Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes

Gastroenterology

Volumn 114, Issue 4 I, 1998, Pages 764-774

  Berson, A ^a   De Beco, V ^a   Letteron, P ^a   Robin, M A ^a   Moreau, C ^a   El Kahwaji, J ^a   Verthier, N ^a   Feldmann, G ^a   Fromenty, B ^a   Pessayre, D ^a  

^a BEAUJON HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; HEXESTROL BIS(2 DIETHYLAMINOETHYL) ETHER; PERHEXILINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; HEPATITIS; LIPID PEROXIDATION; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STEATOSIS;

EID: 0031921972     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70590-6     Document Type: Article

References (38)

1. HJ. Zimmerman The adverse effects of drugs and other chemicals on the liver 1978 Appleton-Century-Crofts New York
2. F De La Iglesia G Feuer A Takada Y. Matsuda Morphologic studies on secondary phospholipidosis in human liver Lab Invest 30 1974 539 549
3. D Pessayre M Bichara G Feldmann C Degott F Potet J-P. Benhamou Perhexiline-maleate induced cirrhosis Gastroenterology 76 1979 170 177
4. JB Simon PN Manley JF Brien PW. Armstrong Amiodarone hepatotoxicity simulating alcoholic liver disease N Engl J Med 311 1984 167 172
5. S Poucell J Ireton P Valencia-Mayoral E Downar L Larratt J Patterson L Blendis MJ. Phillips Amiodarone-associated phospholipidosis and fibrosis of the liver. Light, immunohistochemical, and electron microscopic studies Gastroenterology 86 1984 926 936
6. G. Farrell Drug-induced liver disease 1994 Churchill-Livingstone London
7. UP Kodavanti HM. Mehendale Cationic amphiphilic drugs and phospholipidosis storage disorder Pharmacol Rev 42 1990 327 354
8. 1: role of drug binding to substrate J Pharmacol Exp Ther 240 1987 88 92
9. A Yamamoto S Adachi K Ishikawa T Yokomura T Kitani T Nasu T Imoto M. Nishikawa Studies on drug-induced lipidosis. III. Lipid composition of the liver and some other tissues in clinical cases of “Niemann-Pick–like syndrome” induced by 4,4'-diethylaminoethoxyhexestrol J Biochem 70 1971 775 784
10. B Guigui S Perrot JP Berry J Fleury-Feith N Martin JM Métreau D Dhumeaux ES. Zafrani Amiodarone-induced hepatic phospholipidosis: a morphological alteration independent of pseudoalcoholic liver disease Hepatology 8 1988 1063 1068
11. B Fromenty C Fisch G Labbe C Degott D Deschamps A Berson P Lettéron D. Pessayre Amiodarone inhibits the mitochondrial β-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice J Pharmacol Exp Ther 255 1990 1371 1376
12. B Fromenty C Fisch A Berson P Lettéron D Larrey D. Pessayre Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II J Pharmacol Exp Ther 255 1990 1377 1384
13. B Fromenty P Lettéron C Fisch A Berson D Deschamps D. Pessayre Evaluation of human lymphocytes as a model to study the effects of drugs on human mitochondria. Effects of low concentrations of amiodarone on fatty acid oxidation, ATP levels and cell survival Biochem Pharmacol 46 1993 421 432
14. D Deschamps V De Beco C Fisch B Fromenty A Guillouzo D. Pessayre Inhibition by perhexiline of oxidative phosphorylation and the β-oxidation of fatty acids: possible role in pseudoalcoholic lesions Hepatology 19 1994 948 961
15. P Lettéron B Fromenty B Terris C Degott D. Pessayre Acute and chronic hepatic steatosis leads to in vivo lipid peroxidation in mice J Hepatol 23 1995 16 24
16. S Grimbert C Fisch D Deschamps A Berson B Fromenty G Feldmann D. Pessayre Effects of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancy Am J Physiol 268 1995 G107 G115
17. C Garcia-Ruiz A Collel A Morales N Kaplowitz JC. Fernandez-Checa Role of oxidative stress generated from mitochondrial electron transport chain and mitochondrial electron status in loss of mitochondrial function and activation of transcription factor nuclear factor-κB: studies with isolated mitochondria and rat hepatocytes Mol Pharmacol 48 1995 825 834
