SCOPUS 정보 검색 플랫폼

ChemBioChem

Volumn 3, Issue 2-3, 2002, Pages 124-134

Combinatorial biosynthesis of antibiotics: Challenges and opportunities

(1) Walsh, Christopher T a

a HARVARD MEDICAL SCHOOL (United States)

Author keywords

Antibiotics; Biosynthesis; Combinatorial chemistry

Indexed keywords

ACYL CARRIER PROTEIN; ACYL COENZYME A; ANTIBIOTIC AGENT; CHLOROEREMOMYCIN; CYTOCHROME P450; ENZYME; ERYTHROMYCIN; GLYCOPEPTIDE; GLYCOSYLTRANSFERASE; LACTAM DERIVATIVE; LACTONE DERIVATIVE; NATURAL PRODUCT; PIKORMYCIN SYNTHASE; PIKROMYCIN; POLYKETIDE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; DRUG DERIVATIVE;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; COMBINATORIAL CHEMISTRY; CRYSTAL STRUCTURE; CYCLIZATION; DRUG MANUFACTURE; DRUG STRUCTURE; ENVIRONMENTAL FACTOR; ENZYME SYNTHESIS; GENETIC ENGINEERING; GLYCOSYLATION; PLANT STRESS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; REVIEW; STARVATION; X RAY CRYSTALLOGRAPHY; BIOSYNTHESIS; DRUG DESIGN; HUMAN;

BACTERIA (MICROORGANISMS);

ANTI-BACTERIAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; ERYTHROMYCIN; HUMANS; VANCOMYCIN;

EID: 0036523418 PISSN: 14394227 EISSN: None Source Type: Journal
DOI: 10.1002/1439-7633(20020301)3:2/3<124::AID-CBIC124>3.0.CO;2-J Document Type: Review

Times cited : (155)

References (79)

1
- 0029802138
- H.S. Gold, R. C. Moellering, N. Engl. J. Med. 1996, 335, 1448-1453.
- (1996) N. Engl. J. Med. , vol.335 , pp. 1448-1453
- Gold, H.S.¹ Moellering, R.C.²

2
- 0032475992
- D. Cane, C. Walsh, C. Khosla, Science 1998, 282, 63-68.
- (1998) Science , vol.282 , pp. 63-68
- Cane, D.¹ Walsh, C.² Khosla, C.³

3
- 0000427346
- B. Shen, Top. Curr. Chem. 2000, 209, 1-51.
- (2000) Top. Curr. Chem. , vol.209 , pp. 1-51
- Shen, B.¹

4
- 0001436716
- L. Katz, Chem. Rev. 1997, 97, 2557-2576.
- (1997) Chem. Rev. , vol.97 , pp. 2557-2576
- Katz, L.¹

5
- 9444278428
- M. A. Marahiel, T. Stachelhaus, H. A. Mootz, Chem. Rev. 1997, 97, 2651-2674.
- (1997) Chem. Rev. , vol.97 , pp. 2651-2674
- Marahiel, M.A.¹ Stachelhaus, T.² Mootz, H.A.³

6
- 0001296027
- H. von Döhren, U. Keller, J. Vater, R. Zocher, Chem. Rev. 1997, 97, 2675-2705.
- (1997) Chem. Rev. , vol.97 , pp. 2675-2705
- Von Döhren, H.¹ Keller, U.² Vater, J.³ Zocher, R.⁴

7
- 0024585686
- R. Nagarajan, A. A. Schabel, J. L. Occolowitz, F. T. Counter, J. L. Ott, A. M. Felty-Duckworth, J. Antibiot. 1989, 42, 63-72.
- (1989) J. Antibiot. , vol.42 , pp. 63-72
- Nagarajan, R.¹ Schabel, A.A.² Occolowitz, J.L.³ Counter, F.T.⁴ Ott, J.L.⁵ Felty-Duckworth, A.M.⁶

8
- 0034694714
- R. Kerns, S. D. Dong, S. Fukuzaka, J. Carbeck, J. Kohler, L. Silver, D. Kahne, J. Am. Chem. Soc. 2000, 122, 12608-12609.
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 12608-12609
- Kerns, R.¹ Dong, S.D.² Fukuzaka, S.³ Carbeck, J.⁴ Kohler, J.⁵ Silver, L.⁶ Kahne, D.⁷

