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Volumn 48, Issue 3, 1999, Pages 395-401

Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population

Author keywords

Black population; CYP2C19; CYP2D6; Genotype

Indexed keywords

CYCLOGUANIL; CYTOCHROME P450; CYTOCHROME P450 2C19; DEBRISOQUINE 4 HYDROXYLASE; LIPID; MEPHENYTOIN; PROGUANIL; SPARTEINE; UNCLASSIFIED DRUG;

EID: 0032868321     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00019.x     Document Type: Article
Times cited : (54)

References (38)
  • 3
    • 0028007553 scopus 로고
    • CYP2D6 genotype determination in the Danish population
    • Brøsen K, Nielsen PN, Brusgaard K, et al. CYP2D6 genotype determination in the Danish population. Eur J Clin Pharmacol 1994; 47: 221-225.
    • (1994) Eur J Clin Pharmacol , vol.47 , pp. 221-225
    • Brøsen, K.1    Nielsen, P.N.2    Brusgaard, K.3
  • 4
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Lundqvist E, Bertilsson L, et al. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Pro Natl Acad Sci 1993; 90: 11825-11829.
    • (1993) Pro Natl Acad Sci , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3
  • 5
    • 0024319297 scopus 로고
    • Mephenytoin and sparteine oxidation: Genetic polymorphisms in Denmark
    • Drøhse A, Bathum L, Brøsen K, Gram LF. Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark. Br J Clin Pharmacol 1989; 27: 620-625.
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 620-625
    • Drøhse, A.1    Bathum, L.2    Brøsen, K.3    Gram, L.F.4
  • 6
    • 0029064096 scopus 로고
    • Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
    • Dahl M, Johansson I, Bertilsson L, et al. Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther 1995; 274: 516-520.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 516-520
    • Dahl, M.1    Johansson, I.2    Bertilsson, L.3
  • 7
    • 0031960328 scopus 로고    scopus 로고
    • Ultrarapid metabolism of sparteine: Frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by RFLP and long PCR
    • Bathum L, Johansson I, Ingelman-Sundberg M, et al. Ultrarapid metabolism of sparteine: frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by RFLP and long PCR. Pharmacogenetics 1998; 8: 119-123.
    • (1998) Pharmacogenetics , vol.8 , pp. 119-123
    • Bathum, L.1    Johansson, I.2    Ingelman-Sundberg, M.3
  • 8
    • 0028942981 scopus 로고
    • Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population
    • Agúndez JAG, Ledesma MC, Ladero JM, Benítez J. Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population. Clin Pharmacol Ther 1995; 57: 265-269.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 265-269
    • Agúndez, J.A.G.1    Ledesma, M.C.2    Ladero, J.M.3    Benítez, J.4
  • 9
    • 0022178173 scopus 로고
    • Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations
    • Nakamura K, Goto F, Ray WA, McAllister CB, et al. Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther 1985; 38: 402-408.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 402-408
    • Nakamura, K.1    Goto, F.2    Ray, W.A.3    McAllister, C.B.4
  • 10
    • 0019140947 scopus 로고
    • A study of the debrisoquine hydroxylation polymorphism in a Nigerian population
    • Mbanefo C, Bababunmi EA, Mahgoub A. A study of the debrisoquine hydroxylation polymorphism in a Nigerian population. Xenobiotica 1980; 10: 811-818.
    • (1980) Xenobiotica , vol.10 , pp. 811-818
    • Mbanefo, C.1    Bababunmi, E.A.2    Mahgoub, A.3
  • 11
    • 0026849692 scopus 로고
    • Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians
    • Lennard MS, Iyun AO, Jackson PR, et al. Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians. Pharmacogenetics 1992; 2: 89-92.
    • (1992) Pharmacogenetics , vol.2 , pp. 89-92
    • Lennard, M.S.1    Iyun, A.O.2    Jackson, P.R.3
  • 12
    • 0021846817 scopus 로고
    • Dissociation of coregulatory control of debrisoquine/penformin and sparteine oxidation in Ghanians
    • Woolhouse NM, Eichelbaum M, Oatcs NS. Dissociation of coregulatory control of debrisoquine/penformin and sparteine oxidation in Ghanians. Clin Pharmacol Ther 1985, 37: 512-521.
    • (1985) Clin Pharmacol Ther , vol.37 , pp. 512-521
    • Woolhouse, N.M.1    Eichelbaum, M.2    Oatcs, N.S.3
  • 13
    • 0026506140 scopus 로고
    • Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquine and S-mephenytoin
    • Bertilsson L, Lou YQ, Du YL. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquine and S-mephenytoin. Clin Pharmacol Ther 1992; 51: 388-397.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 388-397
