.20
, pp. 45-75
-
-
Harris, R.B.1
-
62
-
-
0028342686
-
Mechanisms of fatty acid-induced inhibition of glucose uptake
-
Boden G Chen X Ruiz J et al. Mechanisms of fatty acid-induced inhibition of glucose uptake Journal of Clinical Investigation 93 1994 2438-2446
-
(1994)
Journal of Clinical Investigation
, vol.93
, pp. 2438-2446
-
-
Boden, G.1
Chen, X.2
Ruiz, J.3
-
63
-
-
50549202600
-
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
Randle P J Garland P B Hales C N Newholme C A The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet i 1963 785-789
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
Garland, P.B.2
Hales, C.N.3
Newholme, C.A.4
-
65
-
-
0028233560
-
Importance of the modulation of glycolysis in the control of lactate metabolism by fatty acids in isolated hepatocytes from fed rats
-
Morand C Besson C Demigne C Remesy C Importance of the modulation of glycolysis in the control of lactate metabolism by fatty acids in isolated hepatocytes from fed rats Archives of Biochemistry and Biophysics 309 1994 254-260
-
(1994)
Archives of Biochemistry and Biophysics
, vol.309
, pp. 254-260
-
-
Morand, C.1
Besson, C.2
Demigne, C.3
Remesy, C.4
-
66
-
-
0016292966
-
The role of acetyl-CoA in the reaction pathway of pig-liver pyruvate carboxylase
-
Warren G B Tipton K F The role of acetyl-CoA in the reaction pathway of pig-liver pyruvate carboxylase European Journal of Biochemistry 47 1974 549-554
-
(1974)
European Journal of Biochemistry
, vol.47
, pp. 549-554
-
-
Warren, G.B.1
Tipton, K.F.2
-
67
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki H Paterson J Shinyama H et al. A transgenic model of visceral obesity and the metabolic syndrome Science 294 2001 2166-2170
-
(2001)
Science
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
Paterson, J.2
Shinyama, H.3
-
69
-
-
0034522646
-
The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis
-
Tomlinson J W Bujalska I Stewart P M Cooper M S The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis Endocrine Research 26 2000 711-722
-
(2000)
Endocrine Research
, vol.26
, pp. 711-722
-
-
Tomlinson, J.W.1
Bujalska, I.2
Stewart, P.M.3
Cooper, M.S.4
-
70
-
-
0030630131
-
New concepts in extracellular signaling for insulin action: The single gateway hypothesis
-
Bergman R N New concepts in extracellular signaling for insulin action: the single gateway hypothesis Recent Progress in Hormone Research 52 1997 359-385
-
(1997)
Recent Progress in Hormone Research
, vol.52
, pp. 359-385
-
-
Bergman, R.N.1
-
71
-
-
0028033268
-
The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression
-
Gulick T Cresci S Caira T et al. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression Proceedings of the National Academy of Sciences of the USA 91 1994 11012-11016
-
(1994)
Proceedings of the National Academy of Sciences of the USA
, vol.91
, pp. 11012-11016
-
-
Gulick, T.1
Cresci, S.2
Caira, T.3
-
72
-
-
0030029605
-
Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
-
Prentki M Corkey B E Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45 1996 273-283
-
(1996)
Diabetes
, vol.45
, pp. 273-283
-
-
Prentki, M.1
Corkey, B.E.2
-
73
-
-
0027982057
-
Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamsters
-
Hardardottir I Kunitake S T Moser A H et al. Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamsters Journal of Clinical Investigation 94 1994 1304-1309
-
(1994)
Journal of Clinical Investigation
, vol.94
, pp. 1304-1309
-
-
Hardardottir, I.1
Kunitake, S.T.2
Moser, A.H.3
-
74
-
-
0032587240
-
The role of TNFalpha and TNF receptors in obesity and insulin resistance
-
Hotamisligil G S The role of TNFalpha and TNF receptors in obesity and insulin resistance Journal of Internal Medicine 245 1999 621-625
-
(1999)
Journal of Internal Medicine
, vol.245
, pp. 621-625
-
-
Hotamisligil, G.S.1
-
75
-
-