9
- 0026415106
- S. Donadio, M. J. Staver, J. B. McAlpine, S. J. Swanson, L. Katz, Science 1991, 252, 675-679.
- (1991) Science , vol.252 , pp. 675-679
- Donadio, S.¹ Staver, M.J.² McAlpine, J.B.³ Swanson, S.J.⁴ Katz, L.⁵

10
- 0025081416
- J. Cortes, S. F. Haydock, G. A. Roberts, D. J. Bevitt, P. F. Leadlay, Nature 1990, 348, 176-178.
- (1990) Nature , vol.348 , pp. 176-178
- Cortes, J.¹ Haydock, S.F.² Roberts, G.A.³ Bevitt, D.J.⁴ Leadlay, P.F.⁵

11
- 0001768006
- For a review, see: K. C. Nicolaou, C. N. C. Boddy, S. F. Brase, N. Winssinger, Angew. Chem. 1999, 111, 2230-2287; Angew. Chem. Int. Ed. 1999, 38, 2096-2152.
- (1999) Angew. Chem. , vol.111 , pp. 2230-2287
- Nicolaou, K.C.¹ Boddy, C.N.C.² Brase, S.F.³ Winssinger, N.⁴

12
- 0033516914
- For a review, see: K. C. Nicolaou, C. N. C. Boddy, S. F. Brase, N. Winssinger, Angew. Chem. 1999, 111, 2230-2287; Angew. Chem. Int. Ed. 1999, 38, 2096-2152.
- (1999) Angew. Chem. Int. Ed , vol.38 , pp. 2096-2152

13
- 0032033520
- A. M. Wageningen, P. N. Kirkpatrick, D. H. Williams, B. R. Harris, J. K. Kershaw, N. J. Lennard, M. Jones, S. J. M. Jones, P. J. Solenberg, Chem. Biol. 1998, 5, 155-162.
- (1998) Chem. Biol. , vol.5 , pp. 155-162
- Wageningen, A.M.¹ Kirkpatrick, P.N.² Williams, D.H.³ Harris, B.R.⁴ Kershaw, J.K.⁵ Lennard, N.J.⁶ Jones, M.⁷ Jones, S.J.M.⁸ Solenberg, P.J.⁹

14
- 0027932534
- C. M. Kao, L. Katz, C. Khosla, Science 1994, 265, 509-512.
- (1994) Science , vol.265 , pp. 509-512
- Kao, C.M.¹ Katz, L.² Khosla, C.³

15
- 0032738419
- Q. Xue, G. Ashley, C. R. Hutchinson, D. V. Santi, Proc. Natl. Acad. Sci. USA 1999, 96, 11740-11745.
- (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 11740-11745
- Xue, Q.¹ Ashley, G.² Hutchinson, C.R.³ Santi, D.V.⁴

16
- 0033515090
- R. McDaniel, A. Thamchaipenet, C. Gustaffson, H. Fu, M. C. Betlach, M. Betlach, G. Ashley, Proc. Natl. Acad. Sci. USA 1999, 96, 1846-1851.
- (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 1846-1851
- McDaniel, R.¹ Thamchaipenet, A.² Gustaffson, C.³ Fu, H.⁴ Betlach, M.C.⁵ Betlach, M.⁶ Ashley, G.⁷

17
- 0027998112
- H.-w. Liu, J. Thorson, Annu. Rev. Microbiol. 1994, 48, 223-256.
- (1994) Annu. Rev. Microbiol. , vol.48 , pp. 223-256
- Liu, H.-W.¹ Thorson, J.²

18
- 3843086796
- A. Trefzer, J. Salas, A. Bechtold, Nat. Prod. Rep. 1999, 16, 283-299.
- (1999) Nat. Prod. Rep. , vol.16 , pp. 283-299
- Trefzer, A.¹ Salas, J.² Bechtold, A.³

19
- 0034426059
- T. A. Cropp, D. J. Wilson, K. A. Reynolds, Nature Biotechnol. 2000, 18, 980-983.
- (2000) Nature Biotechnol. , vol.18 , pp. 980-983
- Cropp, T.A.¹ Wilson, D.J.² Reynolds, K.A.³

