메뉴 건너뛰기




Volumn 31, Issue 12, 1999, Pages 626-631

The role of TNF-α in human adipose tissue: Prevention of weight gain at the expense of insulin resistance?

Author keywords

Adipose Differentiation; Human Adipose Tissue; Insulin Resistance; Obesity; Tumor Necrosis Factor

Indexed keywords

GLYCEROL 3 PHOSPHATE DEHYDROGENASE; PEROXISOME PROLIFERATOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033393956     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978810     Document Type: Review
Times cited : (136)

References (67)
  • 2
    • 0000072070 scopus 로고
    • Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells
    • 2 Kawakami M, Pekala PH, Lane DM, Cerami A. Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells. Proc Natl Acad Sci USA 1982; 79: 912-916
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 912-916
    • Kawakami, M.1    Pekala, P.H.2    Lane, D.M.3    Cerami, A.4
  • 4
    • 0029928366 scopus 로고    scopus 로고
    • Tumor necrosis factors: Developments in the last decade
    • 4 Aggarwal BB, Natarajan K. Tumor necrosis factors: developments in the last decade. Eur Cytokine Netw 1996; 7: 93-124
    • (1996) Eur Cytokine Netw , vol.7 , pp. 93-124
    • Aggarwal, B.B.1    Natarajan, K.2
  • 5
    • 0026461349 scopus 로고
    • Genomic structure, induction, and production of TNF-alpha
    • 5 Spriggs DR, Deutsch S, Kufe DW. Genomic structure, induction, and production of TNF-alpha. Immunol Ser 1992; 56: 3-34
    • (1992) Immunol Ser , vol.56 , pp. 3-34
    • Spriggs, D.R.1    Deutsch, S.2    Kufe, D.W.3
  • 6
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    • 6 Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 1998; 391: 82-86
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 7
    • 0024281428 scopus 로고
    • A novel form of TNF/ cachectin is a cell surface cytotoxic transmembrane protein; ramifications for the complex physiology of TNF
    • 7 Kriegler M, Perez C, DeFay K, Albert I, Lu SD. A novel form of TNF/ cachectin is a cell surface cytotoxic transmembrane protein; ramifications for the complex physiology of TNF. Cell 1988; 53: 45-53
    • (1988) Cell , vol.53 , pp. 45-53
    • Kriegler, M.1    Perez, C.2    DeFay, K.3    Albert, I.4    Lu, S.D.5
  • 9
    • 0028353492 scopus 로고
    • The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation and death
    • 9 Smith CA, Farrah T, Goodwin RG. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation and death. Cell 1994; 76: 959-962
    • (1994) Cell , vol.76 , pp. 959-962
    • Smith, C.A.1    Farrah, T.2    Goodwin, R.G.3
  • 14
    • 0027934198 scopus 로고
    • Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils
    • 14 Porteau F, Hieblot C. Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils. J Biol Chem 1994; 269: 2834-2840
    • (1994) J Biol Chem , vol.269 , pp. 2834-2840
    • Porteau, F.1    Hieblot, C.2
  • 15
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • 15 Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 16
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue, regulation by obesity, weight loss and relationship to lipoprotein lipase
    • 16 Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue, regulation by obesity, weight loss and relationship to lipoprotein lipase. J Clin Invest 1995; 95: 2111-2119
    • (1995) J Clin Invest , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 17
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • 17 Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409-2415
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 18
    • 0032811118 scopus 로고    scopus 로고
    • Expression pattern of tumour necrosis factor receptors in subcutaneous and omental human adipose tissue: Role of obesity and non-insulin-dependent diabetes mellitus
    • 18 Hube F. Birgel M, Lee Y-M, Hauner H. Expression pattern of tumour necrosis factor receptors in subcutaneous and omental human adipose tissue: role of obesity and non-insulin-dependent diabetes mellitus. Eur J Clin Invest 1999; 29: 672-678
    • (1999) Eur J Clin Invest , vol.29 , pp. 672-678
    • Hube, F.1    Birgel, M.2    Lee, Y.-M.3    Hauner, H.4