    • Bertilsson, L.1    Lou, Y.Q.2    Du, Y.L.3
  • 14
    • 0026031652 scopus 로고
    • Interethnic variation of drug metabolism
    • Kalow W. Interethnic variation of drug metabolism. Trends Pharmacol Sci 1991; 12: 102-107.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 102-107
    • Kalow, W.1
  • 15
    • 0027965620 scopus 로고
    • Genetic analysis of the Chinese Cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
    • Johansson I, Oscarson M, Yue Q, et al. Genetic analysis of the Chinese Cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 1994; 46: 452-459.
    • (1994) Mol Pharmacol , vol.46 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.3
  • 16
    • 0025572192 scopus 로고
    • Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
    • Alvan G, Bechtel P, Iselius L, Gundert-Remy U. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur J Clin Pharmacol 1990; 39: 533-537.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 533-537
    • Alvan, G.1    Bechtel, P.2    Iselius, L.3    Gundert-Remy, U.4
  • 17
    • 0022220338 scopus 로고
    • Genetic polymorphism of mephenytoin, p. (4′) -hydroxylation: Difference between Orientals and Caucasians
    • Jurima M, Inaba T, Kadar D, Kalow W. Genetic polymorphism of mephenytoin, p. (4′) -hydroxylation: difference between Orientals and Caucasians. Br J Clin Pharmacol 1985; 19: 483-487.
    • (1985) Br J Clin Pharmacol , vol.19 , pp. 483-487
    • Jurima, M.1    Inaba, T.2    Kadar, D.3    Kalow, W.4
  • 18
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • de Morais SMF, Wilkinson GR, Blaisdell J, et al. The major genetic defect responsible for the polymorphism of S-Mephenytoin metabolism in humans. J Biol Chemistry 1994; 269: 15419-15422.
    • (1994) J Biol Chemistry , vol.269 , pp. 15419-15422
    • De Morais, S.M.F.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 19
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
    • de Morais SMF, Wilkinson GR, Blaisdell J, et al. Identification of a new genetic defect responsible for the polymorphism of (S)-Mephenytoin metabolism in Japanese. Mol Pharmacol 1994; 46: 594-598.
    • (1994) Mol Pharmacol , vol.46 , pp. 594-598
    • De Morais, S.M.F.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 20
    • 0029055448 scopus 로고
    • Phenotyping and genotyping of S-mephenytoin hydroxylase (cyrochrome P450 2C19) in a Shona population of Zimbabwe
    • Masimirembwa C, Bertilsson L, Johansson I, et al. Phenotyping and genotyping of S-mephenytoin hydroxylase (cyrochrome P450 2C19) in a Shona population of Zimbabwe. Clin Pharmacol Ther 1995: 57: 656-661.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 656-661
    • Masimirembwa, C.1    Bertilsson, L.2    Johansson, I.3
  • 21
    • 0028865992 scopus 로고
    • A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype
    • Brøsen K, de Morais SMF, Meyer UA, Goldstein JA. A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype. Pharmacogenetics 1995; 5: 312-317.
    • (1995) Pharmacogenetics , vol.5 , pp. 312-317
    • Brøsen, K.1    De Morais, S.M.F.2    Meyer, U.A.3    Goldstein, J.A.4
  • 22
    • 0029960882 scopus 로고    scopus 로고
    • Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S mephenytoin oxidation in Tanzanians
    • Skjelbo E, Mutabingwa TK, Bygbjerg I, et al. Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S mephenytoin oxidation in Tanzanians. Clin Pharmacol Ther 1996: 59: 304-311.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 304-311
    • Skjelbo, E.1    Mutabingwa, T.K.2    Bygbjerg, I.3
  • 24
    • 0024336503 scopus 로고
    • S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquine
    • Sanz EJ, Villén T, Alm C, Bertilsson L. S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquine. Clin Pharmacol Ther 1989; 45: 495-499.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 495-499
    • Sanz, E.J.1    Villén, T.2    Alm, C.3    Bertilsson, L.4
  • 25
    • 0025080352 scopus 로고
    • Genotyping of poor metabolizers of debrisoqume by allele-specific PCR amplification
    • Heim M, Meyer UA. Genotyping of poor metabolizers of debrisoqume by allele-specific PCR amplification. Lancet 1990; 336: 529-532.
    • (1990) Lancet , vol.336 , pp. 529-532
    • Heim, M.1    Meyer, U.A.2
  • 26
    • 0007293059 scopus 로고    scopus 로고
    • Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of allels with duplication of the CYP2D6 gene