20
- 0024595910
- M. G. Anderson, D. Monypenny, R. W. Rickards, J. M. Rothchild, J. Chem. Soc. Chem. Commun. 1989, 311-313.
- (1989) J. Chem. Soc. Chem. Commun. , pp. 311-313
- Anderson, M.G.¹ Monypenny, D.² Rickards, R.W.³ Rothchild, J.M.⁴

21
- 0032498205
- A. F. Marsden, B. Wilkinson, J. Cortes, N. J. Dunster, J. Staunton, P. F. Leadlay, Science 1998, 279, 199-202.
- (1998) Science , vol.279 , pp. 199-202
- Marsden, A.F.¹ Wilkinson, B.² Cortes, J.³ Dunster, N.J.⁴ Staunton, J.⁵ Leadlay, P.F.⁶

22
- 0035918586
- S. J. Admiraal, C. Walsh, C. Khosla, Biochemistry 2001, 40, 6116-6123.
- (2001) Biochemistry , vol.40 , pp. 6116-6123
- Admiraal, S.J.¹ Walsh, C.² Khosla, C.³

23
- 0002973568
- (Eds.: C. R. Hutchinson, J. McAlpine), Society for Industrial Microbiology, Fairfax, VA
- H. A. McArthur in Developments in Industrial Microbiology - BMP'97 (Eds.: C. R. Hutchinson, J. McAlpine), Society for Industrial Microbiology, Fairfax, VA, 1998, pp. 43-48.
- (1998) Developments in Industrial Microbiology - BMP'97 , pp. 43-48
- McArthur, H.A.¹

24
- 0030875774
- J. R. Jacobson, C. R. Hutchinson, D. E. Cane, C. Khosla, Science 1997, 277, 367-369.
- (1997) Science , vol.277 , pp. 367-369
- Jacobson, J.R.¹ Hutchinson, C.R.² Cane, D.E.³ Khosla, C.⁴

25
- 0035793858
- B. A. Pfeifer, S. J. Admiraal, H. Gramajo, D. E. Cane, C. Khosla, Science 2001, 291, 1790-1792.
- (2001) Science , vol.291 , pp. 1790-1792
- Pfeifer, B.A.¹ Admiraal, S.J.² Gramajo, H.³ Cane, D.E.⁴ Khosla, C.⁵

26
- 0017802490
- G. M. Sheldrick, P. G. Jones, O. Kennard, D. H. Williams, G. A. Smith, Nature 1978, 271, 223-225.
- (1978) Nature , vol.271 , pp. 223-225
- Sheldrick, G.M.¹ Jones, P.G.² Kennard, O.³ Williams, D.H.⁴ Smith, G.A.⁵

27
- 0012091895
- R. Ciabatti, J. K. Kettering, G. Winters, G. Tuan, L. Zerilli, B. Cavalleri, J. Antibiot. 1989, 42, 236-241.
- (1989) J. Antibiot. , vol.42 , pp. 236-241
- Ciabatti, R.¹ Kettering, J.K.² Winters, G.³ Tuan, G.⁴ Zerilli, L.⁵ Cavalleri, B.⁶

28
- 0034523992
- B. K. Hubbard, M. G. Thomas, C. T. Walsh, Chem. Biol. 2000, 7, 931-942.
- (2000) Chem. Biol. , vol.7 , pp. 931-942
- Hubbard, B.K.¹ Thomas, M.G.² Walsh, C.T.³

29
- 0034616852
- O. W. Choroba, D. H. Williams, J. B. Spencer, J. Am. Chem. Soc. 2000, 122, 5389-5390.
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 5389-5390
- Choroba, O.W.¹ Williams, D.H.² Spencer, J.B.³

30
- 2642591970
- L. E. Khaw, G. A. Bohm, S. Metcalfe, J. Staunton, P. F. Leadlay, J. Bacteriol. 1998, 180, 809-814.
- (1998) J. Bacteriol. , vol.180 , pp. 809-814
- Khaw, L.E.¹ Bohm, G.A.² Metcalfe, S.³ Staunton, J.⁴ Leadlay, P.F.⁵

31
- 0034645602
- H. Yamase, L. Zhao, H.-w. Liu, J. Am. Chem. Soc. 2000, 122, 12397-12398.
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 12397-12398
- Yamase, H.¹ Zhao, L.² Liu, H.-W.³