1842405349
-
Leptin directly alters lipid partitioning in skeletal muscle
-
Muoio D M Dohm G L Fiedorek F T Jr. et al. Leptin directly alters lipid partitioning in skeletal muscle Diabetes 46 1997 1360-1363
-
(1997)
Diabetes
, vol.46
, pp. 1360-1363
-
-
Muoio, D.M.1
Dohm, G.L.2
Fiedorek Jr., F.T.3
-
76
-
-
0029048408
-
Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
-
Campfield L A Smith F J Guisez Y et al. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546-549
-
(1995)
Science
, vol.269
, pp. 546-549
-
-
Campfield, L.A.1
Smith, F.J.2
Guisez, Y.3
-
77
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
Halaas J L Gajiwala K S Maffei M et al. Weight-reducing effects of the plasma protein encoded by the obese gene Science 269 1995 543-546
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
-
78
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi T Kamon J Waki H et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nature Medicine 7 2001 941-946
-
(2001)
Nature Medicine
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
-
80
-
-
0018520840
-
Glucose clamp technique: A method for quantifying insulin secretion and resistance
-
DeFronzo R A Tobin J D Andres R Glucose clamp technique: a method for quantifying insulin secretion and resistance American Journal of Physiology 237 1979 E214-E223
-
(1979)
American Journal of Physiology
, vol.237
-
-
DeFronzo, R.A.1
Tobin, J.D.2
Andres, R.3
-
81
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews D R Hosker J P Rudenski A S et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412-419
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
-
82
-
-
0034456568
-
Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
-
Katz A Nambi S S Mather K et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans Journal of Clinical Endocrinology and Metabolism 85 2000 2402-2410
-
(2000)
Journal of Clinical Endocrinology and Metabolism
, vol.85
, pp. 2402-2410
-
-
Katz, A.1
Nambi, S.S.2
Mather, K.3
-
83
-
-
0015781421
-
Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects
-
Olefsky J Farquhar J W Reaven G Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects Diabetes 22 1973 507-513
-
(1973)
Diabetes
, vol.22
, pp. 507-513
-
-
Olefsky, J.1
Farquhar, J.W.2
Reaven, G.3
-
84
-
-
0032821965
-
Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
-
Matsuda M DeFronzo R A Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp Diabetes Care 22 1999 1462-1470
-
(1999)
Diabetes Care
, vol.22
, pp. 1462-1470
-
-
Matsuda, M.1
DeFronzo, R.A.2
-
85
-
-
0026474342
-
A simple method for quantitation of insulin sensitivity and insulin release from an intravenous glucose tolerance test
-
Galvin P Ward G Walters J et al. A simple method for quantitation of insulin sensitivity and insulin release from an intravenous glucose tolerance test Diabetic Medicine 9 1992 921-928
-
(1992)
Diabetic Medicine
, vol.9
, pp. 921-928
-
-
Galvin, P.1
Ward, G.2
Walters, J.3
-
87
-
-
0021691098
-
Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
-
Bogardus C Lillioja S Howard B V et al. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects Journal of Clinical Investigation 74 1984 1238-1246
-
(1984)
Journal of Clinical Investigation
, vol.74
, pp. 1238-1246
-
-
Bogardus, C.1
Lillioja, S.2
Howard, B.V.3
-
88
-
-
0023188310
-
Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance
-
Hollenbeck C Reaven G M Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance Journal of Clinical Endocrinology and Metabolism 64 1987 1169-1173
-
(1987)
Journal of Clinical Endocrinology and Metabolism
, vol.64
, pp. 1169-1173
-
-
Hollenbeck, C.1
Reaven, G.M.2
-
90
-
-
0023226232
-
Insulin suppression of plasma-free fatty acid concentration in normal individuals and patients with type 2 (non-insulin-dependent) diabetes
-
