New connections in the regulation of PEPCK gene expression by insulin

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 351, Issue 1336, 1996, Pages 191-199

  Sutherland, Calum ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

GENE EXPRESSION REGULATION; GENETICS; REVIEW; SIGNAL TRANSDUCTION;

GENE EXPRESSION REGULATION, ENZYMOLOGIC; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SIGNAL TRANSDUCTION;

EID: 0030605384     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1996.0016     Document Type: Article

References (92)

1. Ahn, N. G., Seger, R., Bratlien, R. L., Diltz, C. D., Tonks, N. K. & Krebs, E. G. 1991 Multiple Components in an Epidermal Growth Factor-stimulated Protein Kinase Cascade. J. Biol. Chem. 266, 4220-4227.
2. Angrand, P.-O., Coffinier, C. & Weiss, M. C. 1994 Response of the PEPCK gene to glucocorticoids depends on the integrity of the cAMP pathway. Cell Growth Diff. 5, 957-966.
3. Arcaro, A. & Wymann, M. P. 1993 Wortmannin is a potent PI-3 kinase inhibitor: the role of PI 3,4,5-tris phosphate in neutrophil responses. Biochem. J. 296, 297-301.
4. Auger, K. R., Serunian, L. A., Soltoff, S. P., Libby, P. & Cantley, L. C. 1989 PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57, 167-175.
5. Avruch, J., Zhang, X.-F. & Kyriakis, J. M. 1994 Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19, 279-283.
6. Backer, J. M., Myers, M. G., Shoelson, S. E., Chin, D. J. et al. 1992 PI-3 kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11, 3469-3479.
7. Carpenter, C. L., Auger, K. R., Duckworth, B. C., Hou, W.- M., Schaffhausen, B. & Cantley, L. C. 1993 A tightly associated Ser/Thr protein kinase regulates PI-3 kinase activity. Molec. Cell. Biol. 13, 1657-1665.
8. Chao, T. S., Foster, D. A., Rapp, U. R. & Rosner, M. R. 1994 Differential Raf requirement for activation of MAP kinase by growth factors, phorbol esters, and calcium. J. biol. Chem. 269, 7337-7341.
9. Cheatham, B. & Kahn, C. R. 1995 Insulin Action and the Insulin Signaling Network. Endocr. Rev. 16, 117-147.
10. Cheatham, B., Vlahos, C. J., Cheatham, L., Wang, L., Blenis, J. & Kahn, C. R. 1994 PI-3 kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Molec. Cell. Biol. 14, 4902-1911.
11. Chen, R., Sarnecki, C. & Blenis, J. 1992 Nuclear Localisation and Regulation of erk- and rsk-Encoded Protein Kinases. Molec. Cell. Biol. 12, 915-927.
12. Chu, D. T. W. & Granner, D. K. 1987 The effect of phorbol esters and diacylglycerols on expression of the PEPCK (GTP) gene in rat hepatoma H4IIE cells.J. biol. Chem. 261, 16848-16853.
13. Chu, D. T. W., Stumpo, D. J., Blackshear, P. J. & Granner, D. K. 1987 The inhibition of PEPCK (GTP) gene expression by insulin is not mediated by protein kinase C. Molec. Endocrinol. 1, 53-59.
14. Chung, J., Kuo, C. J., Crabtree, G. R. & Blenis, J. 1992 Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70kDa S6 protein kinases. Cell 69, 1227-1236.
15. rsk activity. Proc. natn Acad. Sci. U.S.A. 88, 4981-4985.
16. Clarke, J. F., Young, P. W., Yonezawa, K., Kasuga, M. & Holman, G. D. 1994 Inhibition of the translocation of GLUT-1 and GLUT-4 in 3T3-L1 cells by wortmannin. Biochem. J. 300, 631-635.
17. Cohen, P., Holmes, C. F. B. & Tsukitana, Y. 1990 Okadaic acid: a new probe for the study of cellular regulation. Treads Biochem. Sci. 15, 98-102.
18. Cross, D. A. E., Alessi, D. R., Vandenheede, J. R., McDowell, H. E., Hundal, H. S. & Cohen, P. 1994 The inhibition of GSK3 by insulin in L6 cells is blocked by wortmannin but not by rapamycin. Biochem. J. 303, 21-26.
19. Davis, R. J. 1994 MAPK's: new JNK expands the group. Trends Biochem. Sci. 19, 470-473.
20. de Vries-Smits, A. M., Burgering, B. M. T., Leevers, S. J., Marshall, C. J. & Bos, J. L. 1992 Involvement of p21 ras in activation of extracellular signal-regulated kinase 2. Nature, Lond. 357, 602-604.
21. Defronzo, R. A. 1988 The Triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37, 667-687.
