Hepatic cytochrome P450 CYP2C activity in psoriasis: Studies using proguanil as a probe compound

Acta Dermato-Venereologica

Volumn 78, Issue 2, 1998, Pages 81-83

  Helsby, Nuala A ^a   Ward, Stephen A ^a   Parslew, Richard A G ^a   Friedmann, Peter S ^a   Rhodes, Lesley E ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Disease severity; Metaboliser status; Retinol

Indexed keywords

CYCLOGUANIL; CYTOCHROME P450 ISOENZYME; LIVER ENZYME; PROGUANIL; RETINOL;

ADULT; ARTICLE; CLINICAL TRIAL; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; HUMAN; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PSORIASIS;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; ANTIMALARIALS; ARYL HYDROCARBON HYDROXYLASES; CHLOROGUANIDE; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; LIVER; MALE; MICROSOMES, LIVER; MIDDLE AGED; MIXED FUNCTION OXYGENASES; PHENOTYPE; PROSPECTIVE STUDIES; PSORIASIS; SEVERITY OF ILLNESS INDEX; TRIAZINES; VITAMIN A;

EID: 0031955095     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.1080/000155598433359     Document Type: Article

References (18)

1. Farber E, Nall ML. Genetics of psoriasis: a twin study. In: Farber, Cox, eds. Psoriasis. Stanford University Press; 1971. p. 7-13.
2. Vahlquist A, Törmä H. Retinoids and keratinisation: Current concepts. Int J Dermatol 1988; 27: 81-95.
3. Kragballe K, Jansen CT, Geiger J-M, Bjerke JR, Falk ES, Gip L, et al. A double-blind comparison of acitretin and etretinate in the treatment of severe psoriasis. Results of a Nordic multicentre study. Acta Derm Venereol (Stockh) 1989; 69: 35-40.
4. Posch KC, Enright WJ, Napoli JL. Retinoic acid synthesis by cytosol from the alcohol dehydrogenase negative deermouse. Arch Biochem Biophys 1989; 274: 171-178.
5. Napoli JL, Race KR. The biosynthesis of retinoic acid from retinol by rat tissues in vitro. Arch Biochem Biophys 1987; 255: 95-101.
6. Leo MA, Lieber CS. New pathway for retinoid metabolism in liver microsomes. J Biol Chem 1985; 260: 5228-5231.
7. Roberts ES, Vaz ADN, Coon MJ. Role of isozymes of rabbit microsomal cytochrome P450 in the metabolism of retinoic acid, retinol and retinal. Mol Pharmac 1992; 41: 427-433.
8. Leo MA, Lasker JM, Raucy JL, Kim C, Black M, Lieber CS. Metabolism of retinol and retinoic acid by human liver cytochrome P45011C8. Arch Biochem Biophys 1989; 269: 305-312.
9. Armstrong VL. Metabolism of chlorguanide, a unique mixed function oxidase substrate. Diss Abstr 1973; 33: 3832B.
10. Birkett DJ, Rees D, Andersson T, Gonzalez FJ, Miners JO, Veronese ME. In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase. Br J Clin Pharmac 1994; 37: 413-420.
11. Ward SA, Helsby NA, Skjelbo E, Brosen K, Gram LF, Breckenridge AM. The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism: a panel study. Br J Clin Pharmacol 1991; 31: 6892-6921.
12. Helsby NA, Ward SA, Howells RE, Breckenridge AM. In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450MP) enzyme. Br J Clin Pharmacol 1990; 30: 287-291.
13. Nanson S, Kuylen K, Björkman AB. Hair loss and scaling with proguanil. Lancet 1989; ii: 225.
14. Leo MA, Lieber CS. Hypervitaminosis A: a liver lovers lament. Hepatology 1988; 8: 412-417.
15. Vestey JP, Savin JA. Psoriasis worsened by antimalarial prophylaxis. J Infect 1992; 24: 211-212.
16. Helsby NA, Ward SA, Edwards IG, Howells RE, Breckenridge AM. The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism. Br J Clin Pharmacol 1990; 30: 593-598.
17. Zachariae H, Søgaard H. Liver biopsy in psoriasis. Dermatologica 1973; 146: 149-155.
18. Martini R, Jiang XM, Murray M. Pretranslational down-regulation of P450 2C11 in vitamin A deficient male rat liver: prevention by dietary retinoic acid supplementation. Fifth North American ISSX Meeting, Tucson, Arizona, U.S.A. October 17-21, 1993.