32
- 0033610483
- L. Zhao, J. Ahlert, Y. Xue, J. Thorson, D. H. Sherman, H.-w. Liu, J. Am. Chem. Soc. 1999, 121, 9881-9882.
- (1999) J. Am. Chem. Soc. , vol.121 , pp. 9881-9882
- Zhao, L.¹ Ahlert, J.² Xue, Y.³ Thorson, J.⁴ Sherman, D.H.⁵ Liu, H.-W.⁶

33
- 0034974319
- L. R. Tang, R. McDaniel, Chem. Biol. 2001, 8, 547-555.
- (2001) Chem. Biol. , vol.8 , pp. 547-555
- Tang, L.R.¹ McDaniel, R.²

34
- 0034686686
- J. Jiang, J. B. Biggins, J. Thorson, J. Am. Chem. Soc. 2000, 122, 6803-6804.
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 6803-6804
- Jiang, J.¹ Biggins, J.B.² Thorson, J.³

35
- 4244059507
- C. Khosla, Chem. Rev. 1997, 97, 2577-2590.
- (1997) Chem. Rev. , vol.97 , pp. 2577-2590
- Khosla, C.¹

36
- 0031271543
- J. Staunton, B. Wilkinson, Chem. Rev. 1997, 97, 2611-2630.
- (1997) Chem. Rev. , vol.97 , pp. 2611-2630
- Staunton, J.¹ Wilkinson, B.²

37
- 0032710712
- L. Katz, R. McDaniel, Med. Res. Rev. 1999, 19, 543-558.
- (1999) Med. Res. Rev. , vol.19 , pp. 543-558
- Katz, L.¹ McDaniel, R.²

38
- 0033574774
- P. Belshaw, C. Walsh, T. Stachelhaus, Science 1999, 284, 486-489.
- (1999) Science , vol.284 , pp. 486-489
- Belshaw, P.¹ Walsh, C.² Stachelhaus, T.³

39
- 0030294470
- R. Lambalot, A. Gehring, R. Flugel, P. Zuber, M. Lacelle, M. A. Marahiel, R. Reed, C. Khosla, C. Walsh, Chem. Biol. 1996, 3, 923-936.
- (1996) Chem. Biol. , vol.3 , pp. 923-936
- Lambalot, R.¹ Gehring, A.² Flugel, R.³ Zuber, P.⁴ Lacelle, M.⁵ Marahiel, M.A.⁶ Reed, R.⁷ Khosla, C.⁸ Walsh, C.⁹

40
- 0033179468
- T. Stachelhaus, H. D. Mootz, M. A. Marahiel, Chem. Biol. 1999, 6, 493-505.
- (1999) Chem. Biol. , vol.6 , pp. 493-505
- Stachelhaus, T.¹ Mootz, H.D.² Marahiel, M.A.³

41
- 0034013269
- G. L. Challis, J. Ravel, C. A. Townsend, Chem. Biol. 2000, 7, 211-224.
- (2000) Chem. Biol. , vol.7 , pp. 211-224
- Challis, G.L.¹ Ravel, J.² Townsend, C.A.³

42
- 0030756031
- E. Conti, T. Stachelhaus, M. A. Marahiel, P. Brick, EMBO J. 1997, 16, 4174-4183.
- (1997) EMBO. J. , vol.16 , pp. 4174-4183
- Conti, E.¹ Stachelhaus, T.² Marahiel, M.A.³ Brick, P.⁴

43
- 0030763125
- X. Ruan, D. L. Stassi, A. Pereda, D. Zeidner, A. Shvakumar, S. Kakavas, M. Jackson, R. G. Summers, L. Katz, J. Bacteriol. 1997, 179, 6416-6425.
- (1997) J. Bacteriol. , vol.179 , pp. 6416-6425
- Ruan, X.¹ Stassi, D.L.² Pereda, A.³ Zeidner, D.⁴ Shvakumar, A.⁵ Kakavas, S.⁶ Jackson, M.⁷ Summers, R.G.⁸ Katz, L.⁹

44
- 0029034197
- T. Stachelhaus, A. Schneider, M. A. Marahiel, Science 1995, 269, 69-72.
- (1995) Science , vol.269 , pp. 69-72
- Stachelhaus, T.¹ Schneider, A.² Marahiel, M.A.³

