Constitutive activation of toll-mediated antifungal defense in serpin- deficient Drosophila

Science

Volumn 285, Issue 5435, 1999, Pages 1917-1919

  Levashina, Elena A ^a,c   Langley, Emma ^a,d   Green, Clare ^b   Gubb, David ^b   Ashburner, Michael ^b   Hoffmann, Jules A ^a   Reichhart, Jean Marc ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d WELLCOME CRC INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PEPTIDE; SERINE PROTEINASE INHIBITOR;

ANTIFUNGAL ACTIVITY; ARTICLE; DROSOPHILA; EMBRYO PATTERN FORMATION; GENE ACTIVATION; GENE CASSETTE; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE MUTATION; GENE OVEREXPRESSION; HOST RESISTANCE; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIFUNGAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BODY PATTERNING; DROSOPHILA; DROSOPHILA PROTEINS; ESCHERICHIA COLI; GENES, INSECT; HEMOLYMPH; INSECT PROTEINS; MEMBRANE GLYCOPROTEINS; MICROCOCCUS LUTEUS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PEPTIDES; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; SERINE PROTEINASE INHIBITORS; SERPINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; UP-REGULATION;

CACTACEAE;

EID: 0033578917     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5435.1917     Document Type: Article

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31. We are grateful to R. DeLotto for providing antisera to Spaetzle, and to J. Roote and J. A. Campos-Ortega for fly stocks. The technical assistance of A. Meunier and R. Klock is gratefully acknowledged. Supported by institutional funds from the CNRS and grants from the Human Frontiers Science Program and Rhone-Poulenc Agro. J.-M. R. acknowledges support from the Marie Curie Research Training Program and the NATO Scientific Research Program. Work in M.A.'s laboratory was supported by a Medical Research Council Programme grant. The authors from both laboratories thank the Fondation Les Treilles (Schlumberger), which sponsored a meeting at Les Treilles where this collaboration was initiated.