22. Dent, P., Lavoinne, A., Nakielny, S., Caudwell, F. B., Watt, P. & Cohen, P. 1990 The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature, Lond. 348, 302-308.
23. Denton, R. M. 1986 Early events in insulin actions. Adv. Cyc. Nucl. Prot. Phos. Res. 20, 293-341.
24. Denton, R. M. & Tavare, J. M. 1995 Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against. Eur. J. Biochem. 227, 597-611.
25. Dhand, R., Hiles, I., Panayotou, G., Roche, S. et al. 1994 PI-3 kinase is a duel specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J. 13, 522-533.
26. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J. & Saltiel, A. R. 1995 Identification of a synthetic inhibitor of the MAP kinase cascade. Proc. natn. Acad. Sci. U.S.A. 92, 7686-7689.
27. Errede, B., Gartner, A., Zhou, Z., Nasmyth, K. & Ammerer, G. 1993 MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro. Nature, Lond. 362, 261-264.
28. Errede, B. & Levin, D. 1993 A conserved kinase cascade for MAP kinase activation in yeast. Curr. Opin. Cell Biol. 5, 254-260.
29. Exton, J. H. 1991 Some thoughts on the mechanism of action of insulin. Diabetes 40, 521-526.
30. Ferrari, S. & Thomas, G. 1994 S6 phosphorylation and the P70s6k/p85s6k. Crit. Rev. Biochem. Molec. Biol. 29, 385-413.
31. Filial, C., Valera, A. & Bosch, F. 1993 EGF inhibits PEPCK gene expression in rat hepatocytes in primary culture. FEBS Lett. 318, 287-291.
32. Forest, C. D., O'Brien, R. M., Lucas, P. C., Magnuson, M. A. & Granner, D. K. 1990 Regulation of PEPCK gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Molec. Endocrinol. 4, 1302-1310.
33. Gabbay, R. A., Sutherland, C., Gnudi, L., Khan, B. B., O'Brien, R. M., Granner, D. K. & Flier, J. S. 1995 Insulin regulation of PEPCK gene expression does not require activation of the Ras/MAP linase signaling pathway. J. biol. Chem. (In the press.)
34. Gomez, N. & Cohen, P. 1991 Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinase. Nature, Lond. 353, 170-173.
35. Gonzalez, F. A., Seth, A., Raden, D. L., Bowman, D. S., Fay, F. S. & Davis, R. J. 1993 Serum-Induced Translocation of Mitogen-activated Protein Kinase to the Cell Surface Ruffling Membrane and the Nucleus. J. Cell Biol. 122, 1089-1101.
36. Gould, G. W., Jess, T. J., Andrews, G. C., Herbst, J. J., Plevin, R. J. & Gibbs, E. M. 1994 Evidence for a role of PI-3 kinase in the regulation of glucose transport in Xenopus oocytes. J. biol. Chem. 269, 26622-26625.
37. Granner, D. K. & O'Brien, R. M. 1992 Molecular Physiology and Genetics of NIDDM. Diabet. Care 15, 369-395.
38. Hanson, R. W. & Patel, Y. M. 1994 PEPCK: the gene and the enzyme. Adv. Enzymol. 69, 203-281.
39. Hawkins, P. T., Eguinoa, A., Qui, R.-G., Stokoe, D. et al. 1995 PDGF stimulates an increase in GTP-rac via activation of PI 3-kinase. Curr. Biol. 5, 393-403.
40. Imai, E., Miner, J. N., Mitchell, J. A., Yamamoto, K. R. & Granner, D. K. 1993 Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the PEPCK gene to glucocorticoids. J. biol. Chem. 268, 5353-5356.
41. Imai, E., Stromstedt, P. -E., Quinn, P. G., Carlstedt-Duke, J., Gustafsson, J.-A. & Granner, D. K. 1990 Characterization of a complex glucocorticoid response unit in the PEPCK gene. Molec. Cell Biol. 10, 4712-4719.
42. Kahn, C. R. 1994 Insulin action, Diabetogenes and the cause of Type II Diabetes. Diabetes 43, 1066-1084.
43. Kishi, K., Sosaki, T., Kuroda, S., Itah, T. & Takai, Y. 1993 Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein, rho GDI. J. Cell Biol. 120, 1187-1195.
44. Kotani, K., Yonezawa, K., Hara, K., Ueda, H. et al. 1994 Involvement of PI-3 kinase in insulin- or IGF-1-induced membrane ruffling. EMBO J. 13, 2313-2321.
45. Kuhne, M. R., Pawson, T., Leinhard, G. E. & Feng, G. S. 1993 The insulin receptor substrate-1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J. biol. Chem. 268, 11479-11481.
46. Lazar, D. F., Brady, M. J., Wiese, R. J., Mastick, C. C. et al. 1995 MEK inhibition does not block the stimulation of glucose utilization by insulin. J. biol. Chem. 270, 20801-20807