45
- 0034705130
- H. D. Mootz, D. Schwarzer, M. A. Marahiel, Proc. Natl. Acad. Sci. USA 2000, 97, 5848-5853.
- (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 5848-5853
- Mootz, H.D.¹ Schwarzer, D.² Marahiel, M.A.³

46
- 0033485280
- D. E. Cane, C. Walsh, Chem. Biol. 1999, 6, R319-325.
- (1999) Chem. Biol. , vol.6
- Cane, D.E.¹ Walsh, C.²

47
- 0034796211
- L. Du, C. Sanchez, B. Shen, Metab. Eng. 2001, 3, 78-95.
- (2001) Metab. Eng. , vol.3 , pp. 78-95
- Du, L.¹ Sanchez, C.² Shen, B.³

48
- 0012039428
- T. Keating, D. E. Ehmann, R. M. Kohli, C. G. Marshall, J. W. Trauger, C. Walsh, ChemBioChem 2001, 2, 101-109.
- (2001) ChemBioChem. , vol.2 , pp. 101-109
- Keating, T.¹ Ehmann, D.E.² Kohli, R.M.³ Marshall, C.G.⁴ Trauger, J.W.⁵ Walsh, C.⁶

49
- 0034615668
- Y. Xue, D. Wilson, D. H. Sherman, Gene 2000, 245, 203-211.
- (2000) Gene , vol.245 , pp. 203-211
- Xue, Y.¹ Wilson, D.² Sherman, D.H.³

50
- 0034598743
- Y. Xue, D. H. Sherman, Nature 2000, 403, 571-574.
- (2000) Nature , vol.403 , pp. 571-574
- Xue, Y.¹ Sherman, D.H.²

51
- 0034141311
- B. Wilkinson, G. Foster, B. A. M. Rudd, N. L. Taylor, A. P. Blackaby, P. J. Sidebottom, D. J. Cooper, M. J. Dawson, A. D. Buss, S. Gaisser, I. U. Bohm, C. J. Rowe, J. Cortes, P. F. Leadlay, J. Staunton, Chem. Biol. 2000, 7, 111-117.
- (2000) Chem. Biol. , vol.7 , pp. 111-117
- Wilkinson, B.¹ Foster, G.² Rudd, B.A.M.³ Taylor, N.L.⁴ Blackaby, A.P.⁵ Sidebottom, P.J.⁶ Cooper, D.J.⁷ Dawson, M.J.⁸ Buss, A.D.⁹ Gaisser, S.¹⁰ Bohm, I.U.¹¹ Rowe, C.J.¹² Cortes, J.¹³ Leadlay, P.F.¹⁴ Staunton, J.¹⁵

52
- 0029027352
- J. Cortes, K. E. H. Weismann, G. A. Roberts, M. J. B. Brown, J. Staunton, P. F. Leadlay, Science 1995, 268, 1487-1489.
- (1995) Science , vol.268 , pp. 1487-1489
- Cortes, J.¹ Weismann, K.E.H.² Roberts, G.A.³ Brown, M.J.B.⁴ Staunton, J.⁵ Leadlay, P.F.⁶

53
- 0030723673
- C. Kao, M. McPherson, R. N. McDaniel, H. Fu, D. E. Cane, C. Khosla, J. Am. Chem. Soc. 1997, 119, 11339-11340.
- (1997) J. Am. Chem. Soc. , vol.119 , pp. 11339-11340
- Kao, C.¹ McPherson, M.² McDaniel, R.N.³ Fu, H.⁴ Cane, D.E.⁵ Khosla, C.⁶

54
- 0034648798
- J. W. Trauger, R. M. Kohli, H. D. Mootz, M. A. Marahiel, C. Walsh, Nature 2000, 407, 215-217.
- (2000) Nature , vol.407 , pp. 215-217
- Trauger, J.W.¹ Kohli, R.M.² Mootz, H.D.³ Marahiel, M.A.⁴ Walsh, C.⁵

55
- 0035912930
- J. W. Trauger, R. M. Kohli, C. Walsh, Biochemistry 2001, 40, 7092-7098.
- (2001) Biochemistry , vol.40 , pp. 7092-7098
- Trauger, J.W.¹ Kohli, R.M.² Walsh, C.³