Swislocki A L Chen Y D Golay A et al. Insulin suppression of plasma-free fatty acid concentration in normal individuals and patients with type 2 (non-insulin-dependent) diabetes Diabetologia 30 1987 622-626
-
(1987)
Diabetologia
, vol.30
, pp. 622-626
-
-
Swislocki, A.L.1
Chen, Y.D.2
Golay, A.3
-
92
-
-
0014336451
-
Study of the relationship between glucose and insulin responses to an oral glucose load in man
-
Reaven G Miller R Study of the relationship between glucose and insulin responses to an oral glucose load in man Diabetes 17 1968 560-569
-
(1968)
Diabetes
, vol.17
, pp. 560-569
-
-
Reaven, G.1
Miller, R.2
-
93
-
-
0034941121
-
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
-
Magre J Delepine M Khallouf E et al. Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13 Nature Genetics 28 2001 365-370
-
(2001)
Nature Genetics
, vol.28
, pp. 365-370
-
-
Magre, J.1
Delepine, M.2
Khallouf, E.3
-
95
-
-
0033517284
-
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
-
Shimomura I Hammer R E Ikemoto S et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401 1999 73-76
-
(1999)
Nature
, vol.401
, pp. 73-76
-
-
Shimomura, I.1
Hammer, R.E.2
Ikemoto, S.3
-
96
-
-
0036156326
-
Leptin and adipose tissue maldistribution in HIV-infected male patients with predominant fat loss treated with antiretroviral therapy
-
Estrada V Serrano-Rios M Larrad M T et al. Leptin and adipose tissue maldistribution in HIV-infected male patients with predominant fat loss treated with antiretroviral therapy Journal of Acquired Immune Deficiency Syndrome 29 2002 32-40
-
(2002)
Journal of Acquired Immune Deficiency Syndrome
, vol.29
, pp. 32-40
-
-
Estrada, V.1
Serrano-Rios, M.2
Larrad, M.T.3
-
97
-
-
0032551258
-
Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance
-
Carr A Samaras K Chisholm D J Cooper D A Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance Lancet 351 1998 1881-1883
-
(1998)
Lancet
, vol.351
, pp. 1881-1883
-
-
Carr, A.1
Samaras, K.2
Chisholm, D.J.3
Cooper, D.A.4
-
98
-
-
0034051079
-
Effects of troglitazone on insulin sensitivity in HIV-infected patients with protease inhibitor-associated diabetes mellitus
-
Walli R Michl G M Muhlbayer D et al. Effects of troglitazone on insulin sensitivity in HIV-infected patients with protease inhibitor-associated diabetes mellitus Research in Experimental Medicine 199 2000 253-262
-
(2000)
Research in Experimental Medicine
, vol.199
, pp. 253-262
-
-
Walli, R.1
Michl, G.M.2
Muhlbayer, D.3
-
100
-
-
0035204779
-
Mitochondria in the pathogenesis of lipodystrophy induced by anti-HIV antiretroviral drugs: Actors or bystanders?
-
Cossarizza A Mussini C Vigano A Mitochondria in the pathogenesis of lipodystrophy induced by anti-HIV antiretroviral drugs: actors or bystanders? Bioessays 23 2001 1070-1080
-
(2001)
Bioessays
, vol.23
, pp. 1070-1080
-
-
Cossarizza, A.1
Mussini, C.2
Vigano, A.3
-
101
-
-
0024542475
-
Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor
-
Lancaster J R Jr. Laster S M Gooding L R Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor FEBS Letters 248 1989 169-174
-
(1989)
FEBS Letters
, vol.248
, pp. 169-174
-
-
Lancaster jR., J.R.1
Laster, S.M.2
Gooding, L.R.3
-
103
-
-
0033872036
-
Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line
-
Pierce R H Campbell J S Stephenson A B et al. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line American Journal of Pathology 157 2000 221-236
-
(2000)
American Journal of Pathology
, vol.157
, pp. 221-236
-
-
Pierce, R.H.1
Campbell, J.S.2
Stephenson, A.B.3
-
105
-
-
0032496339
-
Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE). Role of HNE adduct formation with the enzyme subunits
-
1380
-
Chen J Schenker S Frosto T A Henderson G I Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE). Role of HNE adduct formation with the enzyme subunits Biochimica Biophysica Acta 1380 1998 336-344