47. Lee, C. H., Li, W., Nishimura, R., Zhou, M. et al. 1993 Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc. natn Acad. Sci. U.S.A. 90, 11713-11717.
48. Marquardt, B., Frith, D. & Stabel, S. 1994 Signaling from TPA to MAP kinase requires protein kinase C, raf and MEK : reconstitution of the signaling pathway in vitro. Oncogene 9, 3213-3218.
49. Martin, G. A., Bollag, G., McCormick, F. & Abo, A. 1995 A novel serine kinase activated by racl/CDC42Hs-dependent autophosphorylation is related to PAK65. EMBO J. 14, 1970-1978.
50. Messina, J. L., Standaert, M. L., Ishizuka, T., Weinstock, R. S. & Farese, R. V. 1992 . Role of PKC in insulins regulation of c-fos transcription. J. biol. Chem. 267, 9223-9228.
51. Messina, J. L. & Weinstock, R. S. 1994 Evidence for diverse roles of PKC in the inhibition of gene expression by insulin. Endocrinology 135, 2327-2334.
52. Molero, C., Valverde, A. M., Benito, M. & Lorenzo, M. 1992 PEPCK and Glucose 6-Phosphate Dehydrogenase expression in fetal hepatocyte primary cultures under proliferative conditions. Exp. Cell. Res. 200, 295-300.
53. Myers, M. G., Grammer, T. C., Wang, L.-M., Sun, X. J., Pierce, J. H., Blenis, J. & White, M. F. 1994a IRS-1 mediates PI 3-kinase and p70s6k signaling during insulin, IGF1 and IL4 stimulation. J. biol. Chem. 269, 28783-28789.
54. Myers, M. G., Sun, X. J. & White, M. F. 1994b The IRS1 signaling system. Trends Biochem. Sci. 19, 289-293.
55. Nakanishi, H., Brewer, K. A. & Exton, J. H. 1993 Activation of the zeta isozyme of PKC by PI-3,4,5-trisphosphate. J. biol. Chem. 268, 13-16.
56. Northwood, I. C. & Davis, R. J. 1990 Signal transduction by the epidermal growth factor receptor after functional desensitization of the receptor tyrosine protein kinase activity. Proc. natn Acad. Sci. U.S.A. 87, 6107-6111.
57. O'Brien, R. M., Bonovich, M. T., Forest, C. D. & Granner, D. K. 1991 Signal transduction convergence: phorbol esters and insulin inhibit PEPCK gene transcription through the same 10-base-pair sequence. Proc. natn Acad. Sci. U.S.A. 88, 6580-6584.
58. O'Brien, R. M. & Granner, D. K. 1990 PEPCK gene as a model of inhibitory effects of insulin on gene transcription. Diabet. Care 13, 327-339.
59. O'Brien, R. M. & Granner, D. K. 1991 Regulation of gene expression by insulin. Biochem. J. 278, 609-619.
60. O'Brien, R. M. & Granner, D. K. 1995 Regulation of PEPCK gene expression by insulin. Physiol. Rev. (Submitted.)
61. O'Brien, R. M., Lucas, P. C., Forest, C. D., Magnuson, M. A. & Granner, D. K. 1990 Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science, Wash. 249, 533-537.
62. O'Brien, R. M., Lucas, P. L., Yamasaki, T., Noisin, E. L. & Granner, D. K. 1994a Potential convergence of insulin and cAMP signal transduction systems at the PEPCK gene promoter through C/EBP. J. biol. Chem. 269, 30419-30428.
63. O'Brien, R. M., Noisin, E. L. & Granner, D. K. 1994b Comparison of the effects of insulin and okadaic acid on PEPCK gene expression. Biochem J. 303, 737-742.
64. O'Brien, R. M., Noisin, E. L., Suwanichkul, A., Yamasaki, T. et al. 1995 HNF3 and hormone-regulated expression of the PEPCK and insulin-like growth factor-binding protein 1 genes. Molec. Cell. Biol. 15, 1747-1758.
65. Price, D. J., Grove, J. R., Calvo, V., Avruch, J. & Bierer, B. E. 1992 Rapamycin-induced inhibition of the 70kD S6 protein kinase. Science, Wash. 257, 973-977.
66. Price, L. S., Norman, J. C., Ridley, A. J. & Koffer, A. 1995 The small GTPases Rac and Rho as regulators of secretion in mast cells. Curr. Biol. 5, 68-73.
67. Rahn, T., Ridderstrale, M., Tornqvist, H., Manganiello, V., Fredrikson, G., Belfrage, P. & Degerman, E. 1994 Essential role of PI-3 kinase in insulin induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. FEBS Lett. 350, 314-318.
68. Ridley, A. J., Paterson, H. F., Johnson, C. L., Diekman, D. & Hall, A. 1992 The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
69. Shepherd, P. R., Nave, B. T. & Siddle, K. 1995 Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes. Biochem. J. 305, 25-28.
