Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin

Nature Biotechnology

Volumn 18, Issue 9, 2000, Pages 980-983

  Cropp, T A ^a   Wilson, D J ^a   Reynolds, K A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Avermectin; Biosynthesis; Polyketide; Streptomyces

Indexed keywords

ANSATRIENIN A; ANTIFUNGAL AGENT; AVERMECTIN; COENZYME A; CYCLOHEXYLCARBONYL COENZYME A; DORAMECTIN; FATTY ACID DERIVATIVE; POLYKETIDE; SHIKIMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME MECHANISM; FATTY ACID SYNTHESIS; FERMENTATION; GENE CASSETTE; GENE CLUSTER; GENE EXPRESSION; NONHUMAN; PLASMID; PRIORITY JOURNAL; REDUCTION; STREPTOCOCCUS; STREPTOMYCES LIVIDANS;

ANTHELMINTICS; BIOTECHNOLOGY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; COENZYME A; CYCLOHEXANECARBOXYLIC ACIDS; FATTY ACIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; IVERMECTIN; MODELS, CHEMICAL; MODELS, GENETIC; MULTIGENE FAMILY; PLASMIDS; SHIKIMIC ACID; STREPTOMYCES;

STREPTOCOCCUS; STREPTOMYCES; STREPTOMYCES AVERMITILIS; STREPTOMYCES COLLINUS; STREPTOMYCES LIVIDANS;

EID: 0034426059     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/79479     Document Type: Article

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