Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 3, 1996, Pages 444-448

  Odani, Atsuko ^a   Hashimoto, Yukiya ^a   Takayanagi, Kazunobu ^a   Otsuki, Yuko ^a   Koue, Toshiko ^a   Takano, Mikihisa ^a   Yasuhara, Masato ^a,b   Hattori, Haruo ^a   Furusho, Kenshi ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Michaelis Menten elimination; nonlinear mixed effects model (NONMEM); phenytoin; population pharmacokinetics; zonisamide

Indexed keywords

CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID; ZONISAMIDE;

ADULT; ARTICLE; CHILD; COMPARTMENT MODEL; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG MONITORING; EPILEPSY; HUMAN; MAJOR CLINICAL STUDY; MICHAELIS CONSTANT;

EID: 13244300645     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.444     Document Type: Article

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