56
- 0035912883
- R. M. Kohli, J. W. Trauger, D. Schwarzer, M. A. Marahiel, C. Walsh, Biochemistry 2001, 40, 7099-7108.
- (2001) Biochemistry , vol.40 , pp. 7099-7108
- Kohli, R.M.¹ Trauger, J.W.² Schwarzer, D.³ Marahiel, M.A.⁴ Walsh, C.⁵

57
- 0029794009
- M. Kurz, W. Gurba, Biochemistry 1996, 35, 12570-12575.
- (1996) Biochemistry , vol.35 , pp. 12570-12575
- Kurz, M.¹ Gurba, W.²

58
- 0000878162
- (Eds.: L. C. Vining, C. Stuttard), Butterworth-Heinemann, Newton, MA
- H. van Dohren in Genetics and Biochemistry of Antibiotic Production (Eds.: L. C. Vining, C. Stuttard), Butterworth-Heinemann, Newton, MA, 1995, pp. 129-171.
- (1995) Genetics and Biochemistry of Antibiotic Production , pp. 129-171
- Van Dohren, H.¹

59
- 0028284699
- G. Weber, K. Schorgendorfer, E. Schneider-Scherzer, E. Leitner, Curr. Genet. 1994, 26, 120-125.
- (1994) Curr. Genet. , vol.26 , pp. 120-125
- Weber, G.¹ Schorgendorfer, K.² Schneider-Scherzer, E.³ Leitner, E.⁴

60
- 0033835373
- L. Du, C. Sanchez, M. Chen, D. J. Edwards, B. Shen, Chem. Biol. 2000, 7, 623-642.
- (2000) Chem. Biol. , vol.7 , pp. 623-642
- Du, L.¹ Sanchez, C.² Chen, M.³ Edwards, D.J.⁴ Shen, B.⁵

61
- 0033168682
- L. Hendrickson, C. R. Davis, C. Roach, D. K. Nguyen, T. Aldrich, P. C. McAda, C. D. Reeves, Chem. Biol. 1999, 6, 429-439.
- (1999) Chem. Biol. , vol.6 , pp. 429-439
- Hendrickson, L.¹ Davis, C.R.² Roach, C.³ Nguyen, D.K.⁴ Aldrich, T.⁵ McAda, P.C.⁶ Reeves, C.D.⁷

62
- 0034673983
- T. Stachelhaus, C. Walsh, Biochemistry 2000, 39, 5775-5787.
- (2000) Biochemistry , vol.39 , pp. 5775-5787
- Stachelhaus, T.¹ Walsh, C.²

63
- 0025004152
- D. J. Smith, J. E. Alison, G. Turner, EMBO J. 1990, 9, 2743-2750.
- (1990) , vol.9 , pp. 2743-2750
- Smith, D.J.¹ Alison, J.E.² Turner, G.³ Embo, J.⁴

64
- 0033080078
- D. Konz, M. A. Marahiel, Chem. Biol. 1999, 6, R39-R48.
- (1999) Chem. Biol. , vol.6
- Konz, D.¹ Marahiel, M.A.²

65
- 0032829915
- T. Keating, C. Walsh, Curr. Opin. Chem. Biol. 1999, 3, 598-606.
- (1999) Curr. Opin. Chem. Biol. , vol.3 , pp. 598-606
- Keating, T.¹ Walsh, C.²

66
- 0025859219
- J. M. Weber, J. O. Leung, S. J. Swanson, K. B. Idler, J. B. McAlpine, Science 1991, 252, 114.
- (1991) Science , vol.252 , pp. 114
- Weber, J.M.¹ Leung, J.O.² Swanson, S.J.³ Idler, K.B.⁴ McAlpine, J.B.⁵

67
- 0026500150
- J. F. Anderson, C. R. Hutchinson, J. Bacteriol. 1992, 174, 725-735.
- (1992) J. Bacteriol. , vol.174 , pp. 725-735
- Anderson, J.F.¹ Hutchinson, C.R.²

68
- 0027455631
- D. L. Stassi, S. Donadio, M. J. Staver, L. Katz, J. Bacteriol. 1993, 175, 182-189.
- (1993) J. Bacteriol , vol.175 , pp. 182-189
- Stassi, D.L.¹ Donadio, S.² Staver, M.J.³ Katz, L.⁴