  • 19
    • 0033024041 scopus 로고    scopus 로고
    • The phosphodiesterase inhibitor IBMX suppresses TNF-α expression in human adipocyte precursor cells: A possible explanation for its adipogenic effect
    • 19 Hube F, Lee Y-M, Röhrig K, Hauner H. The phosphodiesterase inhibitor IBMX suppresses TNF-α expression in human adipocyte precursor cells: a possible explanation for its adipogenic effect. Horm Metab Res 1999; 31: 359-362
    • (1999) Horm Metab Res , vol.31 , pp. 359-362
    • Hube, F.1    Lee, Y.-M.2    Röhrig, K.3    Hauner, H.4
  • 20
    • 0030862338 scopus 로고    scopus 로고
    • High fat diets elevate tissue-derived tumor necrosis factor-α activity
    • 20 Morin CL, Eckel RH, Marcel T, Pagliassotti MJ. High fat diets elevate tissue-derived tumor necrosis factor-α activity. Endocrinology 1997; 138: 4665-4671
    • (1997) Endocrinology , vol.138 , pp. 4665-4671
    • Morin, C.L.1    Eckel, R.H.2    Marcel, T.3    Pagliassotti, M.J.4
  • 21
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • 21 Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 1996; 274: 1377-1379
    • (1996) Science , vol.274 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, R.S.2    Distel, R.J.3    Ellis, R.4    Papaioannou, V.E.5    Spiegelman, B.M.6
  • 22
    • 0031053823 scopus 로고    scopus 로고
    • Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
    • 22 Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 1997; 46: 451-455
    • (1997) Diabetes , vol.46 , pp. 451-455
    • Hotamisligil, G.S.1    Arner, P.2    Atkinson, R.L.3    Spiegelman, B.M.4
  • 23
    • 0030481074 scopus 로고    scopus 로고
    • Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity
    • 23 Kellerer M, Rett K, Groop L, Häring HU. Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity. Horm Metab Res 1996; 28: 737-743
    • (1996) Horm Metab Res , vol.28 , pp. 737-743
    • Kellerer, M.1    Rett, K.2    Groop, L.3    Häring, H.U.4
  • 24
    • 0031793066 scopus 로고    scopus 로고
    • Plasma concentrations of TNF-α and its soluble receptors in obese subjects
    • 24 Hauner H, Bender M, Haastert B, Hube F. Plasma concentrations of TNF-α and its soluble receptors in obese subjects. Int J Obesity 1998; 22: 1239-1243
    • (1998) Int J Obesity , vol.22 , pp. 1239-1243
    • Hauner, H.1    Bender, M.2    Haastert, B.3    Hube, F.4
  • 27
    • 0023202754 scopus 로고
    • Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo
    • 27 Semb H, Peterson J, Tavernier J, Olivecrona T. Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo. J Biol Chem 1987; 262: 8390-8394
    • (1987) J Biol Chem , vol.262 , pp. 8390-8394
    • Semb, H.1    Peterson, J.2    Tavernier, J.3    Olivecrona, T.4
  • 28
    • 0023871823 scopus 로고
    • Regulation of lipoprotein lipase mRNA content in 3T3-L1 cells by tumor necrosis factor
    • 28 Cornelius P, Enerback S, Bjursell G, Olivecrona T, Pekala PH. Regulation of lipoprotein lipase mRNA content in 3T3-L1 cells by tumor necrosis factor. Biochem J 1988; 249: 765-769
    • (1988) Biochem J , vol.249 , pp. 765-769
    • Cornelius, P.1    Enerback, S.2    Bjursell, G.3    Olivecrona, T.4    Pekala, P.H.5
  • 29
    • 0024836241 scopus 로고
    • Cachectin/tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis, and activity
    • 29 Fried SK, Zechner R. Cachectin/tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis, and activity. J Lipid Res 1989; 30: 1917-1923
    • (1989) J Lipid Res , vol.30 , pp. 1917-1923
    • Fried, S.K.1    Zechner, R.2
  • 30
    • 0024566348 scopus 로고
    • Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor β
    • 30 Torti FM, Torti SV, Larrick JW, Ringold GM. Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor β. J Cell Biol 1989; 108: 1105-1113
    • (1989) J Cell Biol , vol.108 , pp. 1105-1113
    • Torti, F.M.1    Torti, S.V.2    Larrick, J.W.3    Ringold, G.M.4
  • 31
    • 0025837140 scopus 로고
    • Transcriptional repression of Glut-4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor alpha
    • 31 Stephens JM, Pekala PH. Transcriptional repression of Glut-4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor alpha. J Biol Chem 1992; 266: 21839-21845