    • Løvlic R, Daly AK, Molven A, et al. Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of allels with duplication of the CYP2D6 gene. FEBS 1996; 392: 30-34.
    • (1996) FEBS , vol.392 , pp. 30-34
    • Løvlic, R.1    Daly, A.K.2    Molven, A.3
  • 27
    • 0031936795 scopus 로고    scopus 로고
    • A dual label oligonucleotide ligation assay for detection of the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles involving time resolved fluorometry
    • Bathum L, Hansen TS, Hørder M, Brøsen M. A dual label oligonucleotide ligation assay for detection of the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles involving time resolved fluorometry. Ther Drug Monit 1998; 20: 1-6.
    • (1998) Ther Drug Monit , vol.20 , pp. 1-6
    • Bathum, L.1    Hansen, T.S.2    Hørder, M.3    Brøsen, M.4
  • 28
    • 0028969436 scopus 로고
    • Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms - A population study
    • Madsen H, Kramer Nielsen K, Brøsen K. Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms - a population study. Br J Clin Pharmacol 1995; 39: 433-439.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 433-439
    • Madsen, H.1    Kramer Nielsen, K.2    Brøsen, K.3
  • 29
    • 0025950370 scopus 로고
    • Debrisoquine/Sparteine hydroxylation genotype and phenotype: Analysis of common mutations and alleles of CYP2D6 in a European population
    • Broly F, Gaedig A, Heim M, et at. Debrisoquine/Sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population. DNA Cell Biology 1991; 10: 545-558.
    • (1991) DNA Cell Biology , vol.10 , pp. 545-558
    • Broly, F.1    Gaedig, A.2    Heim, M.3
  • 31
    • 0029853664 scopus 로고    scopus 로고
    • A novel mutant variant of the CYP2D6 gene (CYP2D617) common in a black African population: Association with diminished debrisoquine hydroxylase activity
    • Masimirembwa C, Persson I, Bertilsson L, et al. A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity. Br J Clin Pharmacol 1996; 42: 713-719.
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 713-719
    • Masimirembwa, C.1    Persson, I.2    Bertilsson, L.3
  • 32
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu E, Persson I, Bertilsson L, et al. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 1996; 278: 441-446.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 441-446
    • Aklillu, E.1    Persson, I.2    Bertilsson, L.3
  • 33
    • 0025305464 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism-clinical aspects
    • Eichelbaum M, Gross AS. The genetic polymorphism of debrisoquine/sparteine metabolism-clinical aspects. Pharmac Ther 1990; 46: 377-394.
    • (1990) Pharmac Ther , vol.46 , pp. 377-394
    • Eichelbaum, M.1    Gross, A.S.2
  • 34
    • 0026004805 scopus 로고
    • Lower prevalence of the debrisoquine oxidative poor metaboliser phenotype in American blacks versus white subjects
    • Rolling MW, Cherrie J, Schell MJ, et al. Lower prevalence of the debrisoquine oxidative poor metaboliser phenotype in American blacks versus white subjects. Clin Pharmacol Ther 1991; 50: 308-313.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 308-313
    • Rolling, M.W.1    Cherrie, J.2    Schell, M.J.3
  • 35
    • 0030462277 scopus 로고    scopus 로고
    • S mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians
    • Persson I, Aklillu E, Rodrigues F, et al. S mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians. Pharmacogenetics 1996; 6: 521-526.
    • (1996) Pharmacogenetics , vol.6 , pp. 521-526
    • Persson, I.1    Aklillu, E.2    Rodrigues, F.3
  • 36
    • 0025970955 scopus 로고
    • Limitation to the use of the urinary S-/R-mephenytoin ratio in pharmacogenctic studies
    • Zang Y, Blouin RA, McNamara PJ, et al. Limitation to the use of the urinary S-/R-mephenytoin ratio in pharmacogenctic studies. Br J Clin Pharmacol 1993; 31: 350-352.
    • (1993) Br J Clin Pharmacol , vol.31 , pp. 350-352
    • Zang, Y.1    Blouin, R.A.2    McNamara, P.J.3
  • 37
    • 0029587180 scopus 로고
    • Use of Omeprazole as a probe drag for CYP2C19 phenotype in Swedish Caucasians - Comparison with s-mephenytoin hydroxylation phenotype and CYP2C19 genotype
    • Chang M, Dahl M, Tybring G, et al. Use of Omeprazole as a probe drag for CYP2C19 phenotype in Swedish Caucasians - comparison with s-mephenytoin hydroxylation phenotype and CYP2C19 genotype. Pharmacogenetics 1995; 5: 358-363.
    • (1995) Pharmacogenetics , vol.5 , pp. 358-363
    • Chang, M.1    Dahl, M.2    Tybring, G.3


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