-
(1998)
Biochimica Biophysica Acta
, pp. 336-344
-
-
Chen, J.1
Schenker, S.2
Frosto, T.A.3
Henderson, G.I.4
-
106
-
-
0033793133
-
Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
-
Chinetti G Fruchart J C Staels B Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation Inflammation Research 49 2000 497-505
-
(2000)
Inflammation Research
, vol.49
, pp. 497-505
-
-
Chinetti, G.1
Fruchart, J.C.2
Staels, B.3
-
107
-
-
0029128915
-
Alterations of peroxisomes in steatosis of the human liver: A quantitative study
-
De Craemer D Pauwels M Van den B C Alterations of peroxisomes in steatosis of the human liver: a quantitative study Hepatology 22 1995 744-752
-
(1995)
Hepatology
, vol.22
, pp. 744-752
-
-
De Craemer, D.1
Pauwels, M.2
Van den, B.C.3
-
108
-
-
18244364864
-
NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
-
Chitturi S Abeygunasekera S Farrell G C et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome Hepatology 35 2002 373-379
-
(2002)
Hepatology
, vol.35
, pp. 373-379
-
-
Chitturi, S.1
Abeygunasekera, S.2
Farrell, G.C.3
-
110
-
-
0022388940
-
Ambient plasma free fatty acid concentrations in noninsulin-dependent diabetes mellitus: Evidence for insulin resistance
-
Fraze E Donner C C Swislocki A L et al. Ambient plasma free fatty acid concentrations in noninsulin-dependent diabetes mellitus: evidence for insulin resistance Journal of Clinical Endocrinology and Metabolism 61 1985 807-811
-
(1985)
Journal of Clinical Endocrinology and Metabolism
, vol.61
, pp. 807-811
-
-
Fraze, E.1
Donner, C.C.2
Swislocki, A.L.3
-
111
-
-
0035804251
-
The lipid phosphatase SHIP2 controls insulin sensitivity
-
Clement S Krause U Desmedt F et al. The lipid phosphatase SHIP2 controls insulin sensitivity Nature 409 2001 92-97
-
(2001)
Nature
, vol.409
, pp. 92-97
-
-
Clement, S.1
Krause, U.2
Desmedt, F.3
-
112
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
Cho H Mu J Kim J K et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) Science 292 2001 1728-1731
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
-
113
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
Elchebly M Payette P Michaliszyn E et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene Science 283 1999 1544-1548
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
-
114
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers D J Gutierrez J S Towery H et al. Disruption of IRS-2 causes type 2 diabetes in mice Nature 391 1998 900-904
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
-
115
-
-
10144229102
-
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 and identification of insulin receptor substrate-2
-
Kadowaki T Tamemoto H Tobe K et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 and identification of insulin receptor substrate-2 Diabetic Medicine 13 1996 S103-S108
-
(1996)
Diabetic Medicine
, vol.13
-
-
Kadowaki, T.1
Tamemoto, H.2
Tobe, K.3
-
116
-
-
0029148426
-
Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
-
Katz E B Stenbit A E Hatton K et al. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4 Nature 377 1995 151-155
-
(1995)
Nature
, vol.377
, pp. 151-155
-
-
Katz, E.B.1
Stenbit, A.E.2
Hatton, K.3
-
117
-
-
0033757592
-
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha
-
Fruman D A Mauvais-Jarvis F Pollard D A et al. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha Nature Genetics 26 2000 379-382
-
(2000)
Nature Genetics
, vol.26
, pp. 379-382
-
-
Fruman, D.A.1
Mauvais-Jarvis, F.2
Pollard, D.A.3
-
118
-
-
0030024814
-
Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites
-
Pillay T S Xiao S Olefsky J Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites Journal of Clinical Investigation 97 1996 613-620
-
(1996)
Journal of Clinical Investigation
, vol.97
, pp. 613-620
-
-
Pillay, T.S.1
Xiao, S.2
Olefsky, J.3
|