    • (1992) J Biol Chem , vol.266 , pp. 21839-21845
    • Stephens, J.M.1    Pekala, P.H.2
  • 32
    • 0030972203 scopus 로고    scopus 로고
    • TNF-alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression
    • 32 Xing H, Northrop JP, Grove JR, Kilpatrick KE, Su JL, Ringold GM. TNF-alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression. Endocrinology 1997; 138: 2776-2783
    • (1997) Endocrinology , vol.138 , pp. 2776-2783
    • Xing, H.1    Northrop, J.P.2    Grove, J.R.3    Kilpatrick, K.E.4    Su, J.L.5    Ringold, G.M.6
  • 33
    • 0029062839 scopus 로고
    • Transcriptional regulation of gene expression during adipocyte differentiation
    • 33 MacDougald OA, Lane D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 1995; 64: 345-373
    • (1995) Annu Rev Biochem , vol.64 , pp. 345-373
    • MacDougald, O.A.1    Lane, D.2
  • 34
    • 0024405231 scopus 로고
    • Cachectin/tumor necrosis factor and interleukin-1 show different modes of combined effect on lipoprotein lipase and intracellular lipolysis in 3T3-L1 cells
    • 34 Ogawa H, Nielsen S, Kawakami M. Cachectin/tumor necrosis factor and interleukin-1 show different modes of combined effect on lipoprotein lipase and intracellular lipolysis in 3T3-L1 cells. Biochim Biophys Acta 1989; 1003: 131-135
    • (1989) Biochim Biophys Acta , vol.1003 , pp. 131-135
    • Ogawa, H.1    Nielsen, S.2    Kawakami, M.3
  • 35
    • 0029041905 scopus 로고
    • Effects of tumour necrosis factor alpha (TNF) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture
    • 35 Hauner H, Petruschke T, Russ M, Röhrig K, Eckel J. Effects of tumour necrosis factor alpha (TNF) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture. Diabetologia 1995; 38: 764-771
    • (1995) Diabetologia , vol.38 , pp. 764-771
    • Hauner, H.1    Petruschke, T.2    Russ, M.3    Röhrig, K.4    Eckel, J.5
  • 36
    • 0033304608 scopus 로고    scopus 로고
    • The differential effect of food intake and β-adrenergic stimulation on adipose-derived hormones and cytokines in man
    • 36 Orban Z, Remaley AT, Sampson M, Trajanoski Z, Chrousos GP. The differential effect of food intake and β-adrenergic stimulation on adipose-derived hormones and cytokines in man. J Clin Endocrinol Metab 1999; 84: 2126-2133
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2126-2133
    • Orban, Z.1    Remaley, A.T.2    Sampson, M.3    Trajanoski, Z.4    Chrousos, G.P.5
  • 37
    • 1842360052 scopus 로고
    • Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells
    • 37 Pekala PH, Kawakami M, Angus CW, Lane MD, Cerami A. Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells. Proc Natl Acad Sci 1983; 80: 2743-2747
    • (1983) Proc Natl Acad Sci , vol.80 , pp. 2743-2747
    • Pekala, P.H.1    Kawakami, M.2    Angus, C.W.3    Lane, M.D.4    Cerami, A.5
  • 38
    • 0027405166 scopus 로고
    • Tumor necrosis factor-alpha prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells
    • 38 Petruschke T, Hauner H. Tumor necrosis factor-alpha prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells. J Clin Endocrinol Metab 1993; 76: 742-747
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 742-747
    • Petruschke, T.1    Hauner, H.2
  • 39
    • 0027332738 scopus 로고
    • Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
    • 39 Feinstein R, Kanety H, Papa MZ, Lunenfeld B, Karasik A. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem 1993; 268: 26055-26058
    • (1993) J Biol Chem , vol.268 , pp. 26055-26058
    • Feinstein, R.1    Kanety, H.2    Papa, M.Z.3    Lunenfeld, B.4    Karasik, A.5
  • 41
    • 0028825748 scopus 로고
    • Tumor necrosis factor α-induced phosphorylation of insulin receptor substrate-1 (IRS1)
    • 41 Kanety H, Feinstein R, Papa MZ, Hemi R, Karasik A. Tumor necrosis factor α-induced phosphorylation of insulin receptor substrate-1 (IRS1). J Biol Chem 1995; 270: 23780-23784
    • (1995) J Biol Chem , vol.270 , pp. 23780-23784
    • Kanety, H.1    Feinstein, R.2    Papa, M.Z.3    Hemi, R.4    Karasik, A.5
  • 42
