Different Toll-like receptor agonists induce distinct macrophage responses

Journal of Leukocyte Biology

Volumn 69, Issue 6, 2001, Pages 1036-1044

  Jones, B W ^a   Means, T K ^a   Heldwein, K A ^a   Keen, M A ^a   Hill, P J ^a   Belisle, J T ^a   Fenton, M J ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Innate immunity; Signal transduction; Tuberculosis

Indexed keywords

GLYCOLIPID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; BACTERIUM CULTURE; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; MACROPHAGE; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUBERCULOSIS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DROSOPHILA PROTEINS; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MICE; MYCOBACTERIUM TUBERCULOSIS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOLS; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034976848     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (60)

1. The biology of Toll-like receptors
2. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
3. Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
4. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
5. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
6. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
7. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
8. A family of human receptors structurally related to Drosophila Toll
9. TLR6: A novel member of an expanding Toll-like receptor family
10. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9
11. Three novel mammalian Toll-like receptors: Gene structure, expression, and evolution
12. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the tlr4 gene
13. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
14. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
15. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
16. Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
17. TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
18. Differential effects of a Toll-Like receptor antagonist on macrophage responses to M. tuberculosis
19. Interleukin-1/Toll receptor family members: Receptor structure and signal transduction pathways
20. Lipopolysaccharide induces physical proximity between CD14 and Toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-κB
21. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
22. The interleukin-1 receptor/Toll-like receptor superfamily: Signal generators for pro-inflammatory interleukins and microbial products
23. Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes
24. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
25. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages
26. Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes
27. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated RAW 264.7 cells: Differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production
28. A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages
29. Lipopolysaccharide induces Jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidyl-choline-dependent phospholipase C
30. Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-α, signal transduction
31. Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2
32. Lipoarabinomannan: Multiglycosylated form of the mycobacterial mannosylphosphatidylinositols
33. Biosynthesis of mannophosphoinositides by Mycobacterium phlei. The family of dimannophosphoinositides
34. Lipoprotein antigens of Mycobacterium tuberculosis
35. Simultaneous electroelution of whole SDS-polyacrylamide gels for the direct cellular analysis of complex protein mixtures
36. 15N]nitrate in biological fluids
37. Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II
38. Rapid detection of octamer binding proteins with 'mini-extracts,' prepared from a small number of cells
39. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes
40. Human Toll-like receptors mediate cellular activation by M. tuberculosis
41. Structural definition of acylated phosphatidylinositol mannosides from Mycobacterium tuberculosis: Definition of a common anchor for lipomannan and lipoarabinomannan
42. Relative contribution of transcription and translation to the induction of tumor necrosis factor-alpha by lipopolysaccharide
43. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
44. Toll-like receptors: A growing family of immune receptors that are differentially expressed and regulated by different leukocytes
45. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
46. Human Toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
47. Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids
48. Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex
49. Signaling by Toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages
50. A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-κB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways
51. The human Toll signaling pathway: Divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
52. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
53. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
54. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants
55. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
56. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
57. Activation of the RON receptor tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: Phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression
58. Intracellular trafficking in Mycobacterium tuberculosis- and Mycobacterium avium-infected macrophages
59. Integration of mycobacterial lipoarabinomannans into glycosylphosphatidylinositol-rich domains of lymphomonocytic cell plasma membranes
60. Expression of Toll-like receptor 2 on γδ T cells bearing invariant Vγ6/Vδ1 induced by Escherichia coli infection in mice