Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin

Biochemistry

Volumn 37, Issue 42, 1998, Pages 14937-14942

  Betlach, Melanie C ^a   Kealey, James T ^a   Betlach, Mary C ^a   Ashley, Gary W ^a   McDaniel, Robert ^a  

^a KOSAN BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DNA; ERYTHROMYCIN; KETOLIDE; MACROLIDE; NARBOMYCIN; OXYGENASE; PIKROMYCIN; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; ENZYME SPECIFICITY; GENE; GENE CLUSTER; HYDROXYLATION; NONHUMAN; OXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES VENEZUELAE;

AMINO ACID SEQUENCE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYSIS; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; GENES, BACTERIAL; HISTIDINE; HYDROXYLATION; KINETICS; MACROLIDES; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; STREPTOMYCES;

ESCHERICHIA COLI; FELIS CATUS; STREPTOMYCES; STREPTOMYCES VENEZUELAE;

EID: 0032552963     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981699c     Document Type: Article

References (29)

1. Weber, J. M., Leung, J. O., Swanson, S. J., Idler, K. B., and McAlpine, J. B. (1991) Science 252, 114-117.
2. Stassi, D., Donadio, S., Staver, M. J., and Katz, L. (1993) J. Bacteriol. 175, 182-189.
3. Haydock, S. F., Dowson, J. A., Dhillon, N., Roberts, G. A., Cortes, J., and Leadlay, P. F. (1991) Mol. Gen. Genet. 230, 120-128.
4. Merson-Davies, L. A., and Cundliffe, E. (1994) Mol. Microbiol. 13, 349-355.
5. Inouye, M., Takada, Y., Muto, N., Beppu, T., and Horinouchi, S. (1994) Mol. Gen. Genet. 245, 456-464.
6. Rodriguez, A. M., Olano, C., Mendez, C., and Hutchinson, C. R. (1995) FEMS Microbiol. Lett. 127, 117-120.
7. Cane, D. E., and Graziani, E. I. (1998) J. Am. Chem. Soc. 120, 2682-2683.
8. Lambalot, R. H., Cane, D. E., Aparicio, J. J., and Katz, L. (1995) Biochemistry 34, 1858-1866.
9. Andersen, J. P., Tatsuta, K., Gunji, H., Ishiyama, T., and Hutchinson, C. R. (1993) Biochemistry 32, 1905-1913.
10. Carreras, C. W., and Santi, D. V. (1998) Curr. Opin. Biotechnol. 9, 403-411.
11. Hutchinson, C. R. (1998) Curr. Opin. Microbiol. 1, 319-329.
12. Donadio, S., Staver, M. J., McAlpine, J. B., Swanson, S. J., and Katz, L. (1991) Science 252, 675-679.
13. Donadio, S., McAlpine, J. B., Sheldon, P. J., Jackson, M., and Katz, L. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 7119-7123.
14. Ruan, X. R., Pereda, A., Stassi, D. L., Zeidner, D., Summers, R. G., Jackson, M., Shivakumar, A., Kakavas, S., Staver, M. J., Donadio, S., and Katz, L. (1997) J. Bacteriol. 179, 6416-6425.
15. Liu, L., Thamchaipenet, A., Fu, H., Betlach, M., and Ashley, G. (1997) J. Am. Chem. Soc. 119, 10553-10554.
16. Jacobsen, J. R., Hutchinson, C. R., Cane, D. E., and Khosla, C. (1997) Science 277, 367-369.
17. Marsden, A. F. A., Wilkinson, B., Cortes, J., Dunster, N. J., Staunton, J., and Leadlay, P. F. (1998) Science 279, 199-202.
18. Griesgraber, G., Or, Y. T., Chu, D. T. W., Nilius, A. M., Johnson, P. M., Flamm, R. K., Henry, R. F., and Plattner, J. J. (1996) J. Antibiot. 49, 465-477.
19. Hopwood, D. A., Bibb, M. J., Chater, K. F., Kieser, T., Bruton, C. J., Kieser, H. M., Lydiate, D. J., Smith, C. P., Ward, J. M., and Schrempf, H. (1985) Genetic manipulation of streptomyces: A laboratory manual. The John Innes Foundation, Norwich, U.K.
20. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
21. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
22. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410.
23. Bibb, M. J., Findlay, P. R., and Johnson, M. W. (1984) Gene 30, 157-166.
24. Cupp-Vickery, J. R., Han, O., Hutchinson, C. R., and Poulos, T. L. (1996) Nat. Struct. Biol. 3, 632-637.
25. Cupp-Vickery, J. R., and Poulos, T. L. (1997) Steroids 62, 112-116.
26. Andersen, J. F., and Hutchinson, C. R. (1992) J. Bacteriol. 174, 725-735.
27. Ednie, L. M., Spangler, S. K., Jacobs, M. R., and Appelbaum, P. C. (1997) Antimicrob. Agents Chemother. 41, 1033-1036.
28. Jamjian, C., Biedanbach. D. J., and Jones, R. N. (1997) Antimicrob. Agents Chemother. 41, 454-459.
29. Arisawa, A., Tsunekawa, H., Okamura, K., and Okamoto, R. (1995) Biosci. Biotechnol. Biochem. 59, 582-588.