Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics

Chemistry and Biology

Volumn 7, Issue 12, 2000, Pages 931-942

  Hubbard, B K ^a   Thomas, M G ^a   Walsh, C T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Antibiotic; Hydroxyphenylglycine; Hydroxyphenylpyruvate; Tyrosine; Va ncomycin

Indexed keywords

BIOCHEMICAL PATHWAY; CHLOROEREMOMYCIN; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE CLUSTER; GENE SEQUENCING; GLYCOSYLATION; HEPTAPEPTIDE; MICROBIAL ACTIVITY; MOLECULAR CONFORMATION; OPEN READING FRAME; OXFENICINE; POLYPEPTIDE ANTIBIOTIC AGENT;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCINE; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; OPEN READING FRAMES; SUBSTRATE SPECIFICITY; TRANSAMINASES; VANCOMYCIN;

AMYCOLATOPSIS; PROKARYOTA;

EID: 0034523992     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00043-0     Document Type: Article

References (21)

1. Harnessing the biosynthetic code: Combinations, permutations and mutations
2. Modular peptide synthetases involved in non-ribosomal peptide synthesis
3. How do peptide synthetases generate structural diversity?
4. Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine
5. The glycopeptide story-how to kill the deadly 'superbugs'
6. Biosynthetic studies on antibiotic A47934
7. Structure of complestatin, a very strong inhibitor of protease activity of complement in the human complement system
8. Complestatin, a potent anti-complement substance produced by Streptomyces lavendulae. I. Fermentation, isolation and biological characterization
9. Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation
10. CDA: Calcium-dependent antibiotics from Streptomyces coelicolor A3 containing unusual residues
11. On the biosynthesis of the antibiotic vancomycin
12. The biosynthesis of ristocetin
13. Biosynthetic studies of aridicin antibiotics.I. Labeling patterns and overall pathways
14. Vancomycin and other glycopeptides
15. Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic
16. Dioxygen activation by enzymes in mononuclear non-heme iron active sites
17. Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: An enzyme involved in the tyrosine degradation pathway
18. Biosynthesis of the vancomycin group of antibiotics: Involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine
19. (S)-Mandelate dehydrogenase from Pseudomonas putida: Mechanistic studies with alternate substrates and pH and kinetic isotope effects
20. 14C-amino acids into nocardicin A by growing cells
21. Alternate substrates and inhibitors of bacterial 4-hydroxyphenylpyruvate dioxygenase