Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase

Chemistry and Biology

Volumn 7, Issue 2, 2000, Pages 111-117

  Wilkinson, Barrie ^a   Foster, Graham ^a   Rudd, Brian A M ^a   Taylor, Nicholas L ^a   Blackaby, Andrew P ^a   Sidebottom, Philip J ^a   Cooper, David J ^a   Dawson, Michael J ^a   Buss, Anthony D ^a   Gaisser, Sabine ^b   Böhm, Ines U ^b   Rowe, Christine J ^b   Cortés, Jesús ^a,b   Leadlay, Peter F ^b   Staunton, James ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Erythromycin; Iterative; Modular; Polyketide synthase; Saccharopolyspora erythraea

Indexed keywords

DELETION MUTANT; DRUG SYNTHESIS; ENZYME ACTIVITY; ERYTHROMYCIN; FERMENTATION MEDIUM; FUNGAL MUTANT; MACROLIDE; POLYKETIDE SYNTHASE; SACCAROPOLYSPORA ERYTHRAEA; WILD RELATIVE;

BACTERIA (MICROORGANISMS); SACCHAROPOLYSPORA ERYTHRAEA;

EID: 0034141311     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00076-4     Document Type: Article

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