70. Shimizu, Y. & Shimazu, T. 1994 Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes. Biochem. Biophys. Res. Comm. 202, 660-665.
71. Shiran, R., Aronheim, A., Rosen, A., Park, C. W., Leshkowitz, D. & Walker, M. D. 1993 Positive and negative regulation of insulin gene transcription. Biochem. Soc. Trans. 21, 150-154.
72. Stokoe, D., Campbell, D. G., Nakielny, S., Hidaka, H., Leevers, S. J., Marshall, C. & Cohen, P. 1992 MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J. 11, 3985-3994.
73. Stumpo, D. J. & Blackshear, P. J. 1986 Insulin and growth factor effects on c-fos expresssion in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes. Proc. natn Acad. Sci. U.S.A. 83, 9453-9457.
74. Stumpo, D. J., Stewart, T. N., Gilman, M. Z. & Blackshear, P. J. 1988. Identification of c-fos sequences involved in induction by insulin and phorbol esters. J. biol. Chem. 263, 1611-1614.
75. Sturgill, T. W., Ray, L. B., Erikson, E. & Maller, J. L. 1988 Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature, Lond. 334, 715-718.
76. Sun, X. J., Crimmins, D., L., Myers, M. G. J., Miralpeix, M. & White, M. F. 1993 Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Molec. Cell. Biol. 13, 7418-7428.
77. Sun, X. J., Rothenberg, P., Kahn, R. C., Backer, J. M. et al. 1991 Structure of insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature, Lond. 352, 73-77.
78. Sutherland, C. & Cohen, P. 1994 The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro. FEBS Lett. 338, 37-12.
79. Sutherland, C., Leighton, I. A. & Cohen, P. 1993 Inactivation of glycogen synthase kinase-3β by phosphoryl-ation; new kinase connections in insulin and growth factor signalling. Biochem. J. 296, 15-19.
80. Sutherland, C., O'Brien, R. M. & Granner, D. K. 1995 Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of Phosphoenolpyruvate Carboxykinase gene expression by insulin. J. biol. Chem. 270, 15501-15506.
81. Takaishi, K., Kikuchi, A., Kuroda, S., Kotani, K., Sasaki, T. & Takai, Y. 1993 Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Molec. Cell. Biol. 13, 72-79.
82. Taub, R., Roy, A., Dieter, R. & Koontz, J. 1987 Insulin as a growth factor in rat hepatoma cells. J. biol. Chem. 262, 10893-10897.
83. Tobe, K., Kadowaki, T., Tamemoto, H., Ueki, K. et al. 1991 Insulin and 12-O-Tetradecanoylphorbol-13-acetate Activation of Two Immunologically Distinct Myelin Basic Protein/Microtubule-associated Protein 2 (MBP/MAP2) Kinases via de Noro phosphorylation of Threonine and Tyrosine Residues. J. biol. Chem. 266, 24793-24803.
84. Toker, A., Meyer, M., Reddy, K. K., Falck, J. R. et al. 1994 Activation of PKC family members by the novel polyphosphoinositides PI-3,4-P2 and PI-3,4,5-P3. J. biol. Chem. 269, 32358-32367.
85. Tominaga, T., Sugie, K., Hirata, M., Fukata, J., Uchida, A., Imura, H. & Marumiya, S. 1993 Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho. J. biol. Chem. 120, 1529-1537.
86. Traverse, S., Gomez, N., Paterson, H., Marshall, C. & Cohen, P. 1992 Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Biochem. J. 288, 351-355.
87. Vlahos, C. J., Matter, W. F., Hui, K. Y. & Brown, R. F. 1994 A specific inhibitor of PI 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. biol. Chem. 269, 5241-5248.
88. Welsh, G. I., Foulstone, E. J., Young, S. W., Tavare, J. M. & Proud, C. G. 1994 Wortmannin inhibits the effects of insulin and serum on the activities of GSK3 and MAPK. Biochem. J. 303, 15-20.
89. White, M. F. & Kahn, C. R. 1994 The insulin signalling system. J. biol. Chem. 269, 1-4.
90. Yamamoto-Honda, R., Tobe, K., Kaburagi, Y., Ueki, K. et al. 1995 Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. J. biol. Chem. 270, 2729-2734.
91. Yao, R. & Cooper, G. M. 1995 Requirement for PI 3-kinase in the prevention of apoptosis by NGF. Science, Wash. 267, 2003-2006.
92. Yeh, J.-I., Gulve, E. A., Rameh, L. & Birnbaum, M. J. 1995 The effects of wortmannin on rat skeletal muscle. J. biol. Chem. 270, 2107-2111.