69
- 0032552963
- M. C. Betlach, J. T. Kealy, M. Betlach, G. W. Ashley, R. McDaniel, Biochemistry 1998, 37, 14937-14942.
- (1998) Biochemistry , vol.37 , pp. 14937-14942
- Betlach, M.C.¹ Kealy, J.T.² Betlach, M.³ Ashley, G.W.⁴ McDaniel, R.⁵

70
- 0034094917
- S. Shah, Q. Xue, L. Tang, J. R. Carney, M. Betlach, R. McDaniel, J. Antibiot. 2000, 53, 502-508.
- (2000) J. Antibiot. , vol.53 , pp. 502-508
- Shah, S.¹ Xue, Q.² Tang, L.³ Carney, J.R.⁴ Betlach, M.⁵ McDaniel, R.⁶

71
- 0012036620
- unpublished results
- B. Hubbard, C. Walsh, unpublished results.
- Hubbard, B.¹ Walsh, C.²

72
- 0035036477
- H.-w. Chen, C. Walsh, Chem. Biol. 2001, 8, 301-312.
- (2001) Chem. Biol. , vol.8 , pp. 301-312
- Chen, H.-W.¹ Walsh, C.²

73
- 0033763525
- D. Hoffmeister, K. Ichinose, S. Domann, B. Faust, A. Trefzer, G. Drager, A. Kirschning, C. Fischer, E. Kunzel, D. W. Bearden, J. Rohr, A. Bechtold, Chem. Biol. 2000, 7, 821-831.
- (2000) Chem. Biol. , vol.7 , pp. 821-831
- Hoffmeister, D.¹ Ichinose, K.² Domann, S.³ Faust, B.⁴ Trefzer, A.⁵ Drager, G.⁶ Kirschning, A.⁷ Fischer, C.⁸ Kunzel, E.⁹ Bearden, D.W.¹⁰ Rohr, J.¹¹ Bechtold, A.¹²

74
- 0033404581
- M. Doumith, R. Legrand, C. Lang, J. Salas, M. C. Raynal, Mol. Microbiol. 1999, 34, 1039-1048.
- (1999) Mol. Microbiol. , vol.34 , pp. 1039-1048
- Doumith, M.¹ Legrand, R.² Lang, C.³ Salas, J.⁴ Raynal, M.C.⁵

75
- 0034012110
- S. Gaisser, J. Reather, G. Wirtz, L. Kellenberger, J. Staunton, P. F. Leadlay, Mol. Microbiol. 2000, 36, 391-401.
- (2000) Mol. Microbiol. , vol.36 , pp. 391-401
- Gaisser, S.¹ Reather, J.² Wirtz, G.³ Kellenberger, L.⁴ Staunton, J.⁵ Leadlay, P.F.⁶

76
- 0031105304
- P. J. Solenberg, P. Matsushima, D. R. Stack, S. C. Wilkie, R. C. Thompson, R. H. Baltz, Chem. Biol. 1997, 4, 195-202.
- (1997) Chem. Biol. , vol.4 , pp. 195-202
- Solenberg, P.J.¹ Matsushima, P.² Stack, D.R.³ Wilkie, S.C.⁴ Thompson, R.C.⁵ Baltz, R.H.⁶

77
- 0035901490
- H. Losey, M. Peczuh, Z. Chen, U. S. Eggert, S. D. Dong, I. Pelczer, D. Kahne, C. Walsh, Biochemistry 2001, 40, 4745-4755.
- (2001) Biochemistry , vol.40 , pp. 4745-4755
- Losey, H.¹ Peczuh, M.² Chen, Z.³ Eggert, U.S.⁴ Dong, S.D.⁵ Pelczer, I.⁶ Kahne, D.⁷ Walsh, C.⁸

78
- 0033574768
- R. S. Gokhale, S. Y. Tsuji, D. E. Cane, C. Khosla, Science 1999, 284, 482-484.
- (1999) Science , vol.284 , pp. 482-484
- Gokhale, R.S.¹ Tsuji, S.Y.² Cane, D.E.³ Khosla, C.⁴

79
- 0035957047
- S. Y. Tsuji, D. E. Cane, C. Khosla, Biochemistry 2001, 40, 2326-2331.
- (2001) Biochemistry , vol.40 , pp. 2326-2331
- Tsuji, S.Y.¹ Cane, D.E.² Khosla, C.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.