18. B Fromenty E Fréneaux G Labbe D Deschamps D Larrey P Lettéron D. Pessayre Tianeptine, a new tricyclic antidepressant metabolized by β-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice Biochem Pharmacol 38 1989 3743 3751
19. J Bremer G Woldegiorgis K Schalinske E. Shrago Carnitine palmitoyltransferase. Activation by palmitoyl-CoA and inactivation by malonyl-CoA Biochim Biophys Acta 833 1985 9 16
20. P Lettéron N Brahimi-Bourouina MA Robin A Moreau G Feldmann D. Pessayre Glucocorticoids inhibit mitochondrial matrix acylcoenzyme A dehydrogenases and fatty acid β-oxidation Am J Physiol 272 1997 G1140 G1150
21. C Fisch MA Robin P Lettéron B Fromenty A Berson S Renault C Chachaty D. Pessayre Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo Gastroenterology 110 1996 210 220
22. A Berson S Renault P Lettéron MA Robin B Fromenty D Fau MA Le Bot C Riché AM Durand-Schneider G Feldmann D. Pessayre Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction Gastroenterology 110 1996 1878 1890
23. D Fau A Berson D Eugène B Fromenty C Fisch D. Pessayre Mechanism for the hepatotoxicity of the anti-androgen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes J Pharmacol Exp Ther 263 1992 69 77
24. M Tinel MA Robin J Doostzadeh M Maratrat F Ballet N Fardel J El Kahhwaji P Beaune M Daujat G Labbe D. Pessayre The interleukin-2 receptor down-regulates the expression of cytochrome P450 in cultured rat hepatocytes Gastroenterology 109 1995 1589 1599
25. KD Garlid RA. Nakashima Studies on the mechanism of uncoupling by amine local anesthetics: evidence for mitochondrial proton transport mediated by lipophilic ion pairs J Biol Chem 258 1983 7974 7980
26. B Fromenty D. Pessayre Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity Pharmacol Ther 67 1995 101 154
27. MD Weltman GC Farrell C. Liddle Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation Gastroenterology 111 1996 1645 1653
28. MK Shigenaga TM Hagen BN. Ames Oxidative damage and mitochondrial decay in aging Proc Natl Acad Sci USA 91 1994 10771 10778
29. W Levin AYH Lu M Jacobson R. Kuntzman Lipid peroxidation and the degradation of cytochrome P-450 heme Arch Biochem Biophys 158 1973 842 852
30. RC Zangar RF. Novak Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes Arch Biochem Biophys 337 1997 217 224
31. H Esterbauer RJ Schaur H. Zollner Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes Free Radic Biol Med 1 1991 81 128
32. Y Katsuma SHH Swierenga U Khettry N Marceau SW. French Changes in the cytokeratin intermediate filament cytoskeleton associated with Mallory body formation in mouse and human liver Hepatology 6 1987 1215 1223
33. K Zatloukal G Böck I Rainer H Denk H. Weber High molecular weight components are main constituents of Mallory bodies isolated with a fluorescence activated cell sorter Lab Invest 64 1991 200 206
34. M Curzio H Esterbauer MU. Dianzani Chemotactic activity of hydroxyalkenals on rat neutrophils Int J Tissue React 7 1985 137 142
35. H Tsukamoto CW Kim ZZ Luo W Horn LC Su GM. Brittenham Role of lipid peroxidation in in vivo and in vitro models of liver fibrogenesis (abstr) Gastroenterology 104 1993 A1012
36. P Bedossa K Houglum C Trautwein A Holstege M. Chojkier Stimulation of collagen α1 (I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology 19 1994 1262 1271
37. B Fromenty S Grimbert A Mansouri M Beaugrand S Erlinger A Rötig D. Pessayre Hepatic mitochondrial deletion in alcoholics: association with microvesicular steatosis Gastroenterology 108 1995 193 200
38. P Lettéron V Duchatelle A Berson B Fromenty C Fisch C Degott JP Benhamou D. Pessayre Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol abusers Gut 34 1993 409 414