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance
    • 42 Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 1996; 271: 665-668
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 44
    • 0031022434 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
    • 44 Stephens JM, Lee J, Pilch PF. Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem 1997; 272: 971-976
    • (1997) J Biol Chem , vol.272 , pp. 971-976
    • Stephens, J.M.1    Lee, J.2    Pilch, P.F.3
  • 45
    • 0029933665 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase
    • 45 Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem 1996; 271: 13018-13022
    • (1996) J Biol Chem , vol.271 , pp. 13018-13022
    • Peraldi, P.1    Hotamisligil, G.S.2    Buurman, W.A.3    White, M.F.4    Spiegelman, B.M.5
  • 46
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced thyrosine phosphorylation
    • 46 Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced thyrosine phosphorylation. J Biol Chem 1997; 272: 29911-29918
    • (1997) J Biol Chem , vol.272 , pp. 29911-29918
    • Paz, K.1    Hemi, R.2    LeRoith, D.3    Karasik, A.4    Elhanany, E.5    Kanety, H.6
  • 47
    • 0031793622 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes
    • 47 Valverde AM, Teruel T, Navarro P, Benito M, Lorenzo M. Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes. Endocrinology 1998; 139: 1229-1238
    • (1998) Endocrinology , vol.139 , pp. 1229-1238
    • Valverde, A.M.1    Teruel, T.2    Navarro, P.3    Benito, M.4    Lorenzo, M.5
  • 48
    • 0041009626 scopus 로고    scopus 로고
    • Tumor necrosis factor-α acutely inhibits insulin signaling in human adipocytes. Implication of the p80 tumor necrosis factor receptor
    • 48 Liu LS, Spelleken M, Röhrig K, Hauner H, Eckel J. Tumor necrosis factor-α acutely inhibits insulin signaling in human adipocytes. Implication of the p80 tumor necrosis factor receptor. Diabetes 1998; 47: 515-522
    • (1998) Diabetes , vol.47 , pp. 515-522
    • Liu, L.S.1    Spelleken, M.2    Röhrig, K.3    Hauner, H.4    Eckel, J.5
  • 49
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF-α antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
    • 49 Ofei F, Hurel S, Newkirk J, Sopwith M, Taylor R. Effects of an engineered human anti-TNF-α antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 1996; 45: 881-885
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 50
    • 0029874429 scopus 로고    scopus 로고
    • Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1
    • 50 Kanety H, Hemi R, Papa MZ, Karasik A. Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1. J Biol Chem 1996; 271: 9895-9897
    • (1996) J Biol Chem , vol.271 , pp. 9895-9897
    • Kanety, H.1    Hemi, R.2    Papa, M.Z.3    Karasik, A.4
  • 51
    • 0031964986 scopus 로고    scopus 로고
    • Effects of cell-permeable ceramides and tumor necrosis factor-α on insulin signaling and glucose uptake in 3T3-L1 adipocytes
    • 51 Wang C-N, O'Brien L, Brindley DN. Effects of cell-permeable ceramides and tumor necrosis factor-α on insulin signaling and glucose uptake in 3T3-L1 adipocytes. Diabetes 1998; 47: 24-31
    • (1998) Diabetes , vol.47 , pp. 24-31
    • Wang, C.-N.1    O'Brien, L.2    Brindley, D.N.3
  • 52
    • 0032528177 scopus 로고    scopus 로고
    • Obesity and diabetes in TNF-α receptor-deficient mice
    • 52 Schreyer SA, Streamson CC, LeBoeuf RC. Obesity and diabetes in TNF-α receptor-deficient mice. J Clin Invest 1998; 102: 402-441
    • (1998) J Clin Invest , vol.102 , pp. 402-441
    • Schreyer, S.A.1    Streamson, C.C.2    LeBoeuf, R.C.3
  • 53
    • 0031757099 scopus 로고    scopus 로고
    • Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α-mediated insulin resistance in genetic obesity
    • 53 Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α-mediated insulin resistance in genetic obesity. Endocrinology 1998; 139: 4832-4838
    • (1998) Endocrinology , vol.139 , pp. 4832-4838
    • Uysal, K.T.1    Wiesbrock, S.M.2    Hotamisligil, G.S.3
  • 55
    • 85038052867 scopus 로고    scopus 로고
    • Do the TNF receptors mediate different effects in human adipose tissue?
