The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: Cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster

Chemistry and Biology

Volumn 7, Issue 11, 2000, Pages 821-831

  Hoffmeister, D ^a   Ichinose, K ^b   Domann, S ^a,c   Faust, B ^a   Trefzer, A ^a   Drager G ^c   Kirschning, A ^c   Fischer, C ^d   Kunzel E ^d   Bearden, D W ^e   Rohr, J ^d   Bechthold, A ^a,f  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF TOKYO   (Japan)

^c CLAUSTHAL UNIVERSITY OF TECHNOLOGY   (Germany)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e CENTER FOR COASTAL ENVIRONMENTAL HEALTH AND BIOMOLECULAR RESEARCH   (United States)

^f General Biology   (Germany)

Author keywords

D olivose; Deoxysugar biosynthesis; Glycosyltransferase; L rhodinose; Urdamycin

Indexed keywords

BIOCHEMICAL PATHWAY; BIOSYNTHESIS; DELETION MUTANT; DEOXYSUGAR; GENE INACTIVATION; GLYCOSYLTRANSFERASE; OLIVOSE; OPEN READING FRAME; RHODINOSE; STREPTOMYCES FRADIAE; URDAMYCIN;

ANTHRAQUINONES; ANTIBIOTICS, ANTINEOPLASTIC; CLONING, MOLECULAR; DEOXY SUGARS; GENE SILENCING; GENETIC COMPLEMENTATION TEST; GLYCOSYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIGENE FAMILY; MUTATION; PLASMIDS; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 0033763525     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00029-6     Document Type: Article

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