    • 55 Hauner H, Lee Y-M, Röhrig K, Hube F. Do the TNF receptors mediate different effects in human adipose tissue? Obes Res 1997; 5 Suppl 1:17S
    • (1997) Obes Res , vol.5 , Issue.SUPPL. 1
    • Hauner, H.1    Lee, Y.-M.2    Röhrig, K.3    Hube, F.4
  • 56
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistence in mice lacking TNF-alpha function
    • 56 Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistence in mice lacking TNF-alpha function. Nature 1997; 389: 610-614
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 58
    • 0028916523 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-α on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3 L1 cells
    • 58 Szalkowski D, White-Carrington S, Berger J, Zhang B. Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-α on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3 L1 cells. Endocrinology 1996; 136: 1474-1481
    • (1996) Endocrinology , vol.136 , pp. 1474-1481
    • Szalkowski, D.1    White-Carrington, S.2    Berger, J.3    Zhang, B.4
  • 59
    • 0030885575 scopus 로고    scopus 로고
    • Thiazolidindiones block tumor necrosis factor-α-induced inhibition of insulin signaling
    • 59 Peraldi P, Xu M, Spiegelman BM. Thiazolidindiones block tumor necrosis factor-α-induced inhibition of insulin signaling. J Clin Invest 1997; 100: 1863-1869
    • (1997) J Clin Invest , vol.100 , pp. 1863-1869
    • Peraldi, P.1    Xu, M.2    Spiegelman, B.M.3
  • 60
    • 0030661983 scopus 로고    scopus 로고
    • TNF-α-induced insulin resistance in vivo and its prevention by troglitazone
    • 60 Miles DC, Romeo OM, Higo K, Cohen A, Rafaat K, Olefsky JM. TNF-α-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 1997; 46; 1678-1683
    • (1997) Diabetes , vol.46 , pp. 1678-1683
    • Miles, D.C.1    Romeo, O.M.2    Higo, K.3    Cohen, A.4    Rafaat, K.5    Olefsky, J.M.6
  • 61
    • 0030882762 scopus 로고    scopus 로고
    • Taming TNF: Strategies to restrain this proinflammatory cytokine
    • 61 Eigler A, Sinha B, Hartmann G, Endres S. Taming TNF: Strategies to restrain this proinflammatory cytokine. Immunol Today 1997; 18: 487-492
    • (1997) Immunol Today , vol.18 , pp. 487-492
    • Eigler, A.1    Sinha, B.2    Hartmann, G.3    Endres, S.4
  • 63
    • 0031454125 scopus 로고    scopus 로고
    • Tumor necrosis factor-α contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes
    • 63 Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Tumor necrosis factor-α contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest 1997; 100: 2777-2782
    • (1997) J Clin Invest , vol.100 , pp. 2777-2782
    • Kirchgessner, T.G.1    Uysal, K.T.2    Wiesbrock, S.M.3    Marino, M.W.4    Hotamisligil, G.S.5
  • 64
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • 64 Friedman JM, Haiaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-770
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Haiaas, J.L.2
  • 66
    • 0032706353 scopus 로고    scopus 로고
    • Depot-specific release of leptin from subcutaneous and omental adiocytes in suspension culture: Effect of tumor necrosis factor-α and transforming growth factor-β1
    • 66 Gottschling-Zeller H, Birgel M, Scriba D, Blum WF, Hauner H. Depot-specific release of leptin from subcutaneous and omental adiocytes in suspension culture: effect of tumor necrosis factor-α and transforming growth factor-β1. Eur J Endocrinol 1999; 141: 436-442
    • (1999) Eur J Endocrinol , vol.141 , pp. 436-442
    • Gottschling-Zeller, H.1    Birgel, M.2    Scriba, D.3    Blum, W.F.4    Hauner, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.